MISC

1996年1月

Prognostic indicators of major cardiac events in patients with asymptomatic coronary artery disease

JAPANESE HEART JOURNAL
  • H Kishida
  • T Saitoh
  • J Sano
  • Y Tada
  • A Hanashi
  • N Fukuma
  • Y Tsukada
  • M Sekido
  • H Homma
  • Y Miyatake
  • Y Tomita
  • Y Kusama
  • 全て表示

37
1
開始ページ
59
終了ページ
72
記述言語
英語
掲載種別
DOI
10.1536/ihj.37.59
出版者・発行元
JAPAN HEART JOURNAL, SECOND DEPT OF INTERNAL MED

We investigated the role of myocardial ischemia in acute myocardial infarction and cardiac death in 253 patients with asymptomatic coronary disease (206 men, 47 women, mean age: 55 +/- 8 years). Patients were divided into two groups: those with angina pectoris with no history of myocardial infarction (AP group, 93 patients) and those with a history of myocardial infarction CMI group, 160 patients). We also examined the usefulness of exercise electrocardiographic and Holter electrocardiographic findings as prognostic indicators of cardiac events. After 24-hour Holter electrocardiograms were obtained in both groups, patients were assigned to subgroups with or without silent myocardial ischemia (SMI) based on the presence or absence of transient ST-segment depression. Prognostic indicators were evaluated by multiple regression analysis. Cardiac events occurred in 26 (10.3%) of 253 patients; in 6 patients these events were fatal. The incidence of cardiac events was significantly higher in the SMI group than in the non-SMI group (16.4% versus 5.6%, P < 0.05). SMI was identified as a significant prognostic indicator in the overall population (p = 0.0088), as were the number of diseased coronary arteries in the AP group (P = 0.0152), and SMI (p = 0.0022) in the MI group. There were 3 deaths related to cardiac events in each group. The mean time from onset of angina pectoris to death was 73 +/- 41 months compared with 33 +/- 43 months in the MI group. Our findings suggest that the severity of the coronary lesion and SMI were important predictors of major cardiac events, and that the mechanism of the onset of cardiac events was different in the AP and MI groups.

リンク情報
DOI
https://doi.org/10.1536/ihj.37.59
CiNii Articles
http://ci.nii.ac.jp/naid/130000766443
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/8632626
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1996UA10500005&DestApp=WOS_CPL
ID情報
  • DOI : 10.1536/ihj.37.59
  • ISSN : 0021-4868
  • CiNii Articles ID : 130000766443
  • PubMed ID : 8632626
  • Web of Science ID : WOS:A1996UA10500005

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