Hasegawa Naoki - My portal

Profile Information

Affiliation: Professor, School of Medicine Department of Infectious Diseases, Keio University

Degree: モルモットエンドトキシン急性肺損傷における血漿ミエロペルオキシダーゼ測定の意義(Mar, 1992, KEIO University)

Researcher number: 20198724
J-GLOBAL ID: 200901084417702587
researchmap Member ID: 1000364202

Research Interests

Research Areas

Research History

2008 - Present

副センター長, 感染制御センター, 慶應義塾大学病院
Oct, 2014 - Apr, 2019

教授, Associate Professor Center for infectious Disease and Infection Control, 慶應義塾大学医学部
Apr, 2010 - Aug, 2014

准教授, Associate Professor Center for infectious Disease and Infection Control, 慶應義塾大学医学部
Apr, 2002 - 2008

室長補佐, 感染対策室, 慶應義塾大学病院
May, 2000 - Mar, 2002

専任講師, 呼吸器内科, 慶應義塾大学医学部
Apr, 1997 - Apr, 2000

研究検査科長(兼任), 国立療養所南横浜病院
Oct, 1994 - Mar, 1997

内科医長, 国立療養所南横浜病院
May, 1989 - Sep, 1994

専修医, 呼吸器内科, 慶應義塾大学医学部
Apr, 1987 - Apr, 1989

内科医員, 横浜市立市民病院
Apr, 1985 - Mar, 1987

研修医, 慶應義塾大学医学部内科

Education

Mar, 1985 - Mar, 1985

医学部, 慶應義塾大学

Papers

208

ADAM17 protects against elastase-induced emphysema by suppressing CD62L+ leukocyte infiltration in mice.

Shoji Suzuki, Makoto Ishii, Takanori Asakura, Ho Namkoong, Satoshi Okamori, Kazuma Yagi, Hirofumi Kamata, Tatsuya Kusumoto, Shizuko Kagawa, Ahmed E Hegab …

American journal of physiology. Lung cellular and molecular physiology, 318(6) L1172-L1182-L1182, Jun 1, 2020
Disseminated Mycobacterium massiliense infection in a patient with myelodysplastic syndrome undergoing allogeneic bone marrow transplantation

Toyama T, Mori T, Kato J, Sugita K, Hasegawa N, Nakata N, Hoshino Y, Okamoto S

Transplant Infectious Disease, 22(3) e13278, Jun 1, 2020 Peer-reviewed
Seasonal changes in indoor airborne fungal concentration in a hematology ward

Mori T, Kikuchi T, Kato J, Koda Y, Sakurai M, Kikumi O, Inose R, Murata M, Hasegawa N, Nakayama H …

Journal of Infection and Chemotherapy, 26(4) 363-366, Apr, 2020
Effect of refrigeration of blood samples in lithium-heparin tubes on QuantiFERON TB Gold Plus test result

Uwamino Y, Sakai A, Nishimura T, Noguchi M, Uno S, Fujiwara H, Mori M, Wakui M, Murata M, Hasegawa N

Journal of Infection and Chemotherapy, 26(3) 312-314, Mar, 2020
Showering is associated with Mycobacterium avium complex lung disease: An observational study in Japanese women

Uwamino Y, Nishimura T, Sato Y, Tamizu E, Uno S, Mori M, Fujiwara H, Kawabe H, Murata M, Hasegawa N

Journal of Infection and Chemotherapy, 26(3) 211-214, Mar, 2020
A nationwide questionnaire survey of clinic doctors on antimicrobial stewardship in Japan

Gu Y, Fujitomo Y, Soeda H, Nakahama C, Hasegawa N, Maesaki S, Maeda M, Matsumoto T, Miyairi I, Ohmagari N

Journal of Infection and Chemotherapy, 26(2) 149-156, Feb, 2020
IL-6 and G-CSF production resulting from lung cancer in an HIV patient

Kawakami N, Namkoong H, Masaki K, Kurebayashi Y, Shimoda M, Kotani H, Fujiwara H, Hasegawa N

IDCases, 19 e00693, 2020
Hidden disseminated extracutaneous AIDS-related Kaposi sarcoma

Kawakami N, Namkoong H, Shimoda M, Kotani H, Fujiwara H, Hasegawa N

IDCases, 19 e00716, 2020
The annual risk of tuberculosis infection in newly hired researchers and healthcare workers using interferon-gamma release assay in Japan

Nishimura T, Ota M, Mori M, Takano Y, Fujiwara H, Uwamino Y, Uno S, Hasegawa N

Journal of Infection and Chemotherapy, 2020 Peer-reviewed
Low serum estradiol levels are related to Mycobacterium avium complex lung disease: A cross-sectional study

Uwamino Y, Nishimura T, Sato Y, Tamizu E, Asakura T, Uno S, Mori M, Fujiwara H, Ishii M, Kawabe H …

BMC Infectious Diseases, 19(1) 1055, Dec 16, 2019 Peer-reviewed
Moxifloxacin resistance and genotyping of Mycobacterium avium and Mycobacterium intracellulare isolates in Japan

Yamaba Y, Ito Y, Suzuki K, Kikuchi T, Ogawa K, Fujiuchi S, Hasegawa N, Kurashima A, Higuchi T, Uchiya K.i …

Journal of Infection and Chemotherapy, 25(12) 995-1000, Dec, 2019
Methicillin-resistant Staphylococcus aureus carriers are vulnerable to bloodstream infection after living donor liver transplantation

Takemura Y, Hibi T, Shinoda M, Obara H, Minagawa T, Kitago M, Yagi H, Abe Y, Matsubara K, Oshima G …

Clinical Transplantation, 33(12) e13753, Dec 1, 2019
Nosocomial infection by human bocavirus and human rhinovirus among paediatric patients with respiratory risks

Kobayashi H, Shinjoh M, Sudo K, Kato S, Morozumi M, Koinuma G, Takahashi T, Takano Y, Tamura Y, Hasegawa N

Journal of Hospital Infection, 103(3) 341-348, Nov, 2019
Recovery of FRI-5 carbapenemase at a Japanese hospital where FRI-4 carbapenemase was discovered

Uwamino Y, Kubota H, Sasaki T, Kosaka A, Furuhashi M, Uno S, Kudoh J, Murata M, Hasegawa N

Journal of Antimicrobial Chemotherapy, 74(11) 3390-3392, Nov 1, 2019
Actual practice of standard treatment for pulmonary nontuberculous mycobacteriosis in Japan

Morimoto K, Izumi K, Ato M, Hasegawa N, Mitarai S

Respiratory Medicine, 158 67-69, Oct, 2019
Evaluation for optimal dosing of vancomycin in patients with different physical types

Hashimoto M, Iketani O, Ichinose N, Enoki Y, Taguchi K, Uno S, Uwamino Y, Hasegawa N, Matsumoto K

Journal of Infection and Chemotherapy, 25(9) 735-737, Sep, 2019
Impact of immunoglobulin G2 subclass level on late-onset bacterial infection after allogeneic hematopoietic stem cell transplantation

Yamazaki R, Kato J, Koda Y, Sakurai M, Tozawa K, Okayama M, Nakayama H, Watanuki S, Kikuchi T, Hasegawa N …

Transplant Infectious Disease, 21(3) e13086, Jun, 2019 Peer-reviewed
Obesity worsens the outcome of influenza virus infection associated with impaired type I interferon induction in mice

Namkoong H, Ishii M, Fujii H, Asami T, Yagi K, Suzuki S, Azekawa S, Tasaka S, Hasegawa N, Betsuyaku T

Biochemical and Biophysical Research Communications, 513(2) 405-411, May 28, 2019
Retrospective evaluation of natural course in mild cases of Mycobacterium avium complex pulmonary disease

Kimizuka Y, Hoshino Y, Nishimura T, Asami T, Sakakibara Y, Morimoto K, Maeda S, Nakata N, Abe T, Uno S …

PLoS ONE, 14(4) e0216034, Apr, 2019 Peer-reviewed
Disseminated histoplasmosis from a calcified lung nodule after long-term corticosteroid therapy in an elderly Japanese patient: A case report

Kobayashi K, Asakura T, Kawada I, Hasegawa H, Chubachi S, Ohara K, Kuramoto J, Sugiura H, Fujishima S, Iwata S …

Medicine, 98(17) e15264, Apr 1, 2019 Peer-reviewed

Misc.

Editorial Comment to Comparison of single- and multiple-dose cefazolin as prophylaxis for transurethral enucleation of prostate: A multicenter, prospective, randomized controlled trial by the Japanese Research Group for Urinary Tract Infection

Yazawa S, Hasegawa N, Oya M

International Journal of Urology, 27(3) 248-249, Mar 1, 2020
Correction: Low serum estradiol levels are related to Mycobacterium avium complex lung disease: A cross-sectional study (BMC Infectious Diseases (2019) 19 (1055) DOI: 10.1186/s12879-019-4668-x)

Uwamino Y, Nishimura T, Sato Y, Tamizu E, Asakura T, Uno S, Mori M, Fujiwara H, Ishii M, Kawabe H …

BMC Infectious Diseases, 20(1) 131-131, Feb 12, 2020
From the authors

Kwak N, Dalcolmo M.P, Daley C.L, Eather G, Hasegawa N, Koh W.J, Thomson R, Van Ingen J, Yim J.J

European Respiratory Journal, 54(5), Nov 1, 2019

Presentations

エンドトキシン気道内投与のシグナル伝達に対する抗CD14抗体とtoll-like receptor4遺伝子変異の影響

YAMAGUCHI KAZUHIRO

第44回日本呼吸器学会総会, Mar, 2004
エンドトキシン（LPS）投与マウス肺損傷モデルにおける抗VEGF抗体投与の効果

YAMAGUCHI KAZUHIRO

第44回日本呼吸器学会総会, Mar, 2004
日本人軽症喘息患者におけるロイコトリエン受容体拮抗薬反応性規定因子の解析

YAMAGUCHI KAZUHIRO

第44回日本呼吸器学会総会, Mar, 2004
エンドトキシン（LPS）気道内注入肺損傷モデルにおけるTNF-α Converting Enzyme（TACE）阻害薬の効果

YAMAGUCHI KAZUHIRO

第44回日本呼吸器学会総会, Mar, 2004
肺非定型抗酸菌症（MAC）症の治療例における血清KL-6およびSPD値の経時的変化

YAMAGUCHI KAZUHIRO

第44回日本呼吸器学会総会, Mar, 2004
肺癌に合併した非細菌性血栓性心内膜炎の1例

YAMAGUCHI KAZUHIRO

第514回日本内科学会関東地方会, Dec, 2003
Effect of CD14 blockage and Toll-like receptor 4 mutation on NF-κB translocation after intratracheal instillation of LPS in murine lungs

ISHIZAKA AKITOSHI

European respiratory society whole meeting 2003, Sep, 2003
CINC-1 concentration and neutrophil elastase activity are increased in rat ventilator-induced lung injury

ISHIZAKA AKITOSHI

European respiratory society whole meeting 2003, Sep, 2003
Effect of CD14 blockage and Toll-like receptor 4 mutation on NF-κB translocation after intratracheal instillation of LPS in murine lungs.

YAMAGUCHI KAZUHIRO

European Respiratory Society Annual Congress 2003, Sep, 2003
エンドトキシンによるアポトーシス誘導に対する血管内皮増殖因子の抑制効果

ISHIZAKA AKITOSHI

第3回Integrated Pulmonary Circulation Research, Jun, 2003
進行性非小細胞癌に対する併用化学療法におけるドセタキセル投与量の影響

YAMAGUCHI KAZUHIRO

第137回日本肺癌学会関東地方会, Jun, 2003
エンドトキシンによるアポトーシス誘導に対する血管内皮細胞増殖因子の抑制効果

YAMAGUCHI KAZUHIRO

第3回iPCU, Jun, 2003
Vascular endothelial growth factor (VEGF) is protective against acute lung injury

ISHIZAKA AKITOSHI

The 2003 International Conference American Lung Association/American Thoracic Society, May, 2003
エンドトキシンによす血管内皮細胞アポトーシス誘導に対する血管内皮増殖因子の抑制効果

ISHIZAKA AKITOSHI

第18回日本ショック学会, May, 2003
エンドトキシンによる血管内皮細胞のアポトーシス誘導に対する血管内皮増殖因子の抑制効果

YAMAGUCHI KAZUHIRO

第18回日本Shock学会, May, 2003
The usefulness monitoring serum concentrations of pulmonary epithelial markers KL6 and SPD during 18 months chemotherapy for patients with pulmonary Mycobacteria avium complex infection.

YAMAGUCHI KAZUHIRO

2003 ATS International Conference, May, 2003
Vascular endothelial growth factor (VEGF) is protective against acute lung injury.

YAMAGUCHI KAZUHIRO

2003 ATS International Conference, May, 2003
肺抗酸菌症の血清診断の有用性について

YAMAGUCHI KAZUHIRO

100回日本内科学会講演会, Apr, 2003
当院過去6年間における肺炎の起因菌および薬剤耐性についての検討

ISHIZAKA AKITOSHI

第43回日本呼吸器学会総会, Mar, 2003
エンドトキシンのよる血管内皮細胞のアポトーシス誘導に対する血管内皮増殖因子の抑制効果

ISHIZAKA AKITOSHI

第43回日本呼吸器学会総会, Mar, 2003

Teaching Experience

Apr, 2024 - Mar, 2025

LECTURE SERIES, INTERNAL MEDICINE (PULMONOLOGY) (Keio University)
Apr, 2024 - Mar, 2025

INFECTIOUS DISEASES: SEMINAR (Keio University)
Apr, 2024 - Mar, 2025

INFECTIOUS DISEASES: PRACTICE (Keio University)
Apr, 2024 - Mar, 2025

INFECTIOUS DISEASES (Keio University)
Apr, 2024 - Mar, 2025

ADVANCED INFECTIOUS DISEASES (Keio University)
Apr, 2023 - Mar, 2024

INFECTIOUS DISEASES (Keio University)
Apr, 2023 - Mar, 2024

LECTURE SERIES, INTERNAL MEDICINE (PULMONOLOGY) (Keio University)
Apr, 2023 - Mar, 2024

INTRODUCTION TO CLINICAL CLERKSHIPS (Keio University)
Apr, 2023 - Mar, 2024

INFECTIOUS DISEASES: SEMINAR (Keio University)
Apr, 2023 - Mar, 2024

INFECTIOUS DISEASES: PRACTICE (Keio University)
Apr, 2023 - Mar, 2024

CLINICAL TRAINING IN DIAGNOSIS (Keio University)
Apr, 2023 - Mar, 2024

ADVANCED INFECTIOUS DISEASES (Keio University)
Apr, 2022 - Mar, 2023

INFECTIOUS DISEASES (Keio University)
Apr, 2022 - Mar, 2023

PATHOPHYSIOLOGY AND CLINICAL ASSESSMENT (Keio University)
Apr, 2022 - Mar, 2023

LECTURE SERIES, INTERNAL MEDICINE (PULMONOLOGY) (Keio University)
Apr, 2022 - Mar, 2023

INFECTIOUS DISEASES: SEMINAR (Keio University)
Apr, 2022 - Mar, 2023

INFECTIOUS DISEASES: PRACTICE (Keio University)
Apr, 2022 - Mar, 2023

CLINICAL TRAINING IN DIAGNOSIS (Keio University)
Apr, 2022 - Mar, 2023

ADVANCED INFECTIOUS DISEASES (Keio University)
Apr, 2022 - Mar, 2023

RESEARCH FRONTIERS IN BIOMEDICAL SCIENCE (Keio University)

Professional Memberships

Research Projects

Elucidation of pathogenesis of pulmonary diseases due to nontuberculous mycobacteria using the human lungs

Grant-in-Aid for Scientific Research, 基盤研究(B), MEXT,JSPS, Apr, 2022 - Mar, 2025

長谷川直樹
Investigation on pathogenesis of pulmonary diseases due to nontuberculous mycobacteria using human genomic analysis

Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), MEXT,JSPS, Apr, 2019 - Mar, 2022

長谷川直樹
miRNAを介した肺MAC症の病態解明

Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), MEXT,JSPS, Apr, 2016 - Mar, 2019

長谷川直樹