Kimiko MURAKAMI

Profile Information

Affiliation: Professor, Ochanomizu University
: (Concurrent)Professor, Faculty of Science, Division of Biology

Degree: -(The University of Tokyo)

Other name(s) (e.g. nickname): MUROFUSHI Kimiko
J-GLOBAL ID: 200901026414071446
researchmap Member ID: 1000361021

Research Interests

Research Areas

Research History

1996 - Present

Ochanomizu University
2004 - 2005

Ochanomizu University
2002 - 2004

Faculty of Science, Ochanomizu University
2001

、2005 ルイ・パスツール大学客員教授
1993 - 1996

Ochanomizu University
1993 - 1996

Lecturer of Ochanomizu University
1983 - 1993

Ochanomizu University
1983 - 1993

Assistant Professor of Ochanomizu University
1980 - 1983

Teikyo University
1980 - 1983

Assistant Professor of Teikyo University
1977 - 1980

ニューヨーク市公衆衛生研究所・研究員
1977 - 1980

Public Research Institute of The City of
1976 - 1977

Tsurumi University
1976 - 1977

Assistant Professor of Tsurumi University
New York Research Associate

Education

- 1976

The University of Tokyo
- 1976

Graduate School, Division of Medical Sciences, The University of Tokyo

Committee Memberships

2008 - Present

東京大学大学院総合文化研究科・教養学部運営諮問会議委員
2007 - Present

東京都立小石川中等学校運営委員会委員
2007 - Present

（独）科学技術振興機構 Science Window 編集委員会委員
2007 - Present

文部科学省科学技術・学術審議会研究計画・評価分科会委員
2007 - Present

文部科学省科学技術・学術審議会人材委員会委員
2007 - Present

文部科学省科学技術・学術審議会委員
2007 - Present

文部科学省独立行政法人評価委員会委員
2006 - Present

経済産業省独立行政法人評価委員会委員
2006 - Present

国立科学博物館日本の科学者・技術者展規格委員会委員
2005 - Present

林野庁森林セラピーステアリングコミッティ委員
2005 - Present

第20期日本学術会議連携会員
2005 - Present

内閣府男女共同参画会議基本問題専門調査会委員
2005 - Present

経済産業省日本工業標準調査会総会委員
2004 - Present

（独）科学技術振興機構国際科学技術コンテスト支援事業推進委員会副委員長（2007－委員長）
2004 - 2009

東京都自然科学教育に関する教育推進会議委員（副座長）
2003 - 2008

（公）山村冨美記念女性自然科学者研究助成基金運営委員
2003 - 2008

（公）林女性自然科学者研究助成基金運営委員
1998 - 2008

（社）大学婦人協会科学研究省令委員会委員
2005 - 2007

文部科学省科学技術・学術審議会審査部会委員（WG座長）
2003 - 2007

内閣府食品安全委員会専門委員

Misc.

128

Pertuzumab, a novel HER dimerization inhibitor, inhibits the growth of human lung cancer cells mediated by the HER3 signaling pathway

Kazuko Sakai, Hideyuki Yokote, Kimiko Murakami-Murofushi, Tomohide Tamura, Nagahiro Saijo, Kazuto Nishio

CANCER SCIENCE, 98(9) 1498-1503, Sep, 2007
Identification of Residues Responsible for Ligand Recognition and Regioisomeric Selectivity of Lysophosphatidic Acid Receptors Expressed in Mammalian Cells.

Fujiwara,Y, Sardar,V, Tokumura,A, Baker,D, Murakami-Murofushi,K, Parril,A, tTgyi,G

J. Biol. Chem., 1771 103-112, 2007
STAT3 and PKC Differentially Regulate Telomerase Activity during Megakaryocytic Differentiation of K562 Cells.

Nakadake,M, Sasaki,N, Kakiuchi,Y, Murakami-Murofushi,K, Yamada,O

Cell Cycle, 6(12) Epub ahead of print, 2007
Inhibition of transcellular tumor cell migration and metastasis by novel carba-derivatives of cyclic phosphatidic acid

Ayako Uchiyama, Mutsuko Mukai, Yuko Fujiwara, Susumu Kobayashi, Nobuyuki Kawai, Hiromu Murofushi, Masahiro Inoue, Shigenori Enoki, Yuichiro Tanaka, Tamotsu Niki …

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1771(1) 103-112, Jan, 2007
Cyclic phosphatidic acid is produced by autotaxin in blood

Satomi Tsuda, Shinichi Okudaira, Keiko Moriya-Ito, Chie Shimamoto, Masayuki Tanaka, Junken Aoki, Hiroyuki Arai, Kimiko Murakami-Murofushi, Tetsuyuki Kobayashi

JOURNAL OF BIOLOGICAL CHEMISTRY, 281(36) 26081-26088, Sep, 2006
Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis

Daniel L. Baker, Yuko Fujiwara, Kathryn R. Pigg, Ryoko Tsukahara, Susumu Kobayashi, Hiromu Murofushi, Ayako Uchiyama, Kimiko Murakami-Murofushi, Eunjin Koh, Russell W. Bandle …

JOURNAL OF BIOLOGICAL CHEMISTRY, 281(32) 22786-22793, Aug, 2006
In-frame deletion in the EGF receptor alters kinase inhibition by gefitinib

Kazuko Sakai, Hideyuki Yokote, Kimiko Murakami-Murofushi, Tomohide Tamura, Nagahiro Saijo, Kazuto Nishio

BIOCHEMICAL JOURNAL, 397(3) 537-543, Aug, 2006
Cyclic phosphatidic acid stimulates respiration without producing vasopressor or tachycardiac effects in rats

Harumi Hotta, Fusako Kagitani, Kimiko Murakami-Murofushi

EUROPEAN JOURNAL OF PHARMACOLOGY, 543(1-3) 27-31, Aug, 2006
Dimerization and the signal transduction pathway of a small in-frame deletion in the epidermal growth factor receptor

Kazuko Sakai, Tokuzo Arao, Tatsu Shimoyama, Kimiko Murofushi, Masaru Sekijima, Naoko Kaji, Tomohide Tamura, Nagahiro Saijo, Kazuto Nishio

FASEB JOURNAL, 20(2) 311-313, Feb, 2006
Regulation of levels of actin threonine phosphorylation during life cycle of Physarum polycephalum

Y Shirai, N Sasaki, Y Kishi, A Izumi, K Itoh, M Sameshima, T Kobayashi, K Murakami-Murofushi

CELL MOTILITY AND THE CYTOSKELETON, 63(2) 77-87, Feb, 2006
Identification of Residues Responsible for Ligand Recognition and Regioisomeric Selectivity of LPA Receptors Expressed in Mammalian Cells.

Fujiwara,Y, Sardar,V, Tokumura,A, Baker,D, Murakami-Murofushi,K, Parrill,A, Tigyi,G

J. Biol. Chem., 280(41) 35038-35050, 2005
A novel pyrazolone, 4,4-dichloro-1-(2,4-dichlorophenyl)-3-methyl-5-pyrazolone, as a potent catalytic inhibitor of human telomerase

Y Kakiuchi, N Sasaki, M Satoh-Masuoka, H Murofushi, K Murakami-Murofushi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 320(4) 1351-1358, Aug, 2004
Attenuation by cyclic phosphatidic acid of peritoneal metastasis of azoxymethane-induced intestinal cancers in Wistar rats

R Ishihara, M Tatsuta, H Iishi, M Baba, N Uedo, K Higashino, M Mukai, S Ishiguro, S Kobayashi, K Murakami-Murofushi

INTERNATIONAL JOURNAL OF CANCER, 110(2) 188-193, Jun, 2004
Transient posttranslational up-regulation of telomerase activity during megakaryocytic differentiation of K562 cells

M Nakatake, N Sasaki, K Murakami-Murofushi, O Yamada

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 314(4) 1080-1085, Feb, 2004
Physarolisin.

Murakami-Murofushi,K, Nishii,W, Takahashi,K

Handbook of Proteolytic Enzymes, 2nd Edition 1891-1893, 2004
Glom is a novel mitochondrial DNA packaging protein in Physarum polycephalum and causes intense chromatin condensation without suppressing DNA functions

N Sasaki, H Kuroiwa, C Nishitani, H Takano, T Higashiyama, T Kobayashi, Y Shirai, A Sakai, S Kawano, K Murakami-Murofushi …

MOLECULAR BIOLOGY OF THE CELL, 14(12) 4758-4769, Dec, 2003
Cyclic phosphatidic acid elicits neurotrophin-like actions in embryonic hippocampal neurons

Y Fujiwara, A Sebok, S Meakin, T Kobayashi, K Murakami-Murofushi, G Tigyi

JOURNAL OF NEUROCHEMISTRY, 87(5) 1272-1283, Dec, 2003
Cholesteryl glucoside-induced protection against gastric ulcer

S Kunimoto, W Murofushi, Yamatsu, I, Y Hasegawa, N Sasaki, S Kobayashi, T Kobayashi, H Murofushi, K Murakami-Murofushi

CELL STRUCTURE AND FUNCTION, 28(3) 179-186, Jun, 2003
Cyclic phosphatidic acid inhibits RhoA-mediated autophosphorylation of FAK at Tyr-397 and subsequent tumor-cell invasion

M Mukai, T Iwasaki, M Tatsuta, A Togawa, H Nakamura, K Murakami-Murofushi, S Kobayashi, F Imamura, M Inoue

INTERNATIONAL JOURNAL OF ONCOLOGY, 22(6) 1247-1256, Jun, 2003
Structural and Enzymatic Characterization of Physarolisin (formerly Physaropepsin) Proves that It is A Unique Serine-carboxyl Proteinase.

Nishii,W, Ueki,T, Miyashita,R, Kojima,M, Kim,Y.-T, Sasaki,N, Murakami-Murofushi,K, Takahashi,K

Biochem. Biophｙs. Res. Commun., 301(4) 1023-1029, 2003

Books and Other Publications

人類遺伝学用語事典（監修）

オーム社, 2008
検証『共通1次・センター試験』―その「教育」への影響をさぐる― （共著）

大学教育出版, 2008
ストレスの科学と健康（共著）

共立出版, 2008
プッチーとお友だち

冨山房インターナショナル, 2007
生物はみなきょうだい

冨山房インターナショナル, 2007
バイオサイエンス」

オーム社, 2007
女性と少子化（共著）

明石書店, 2006
こぐま園のプッチー

冨山房インターナショナル, 2006
今なぜ若者の理科離れか：科学者と社会の対話に向けて（共著）

科学技術協力財団, 2005
ストレスの生物学

オーム社, 2005
Brock微生物学（監訳）

オーム社, 2003
バイオサイエンス事典（共著）

朝倉書店, 2002
ライフサイエンス入門（共著）

オーム社, 2002
Bioactions and Synthesis of a Novel Lipid Mediator, Cyclic Phosphatidic Acid

World Rev. Nutr. Diet., 2001
Bioactions and Synthesis of a Novel Lipid Mediator, Cyclic Phosphatidic Acid

World Rev. Nutr. Diet., 2001
Characterization of Endogenous and Heterologously Expressed LPA receptor Subtypes.(共著)

Lysophospholipids and Eicosanoids in Cancer and in Cardiovascular and Neurodegenerative Diseases, 2000
A Novel Lipid Mediator, Cyclic Phosphatidic Acid(cPA), and Its Biological Functions.(共著)

Lysophospholipids and Eicosanoids in Cancer and in Cardiovascular and Neurodegenerative Diseases, 2000
やさしい細胞の科学（共著）

オーム社, 1999
Cell Sciences

1999
生化学辞典（分担執筆）

東京化学同人, 1998

Profile Information

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Misc.

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