2018年12月
A severe combined immunodeficiency disease mouse model of human adenocarcinoma with lepidic-predominant growth.
Pathology, research and practice
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- 巻
- 214
- 号
- 12
- 開始ページ
- 2000
- 終了ページ
- 2003
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.prp.2018.09.021
Severe combined immunodeficiency disease (SCID) mice with human lepidic adenocarcinoma were established by the intrabronchial implantation of fresh surgically resected specimens. Human pulmonary adenocarcinoma tissue from 16 different cases was transplanted into SCID mice, and SCID mouse tumors were established from four of these cases (25%). Among the four tumors, the tumor cells of two SCID mice showed replacement lepidic growth of mouse alveolar structures accompanied by multiple intrapulmonary lesions. Human lung carcinoma cell lines showing lepidic growth are rare and the xenograft models using the SCID mouse model developed in the current study will be useful for analyzing the growth and/or progression patterns and clinical behavior of lepidic adenocarcinoma, the major histological subtype of human carcinoma of the lung.
- リンク情報
- ID情報
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- DOI : 10.1016/j.prp.2018.09.021
- PubMed ID : 30287185