MISC

2007年8月

A (18)F-FDG-positive, (67)Ga-negative, and transferrin receptor expression-negative patient with diffuse large B-cell lymphoma

ANNALS OF NUCLEAR MEDICINE
  • Tetsuya Tsujikawa
  • ,
  • Hidehiko Okazawa
  • ,
  • Tatsuro Tsuchida
  • ,
  • Yoshiki Demura
  • ,
  • Yoshiaki Imamura
  • ,
  • Yasuhisa Fujibayashi

21
6
開始ページ
375
終了ページ
378
記述言語
英語
掲載種別
DOI
10.1007/s12149-007-0037-8
出版者・発行元
SPRINGER

We recently experienced a case with uveitis suffering from fever of unknown origin suspected of being caused by sarcoidosis. Chest computed tomography showed right supraclavicular, bilateral mediastinal, and right hilar lymphadenopathy, and intensive abnormal uptake of 2-[(18)F]fluoro-2-deoxy-D-glucose ((18)F-FDG) was observed on positron emission tomography with (18)F-FDG (FDG-PET). On the other hand, (67)Ga scintigraphy showed almost no abnormal findings. Histopathological examination revealed the lesion to be a diffuse large B-cell lymphoma (DLBCL), namely, an aggressive non-Hodgkin lymphoma from a right supraclavicular lymph node biopsy specimen. Additional immunohistochemical analysis showed the negative expression of transferrin receptor (TfR) on the formalin-fixed paraffin-embedded specimen. Although DLBCL is generally considered to be a (67)Ga-avid tumor, it does not always have a large number of TFRs and that leads to a discrepancy between the (67)Ga scintigraphy and FDG-PET findings. FDG-PET should be more appropriate for the initial staging of DLBCL than (67)Ga scintigraphy, whereas (67)Ga scintigraphy might be able to provide additional information including prognostic factors and to support strategies that target TfR for cancer therapy.

リンク情報
DOI
https://doi.org/10.1007/s12149-007-0037-8
CiNii Articles
http://ci.nii.ac.jp/naid/10019863196
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/17705020
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000249217700011&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s12149-007-0037-8
  • ISSN : 0914-7187
  • CiNii Articles ID : 10019863196
  • PubMed ID : 17705020
  • Web of Science ID : WOS:000249217700011

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