論文

査読有り
2015年12月

Fatal reactivation of hepatitis B virus infection in a patient with adult T-cell leukemia-lymphoma receiving the anti-CC chemokine receptor 4 antibody mogamulizumab

HEPATOLOGY RESEARCH
  • Hideki Ifuku
  • ,
  • Shigeru Kusumoto
  • ,
  • Yasuhito Tanaka
  • ,
  • Haruhito Totani
  • ,
  • Takashi Ishida
  • ,
  • Masaya Okada
  • ,
  • Shuko Murakami
  • ,
  • Masashi Mizokami
  • ,
  • Ryuzo Ueda
  • ,
  • Shinsuke Iida

45
13
開始ページ
1363
終了ページ
1367
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/hepr.12513
出版者・発行元
WILEY

We report an adult T-cell leukemia-lymphoma (ATL) patient suffering from fatal reactivation of hepatitis B virus (HBV) infection after treatment with the anti-CC chemokine receptor 4 (CCR4) monoclonal antibody, mogamulizumab. HBV reactivation occurred without liver damage in this hepatitis B surface antigen (HBsAg) negative patient, who was seropositive for antibodies against the viral core and surface antigens at baseline, after two cycles of CHOP regimen (cyclophosphamide, doxorubicin, vincristine and prednisolone) followed by six cycles of THP-COP regimen (cyclophosphamide, pirarubicin, vincristine and prednisolone). Unexpectedly, mogamulizumab monotherapy for relapsed CCR4 positive ATL induced sudden and fatal liver failure due to HBV reactivation, despite antiviral prophylaxis with entecavir. This clinical course may not only offer important suggestions to prevent critical HBV reactivation in HBsAg positive cancer patients who receive immune-enhancing drugs such as anti-CCR4 antibody, but also provide a clue to understanding the pathogenesis of HBV reactivation following systemic chemotherapy.

リンク情報
DOI
https://doi.org/10.1111/hepr.12513
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25753008
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000368274900014&DestApp=WOS_CPL
URL
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84955187433&origin=inward
ID情報
  • DOI : 10.1111/hepr.12513
  • ISSN : 1386-6346
  • eISSN : 1872-034X
  • PubMed ID : 25753008
  • SCOPUS ID : 84955187433
  • Web of Science ID : WOS:000368274900014

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