2006年7月
Anti-inflammatory effect of spironolactone on human peripheral blood mononuclear cells
JOURNAL OF PHARMACOLOGICAL SCIENCES
- 巻
- 101
- 号
- 3
- 開始ページ
- 256
- 終了ページ
- 259
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1254/jphs.SC0060049
- 出版者・発行元
- JAPANESE PHARMACOLOGICAL SOC
We evaluated the effect of alacepril, CV-11974, and spironolactone on the production of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) in cultured human peripheral blood mononuclear cells stimulated with angiotensin (Ang) II. Alacepril, CV-11974, and spironolactone significantly reduced the enhanced production of MCP-1 and TNF-alpha induced by exogenous Ang II. Specifically, 10 mu M of spironolactone significantly reduced cytokine production, compared to the same dose of alacepril or CV-11974. These findings indicate that spironolactone may contribute to ameliorate the prognosis of patients with cardiovascular diseases by reducing Ang II-induced inflammation, although further exploration including determining the mechanisms would be required.
- リンク情報
- ID情報
-
- DOI : 10.1254/jphs.SC0060049
- ISSN : 1347-8613
- Web of Science ID : WOS:000239333700011