HATA Ryu-ichiro

J-GLOBAL         Last updated: Oct 29, 2019 at 17:12
HATA Ryu-ichiro
Kanagawa Dental College
Oral Health Science Research Center, Kanagawa Dental College
Job title
Distinguished Professor
(BLANK)(Tokyo Medical and Dental University)
Research funding number

Research Areas


Academic & Professional Experience

Distinguished Professor, Oral Health Science Research Center, Kanagawa Dental University
Associate Professor
- Professor
Assistant Professor
Sep 1976
Aug 1977
Visiting Research Fellow, Department of Dentistry,, University of Southern California,
Sep 1974
Sep 1976
Postdoctoral Fellow, National Cancer Institute,, National Institutes of Health,


Graduate School, Division of Medicine, Tokyo Medical and Dental University
Faculty of Science, Tokyo Metropolitan University

Awards & Honors

Expression of the chemokine CXCL14 is a predictive biomarker for cetuximab-dependent tumour suppression, The third award:, The 1st Nature Immunology-Cellular and Molecular Immunology Joint Conference
Winner: HATA Ryu-ichiro et al.,
Production of transgenic mice resistant to cancer cell growth and metastasis -Toward Cancer Therapy using Endogenous Tumor Suppressing Chemokines-, [Outstanding Abstract and Selected Oral Presentation Award], Second International Conference, Cancer Immunotherapy and Immunomonitoring
Winner: HATA Ryu-ichiro et al.,
Mar 2007
Gefitinib reduces tumor mass through BRAK/CXCL14 expression, IADR Hatton Awards Competition 1st prize, 85th International Association of the Dental Research
Winner: HATA Ryu-ichirOzaw S, Kato T, Maehata Y, Komori R, Kubota E, Tsukuda M ad Hata R

Published Papers

Katoh I, Maehata Y, Moriishi K, Hata RI, Kurata SI
Neoplasia (New York, N.Y.)   21(5) 494-503   May 2019   [Refereed]
Yang XY, Ozawa S, Kato Y, Maehata Y, Izukuri K, Ikoma T, Kanamori K, Akasaka T, Suzuki K, Iwabuchi H, Kurata SI, Katoh I, Sakurai T, Kiyono T, Hata RI
International journal of molecular sciences   20(8)    Apr 2019   [Refereed]
Kondo, T., Ozawa, S., Ikoma, T., Yang, X.Y., Kanamori, K ., Suzuki, K., Iwabuchi, H., Maehata, Y., Miyamoto, C., Taguchi, T., Kiyono, T., Kubota, E. & Hata, R.
Oncogenesis   5(e240)    2016   [Refereed]
Yang, X. Y., Miyamoto, C., Akasaka, T, Izukuri, K., Maehata, Y., Ikoma, T., Ozawa, S., Hata, R.
Journal of Oral Biosciences   58 16-22   2016   [Refereed]
Katoh, I., Fukunishi, N., Fujimuro, M., Kasai, H., Moriishi, K., Hata, R. & Kurata, S.
Cell Cycle   15 699-710   2016   [Refereed]
HATA Ryu-ichiroHata, R., Izukuri, K., Kato, Y., Sasaki, S., Mukaida, N., Maehata, Y., Miyamoto, C., Akasaka, T., Yang, X., Nagashima, Y., Takeda, K., Kiyono, T. & Taniguchi, M.
Scientific Report   5(9083)    Mar 2015   [Refereed]
Miyamoto, C., Maehata, Y., Motohashi, K., Ozawa, S., Ikoma, T., Hidaka, K., Wada-Takahashi, S., Takahashi, S. S., Yoshino, F., Yoshida, A., Kubota, E., Hata, R. & Lee, M. C.
Biomedical Research   35 381-388   2014   [Refereed]
Ikoma, T., Ozawa, S., Suzuki, K., Kondo, T., Maehata, Y., Lee, M. C., Hata, R. & Kubota, E.
Biochemical and Biophysical Research Communications   420 217-222   2012   [Refereed]
Miyamoto, C., Maehata, Y., Ozawa, S., Ikoma, T., Kubota, E., Izukuri, K., Kato, Y., Hata, R. & Lee, M. C.
Journal of Pharmaceutical Sciences   120 241-249   2012   [Refereed]
HATA Ryu-ichiroYamamoto, T., Yamashita, A., Yamada, K. & Hata, R.
Neurosci Lett   487 335-340   2011   [Refereed]
Nahoko Fukunishi, I. K., Yoshiya Tomomori, Kenichi Tsukinoki, Hata, R., Atsuhito Nakano, Yoji Ikawa, Shun-ichi Kurata
Neoplasia   12 969-979   2011   [Refereed]
Maehata, Y., Ozawa, S., Kobayashi, K., Kato, Y., Yoshino, F., Miyamoto, C., Izukuri, K., Kubota, E., Hata, R. & Lee, M. C.
Free Radical Research   44 913-924   2011   [Refereed]
Determination of Serum BRAK/CXCL14 Levels in Healthy Volunteers.
HATA Ryu-ichiro
Lab Med   41 478-482   2010   [Refereed]
Ito, S., Ozawa, S., Ikoma, T., Yajima, N., Kiyono, T. & Hata, R.
Biomedical Research   31 199-206   2010   [Refereed]
Yajima, N., Izukuri, K., Hata, R.
Inflammation and Regeneration   30 536-541   2010   [Refereed]
Ozawa, S., Ito, S., Kato, Y., Kubota, E. & Hata, R.
Biochemical Biophysical Research Communications   396 1060-1064   2010   [Refereed]
Komori, R., Ozawa, S., Kato, Y., Shinji, H., Kimoto, S. & Hata, R.
Biomedical Research   31 123-131   2010   [Refereed]
Izukuri, K., Suzuki, K., Yajima, N., Ozawa, S., Ito, S., Kubota, E. & Hata, R.
Transgenic Research   19 1109-1117   2010   [Refereed]
Kazuhito Izukuri, Shin Ito, Naohito Nozaki, Nobuyuki Yajima, Mariko Iwamiya, Sachiko Kawahara, Kenji Suzuki, Eiro Kubota, Ryu-Ichiro Hata
LabMed   41 478-482   2010   [Refereed]
Maehata, Y., Lee, M.C., Hata, R.
Journal of Oral Biosciences   51(2) 72-80   2009
Ozawa, S., Kato, Y., Kubota, E. & Hata, R.
Biomedical Research   30 315-318   2009   [Refereed]
Ozawa, S., Kato, Y., Ito, S., Komori, R., Shiiki, N., Tsukinoki, K., Ozono, S., Maehata, Y., Taguchi, T., Imagawa-Ishiguro, Y., Tsukuda, M., Kubota, E. & Hata, R.
Cancer Sci   100 2202-2209   2009   [Refereed]
Okuyama, T., Kurata, S., Tomimori, Y., Fukunishi, N., Sato, S., Osada, M., Tsukinoki, K., Jin, H. F., Yamashita, A., Ito, M., Kobayashi, S., Hata, R., Ikawa, Y. & Katoh, I.
Oncogene   27 308-317   2008   [Refereed]
Furue, M. K., Na, J., Jackson, J. P., Okamoto, T., Jones, M., Baker, D., Hata, R., Moore, H. D., Sato, J. D. & Andrews, P. W.
Proceedings National Academy of Science U S A   105 13409-13414   2008   [Refereed]
BRAK/CXCL14 expression suppresses tumor growth in vivo in human oral carcinoma cells.
Biochemical Biophysical Research Communications   348(2) 406-412   2006
Inostamycin suppresses vascular endothelial growth factor-stimulated growth and migration of human umbilical vein endothelial cells
21 419-425   2004
Angiogenesis involves multiple steps including proliferation and migration of endothelial cells. In the present study, we determined the effect of inostamycin (an inhibitor of phosphatidylinositol synthesis) on vascular endothelial growth factor (...
Complex gene diseases of the connective tissue
Hata,R., Izukuri,K., Furue, M., Kato, Y., Koshika, S.
Connective Tissue   33 9-16   2001   [Refereed]
Kato, Y., Lewalle, J. M., Baba, Y., Tsukuda, M., Sakai, N., Baba, M., Kobayashi, K., Koshika, S., Nagashima, Y., Frankenne, F., Noel, A., Foidart, J. M. & Hata, R.
Biochemical Biophysical Research Communications   287 422-426   2001   [Refereed]
Furue, M., Zhang, Y., Okamoto, T., Hata, R. & Asashima, M.
Biochemical Biophysical Research Communications   282 745-749   2001   [Refereed]
Hata, R., Akai, J., Kimura, A., Ishikawa, O., Kuwana, M. & Shinkai, H.
Biochemical Biophysical Research Communications   272 36-40   2000   [Refereed]
Insoluble extracellular matrix gives positional information to cells and regulates morphogenesis as a morphocreator
Ryu-Ichiro Hata
Connective Tissue   30 285-289   1998   [Refereed]
Fine structural analysis of the unique 5'region of the human COL1A2 gene containing two regions of dinucleotide repeats adjacent to the transcriptional start site.
Akai, J., Kimura, A., Arai, K., Uehara, K. and Hata, R.
Connective Tissue   30 285-289   1998   [Refereed]
Tamamori, M., Ito, H., Hiroe, M., Marumo, F. & Hata, R.
Cell Biology International   21 175-180   1997   [Refereed]
Regulation of Gene Expression and Cell Differentiation by Ascorbic Acid (Vitamin C)
HATA Ryu-ichiro
Gene Expression and Nutrition ( Ed. T. Muramatsu ) Research Signpost Co., Trivandrum   1-23   1997   [Refereed]
Senoo, H., Imai, K., Sato, M., Kojima, N., Miura, M. & Hata, R.
Cell Biology International   20 56-65   1996   [Refereed]
Hata, R.
Cell Biol Int   20 59-65   1996   [Refereed][Invited]
Transfection of normal human skin fibroblasts with human alpha 1(I) and alpha 2(I) collagen gene constructs and evidence for their coordinate expression.
Hata, R., Akai, J. & Kimura, A.
Cell Biology International   19 735-741   1995   [Refereed]
Hata, R. & Senoo, H.
Tissue Culture Research Communications   11 337-343   1992   [Refereed]
Simultaneous expression of type I procollagen mRNA and albumin in cirrhotic human liver.
Yamada, S., Koji, T., Hata, R., Hirohashi, S., Kurata, S., Senoo, H., Sakakibara, K., Hayashi, T. & Nakane, P. K.
Journal of Clinical Laboratory Analysis   6 351-358   1992   [Refereed]
Epidermal growth factor inhibits transcription of type I collagen genes and production of type I collagen in cultured human skin fibroblasts in the presence and absence of L-ascorbic acid 2-phosphate, a long-acting vitamin C derivative.
Kurata, S. & Hata, R.
J Biol Chem   266 9997-10003   1991   [Refereed]
Age-dependent changes in collagen metabolism and response to hypertonic culture conditions of rat aortic smooth muscle cells and skin fibroblasts.
HATA Ryu-ichiro
Cell Biology International Reports   14 25-33   1990   [Refereed]
Epidermal growth factor regulates gene expression of both epithelial and mesenchymal cells in mouse molar tooth organs in culture.
Hata, R., Bessem, C., Bringas, P., Jr., Hsu, M. Y. & Slavkin, H. C.
Cell Biology International Reports   14 509-519   1990   [Refereed]
Kobayashi, K., Hata, R., Nagai, S., Niwa, J. & Hoshino, T.
Biochemical Biophysical Research Communications   172 217-222   1990   [Refereed]
Co-culture of fibroblasts and hepatic parenchymal cells induces metabolic changes and formation of a three-dimensional structure.
Senoo, H., Tsukada, Y., Sato, T. & Hata, R.
Cell Biology International Reports   13 197-2006   1989   [Refereed]
Hata, R., Kurata, S. & Shinkai, H.
European Journal of Biochemistry   174 231-237   1988   [Refereed]
Hata, R., Sunada, H., Arai, K., Sato, T., Ninomiya, Y., Nagai, Y. & Senoo, H.
Eur. J. Biochem.   173(2) 261-267   1988   [Refereed]
Hata, R., Ninomiya, Y., Sano, J., Konomi, H., Hori, H., Sunada, H., Tanaka, S., Kabuki, K., Nagai, Y. & Tsukada, Y.
Journal of Cellular Physiology   122 333-342   1985   [Refereed]
Hepatocytes (hepatic parenchymal cells) produce a major part of liver collagen in vivo.
Hata, R. & Ninomiya, Y.
Biochemistry International   8 181-186   1984   [Refereed]
Reciprocal effects of excess potassium salts in the culture medium on type I and type III collagen synthesis by human skin fibroblasts.
Hata, R., Sunada, H. & Arai, K.
Cell Biology International Reports   8 433-440   1984   [Refereed]
Senoo, H., Hata, R., Nagai, Y. and Wake, K.
Biomedical Research   5 451-458   1984   [Refereed]
Ohsawa, S., Hori, H., Hata, R. & Nagai, Y.
Biomedical Research   5 177-186   1984   [Refereed]
Selective inhibition of type I collagen synthesis in osteoblastic cells by epidermal growth factor
Hata, R., Hori, H., Nagai, Y., Tanaka, S., Kondo, M., Hiramatsu, M., Utsumi, N. & Kumegawa, M. Selective
EGF AND COLLAGEN METABOLISM   115(3) 867-876   1984   [Refereed]
Hata, R., Sunada, H. & Nagai, Y.
Biochemical Biophysical Research Communications   117 313-318   1983   [Refereed]
Nagai, Y., Hori, H., Hata, R., Konomi, H. and Sunada, H.
Biomedical Research   3 345-349   1982   [Refereed]
Ninomiya, Y., Hata, R., Nagai, Y., Tajima, S., Nishikawa, T. and Hatano, H.
Biomedical Research   3 70-82   1982   [Refereed]
Konomi, H., Hata, R., Sano, J., Sunada, H. and Nagai, Y.
Biomedical Research   3 341-344   1982   [Refereed]
Two-dimensional electrophoresis of the alpha-chains of collagens and its application to the determination of their isoelectric points.
Tanaka, S., Hata, R. & Nagai, Y.
Collagen and Related Research   1 237-246   1981   [Refereed]
Two-dimensional electrophoresis patterns of the CNBr peptides of collagen types I, II, III and V.
Tanaka, S., Hata, R. & Nagai, Y.
Collagen and Related Research   1 445-452   1981   [Refereed]
Hata, R., Ninomiya, Y., Nagai, Y. & Tsukada, Y.
Biochemistry   19 169-176   1980   [Refereed]
Active synthesis of glycosaminoglycans by liver parenchymal cell in primary culture.
Ninomiya, Y., Hata, R. & Nigai, Y.
Biochimica Biophysica Acta   629 349-358   1980   [Refereed]
Immunohistochemical localization of type I, II, III, and IV collagens in the lung.
Konomi, H., Hori, H., Sano, J., Sunada, H., Hata, R., Fujiwara, S. & Nagai, Y.
Acta Pathologica Japonica   31 601-610   1980   [Refereed]
Glycosaminoglycan synthesis by liver parenchymal cell clones in culture and its change with transformation.
Ninomiya, Y., Hata, R. & Nagai, Y.
Biochimica Biophysica Acta   629 349-358   1980   [Refereed]
Differentiation of hepatocytes into type I collagen producing cells during primary culture in the presence of aphidicolin(Inhibitor of DNA polymerase a)
Hata, R. & Nagai, Y.
Biochemistry International   1 567-573   1980   [Refereed]
Hata, R., Ninomiya, Y., Nagai, Y. and Tsukada, Y.
Proceedings of the Japan Academy   55,Ser.B, 531-536   1979   [Refereed]
Hata, R., Ninomiya,Y., Nagai, Y., Sakakibara, K. and Tsukada,Y.
Proceedings of the Japan Academy 54, Ser. B   54 391-396   1978   [Refereed]
A low-sulfated chondroitin sulfate in rat blood: an acidic glycosaminoglycan with a high metabolic rate.
Hata, R. & Nagai, Y.
Biochimica Biophysica Acta   543 149-155   1978   [Refereed]
Low-sulfated chondroitin sulfate in human blood and urine. Biochim Biophys Acta
Hata, R., Ohkawa, S. I. & Nagai, Y.
Biochim Biophys Acta   543 156-166   1978   [Refereed]
Retention of transformant specific type III collagen in dibutyryl cAMP treated Kirsten sarcoma virus transformed BALB 3T3 cells and in a flat revertant.
Hata, R. & Peterkofsky, B.
Journal Cellular Physiology   95 343-352   1978   [Refereed]
De novo induction of a gene product during heterologous epithelial-mesenchymal interactions in vitro.
Hata, R. & Slavkin, H. C.
Proceedings National Academy of Sciences USA   75 2790-2794   1978   [Refereed]
Specific changes in the collagen phenotype of BALB 3T3 cells as a result of transformation by sarcoma viruses or a chemical carcinogen
Hata, R. & Peterkofsky, B.
Proceedings National Academy of Sciences USA   74 2933-2937   1977   [Refereed]
Acidic glycosaminoglycans in urine, serum and myocardium of aged patients with myocardial infarction.
Ohkawa, S. I., Sugiura, M., Hata, R. & Nagai, Y.
Journal of Molecular and Cellular Cardiology   9 541-550   1977   [Refereed]
A micro colorimetric determination of acidic glycosaminoglycans by two dimensional electrophoresis on a cellulose acetate strip.
Hata, R. & Nagai, Y.
Analytical Biochemistry   52 652-656   1973   [Refereed]
Heterogeneity of hemoglobin from Arca (Anadara satowi). Molecular weights and oxygen equilibria of Arca Hb I and II.
Onoki, S., Mitomi, Y., Hata, R. & Satake, K.
J Biochem   73 717-725   1973   [Refereed]
Distribution of acidic glycosaminoglycans in tadpole back skin.
Hata, R. & Nagai, Y.
Biochimica Biophysica Acta   304 408-412   1973   [Refereed]
Urinary excretion of acidic glycosaminoglycans in the aged.
Okawa, S., Hata, R., Nagai, Y. & Sugiura, M.
Journal of Biochemistry   72 1495-1501   1972   [Refereed]
A rapid and micro method for separation of acidic glycosaminoglycans by two-dimensional electrophoresis.
Hata, R. & Nagai, Y.
Analytical Biochemistry   45 462-468   1972   [Refereed]


Toshiharu Yamamoto, Anzu Yamashita, Kentaro Yamada, Ryu-Ichiro Hata
Neurosci Lett.   487(3) 335-340   2011
Yojiro Maehata, Shigeyuki Ozawa, Kyo Kobayashi, Yasumasa Kato, Fumihiko Yoshino, Chihiro Miyamoto, Kazuhito Izukuri, Eiro Kubota, Ryu-Ichiro Hata, Masaichi-Chang-il Lee
Free Radical Res   44(8) 913-924   2010
Shin Ito, Shigeyuki Ozawa, Takeharu Ikoma, Nobuyuki Yajima, Tohru Kiyono, and Ryu-Ichiro Hata
Biomedical Research   31(3) 199-206   2010
Izukuri K., Suzuki K., Yajima N., Ozawa S., Ito S., Kubota E., Hata R
Transgenic Res   19(6) 1109-17   2010
Biochemical and Biophysical Research Communications   272(1) 36-40   2000
畑 隆一郎,妹尾春樹
日経サイエンス創刊20周年記念論文優秀賞受賞論文   88-97   1992   [Refereed]
Regulation of cell gowthby extracellular matrix
Ryu-Ichiro Hata
36(7) 107-115   1991   [Refereed][Invited]
Epidermal Growth Factor Inhibits Transcription of Type I Collagen and Production of Type I Collagen in Cultured Human Skin Fibroblasts in the Presence and Absence of L-Ascorbic Acid 2-Phosphate, a Long-acting Vitamin C Derivative
THE JOURNAL OF BIOLOGICAL CHEMISTRY   266(15) 9997-10003   1991
畑 隆一郎
18 843-857   1973

Books etc

Provitamin C
HATA Ryu-ichiro
May 2014   
Pathogenesis and Management of Scleroderma and Connective Tissue Disorders
Hata R., Horikawa S., Kurata S., Senoo H., Tsukada K. (Part:Contributor, Transcriptional regulation of type I collagen genes in normal and pathologic human skin fibroblasts.)
Scleroderma Research Committee   1994   
久保木芳徳,畑 隆一郎,吉里勝利 (Part:Editor)


Studies on the Formation of Three dimensional Tissue from Isolated Cells by using Ascorbic Phosphate

Research Grants & Projects

Functions of Extracellular Matrix
Regulation of Collagen Gene Expression
Regulation of Organ Formation by Ascorbic Acid Phosphate
Cancer Suppresser
Project Year: 2003   
Tumor supressor
Project Year: 2004