盧群偉 (Qun-Wei LU) - マイポータル

基本情報

所属: 九州大学大学院医学系学府臨床薬理学日本学術振興会外国人特別研究員

学位: PhD

J-GLOBAL ID: 200901006551531887
researchmap会員ID: 1000363854

研究キーワード

研究分野

ライフサイエンス / 薬理学 /

MISC

Therapeutic effect of beta-adrenoceptor blockers using a mouse model of dilated cardiomyopathy with a troponin mutation

Dong-Yun Zhan, Sachio Morimoto, Cheng-Kun Du, Yuan-Yuan Wang, Qun-Wei Lu, Atsushi Tanaka, Tomomi Ide, Yoshikazu Miwa, Fumi Takahashi-Yanaga, Toshiyuki Sasaguri

CARDIOVASCULAR RESEARCH 84(1) 64-71 2009年10月
Targeted disruption of the cardiac troponin T gene causes sarcomere disassembly and defects in heartbeat within the early mouse embryo

Kiyomasa Nishii, Sachio Morimoto, Reiko Minakami, Yumi Miyano, Kanako Hashizume, Mika Ohta, Dong-Yun Zhan, Qun-Wei Lu, Yosaburo Shibata

DEVELOPMENTAL BIOLOGY 322(1) 65-73 2008年10月
Knock-in mouse model of dilated cardiomyopathy caused by troponin mutation

Cheng-Kun Du, Sachio Morimoto, Kiyomasa Nishii, Reiko Minakami, Mika Ohta, Naoto Tadano, Qun-Wei Lu, Yuan-Yuan Wang, Dong-Yun Zhan, Misato Mochizuki …

CIRCULATION RESEARCH 101(2) 185-194 2007年7月
Drastic Ca2+ sensitization of myofilament associated with a small structural change in troponin I in inherited restrictive cardiomyopathy

F Yumoto, QW Lu, S Morimoto, H Tanaka, N Kono, K Nagata, T Qjima, F Takahashi-Yanaga, Y Miwa, T Sasaguri …

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 338(3) 1519-1526 2005年12月
Cardiac troponin T mutation R141W found in dilated cardiomyopathy stabilizes the troponin T - tropomyosin interaction and causes a Ca2+-desensitization

Journal of Molecular & Cellular Cardiology 35(12):1421-1427 2003年
Cardiac troponin T mutation R141W found in dilated cardiomyopathy stabilizes the troponin T - tropomyosin interaction and causes a Ca2+-desensitization

Journal of Molecular & Cellular Cardiology 35(12):1421-1427 2003年
Ca2+-desensitizing effect of a deletion mutation ⊿K210 in cardiac troponin T that causes familial dilated cardiomyopathy

Proceedings of the National Academy of Sciences of the United States of America 99(2):913-918 2002年
Ca2+-desensitizing effect of a deletion mutation ⊿K210 in cardiac troponin T that causes familial dilated cardiomyopathy

Proceedings of the National Academy of Sciences of the United States of America 99(2):913-918 2002年
Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy

Journal of Molecular & Cellular Cardiology 33(12):2095-2107 2001年
Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy

Journal of Molecular & Cellular Cardiology 33(12):2095-2107 2001年

所属学協会

日本薬理学会

共同研究・競争的資金等の研究課題

トロポニン分子突然変異による遺伝性心筋症の病態発現機構の解明

2005年 - 2007年
Molecular pathogenic mechanism of inherited cardiomyopathies caused by mutations in cardiac troponin

2005年 - 2007年