論文

査読有り 国際誌
2018年9月

Glucose and Prolactin Monitoring in Children and Adolescents Initiating Antipsychotic Therapy.

Journal of child and adolescent psychopharmacology
  • Yasuyuki Okumura
  • ,
  • Masahide Usami
  • ,
  • Takashi Okada
  • ,
  • Takuya Saito
  • ,
  • Hideki Negoro
  • ,
  • Noa Tsujii
  • ,
  • Junichi Fujita
  • ,
  • Junzo Iida

28
7
開始ページ
454
終了ページ
462
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1089/cap.2018.0013

OBJECTIVE: We aimed to evaluate glucose and prolactin monitoring in children and adolescents initiating antipsychotic therapy using a nationwide claims database. METHODS: A retrospective 15-month cohort study was conducted using the National Database of Health Insurance Claim Information and Specified Medical Checkups in Japan. Patients aged ≤18 years, who were newly prescribed antipsychotics between April 2014 and March 2015, were followed up for 450 days. Outcomes were the use of glucose and prolactin testing through 15 months after drug initiation (index date) with consideration of persistence with antipsychotic therapy. The incidence proportion of patients monitored was assessed within the following four time windows: baseline (between 30 days before the index date and the index date), at 1-3 months (between 1 and 90 days after the index date), at 4-9 months (between 91 and 270 days after the index date), and at 10-15 months (between 271 and 450 days after the index date). RESULTS: Of 43,608 new users in 6620 medical institutions, the percentage of persistent antipsychotic users was 46.4% at 90 days, 29.7% at 270 days, and 23.8% at 450 days after the index date. The proportion of patients who received monitoring within the baseline period was 13.5% (95% confidence interval [CI], 13.2-13.8) for glucose and 0.6% (95% CI, 0.5-0.6) for prolactin, respectively. The proportion of patients who received glucose monitoring at all time windows decreased to 0.9%. The proportion of patients who received prolactin monitoring by the second time window decreased to 0.1%. CONCLUSIONS: Our study shows that monitoring for glucose and prolactin is infrequent in children and adolescents initiating antipsychotic therapy. Strategies for physicians, patients, and guardians are needed to overcome the barriers in glucose and prolactin monitoring.

リンク情報
DOI
https://doi.org/10.1089/cap.2018.0013
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29889543
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154762
ID情報
  • DOI : 10.1089/cap.2018.0013
  • PubMed ID : 29889543
  • PubMed Central 記事ID : PMC6154762

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