KARASUYAMA Hajime

J-GLOBAL         Last updated: Apr 18, 2019 at 03:57
 
Avatar
Name
KARASUYAMA Hajime
E-mail
karasuyama.mbchtmd.ac.jp
URL
http://immune-regulation.org/index.php?id=27
Affiliation
Tokyo Medical and Dental University
Section
Board Member
Job title
Executive Director
Degree
MD., PhD.(The University of Tokyo)
Other affiliation
Tokyo Medical and Dental University
Research funding number
60195013

Research Areas

 
 

Academic & Professional Experience

 
 
   
 
1978 Tokyo Medical and Dental University School of Medicine MD.1978
 
 
   
 
1980-1984 Postgraduate, Department of Immunology, Faculty of Medicine, University of Tokyo
 
 
   
 
PhD., 1984.
 
 
   
 
1984-1987 Scientific member, Basel Institute for Immunology, Basel, Switzerland
 
 
   
 
1987-1990 Research Associate, Department of Immunology, Faculty of Medicine, University of Tokyo
 

Education

 
 
 - 
1984
Graduate School, Division of Medical Sciences, The University of Tokyo
 
 
 - 
1978
Faculty of Medicine, Tokyo Medical and Dental University
 

Committee Memberships

 
 
   
 
Japanese Society for Immunology  Board member
 
 
   
 
Japanese Society of Allergology  Board of representatives
 

Published Papers

 
Sho Shibata, Kensuke Miyake, Tomoya Tateishi, Soichiro Yoshikawa, Yoshinori Yamanishi, Yasunari Miyazaki, Naohiko Inase, Hajime Karasuyama
Proc. Natl. Acad. Sci. U.S.A.   115(51) 13057-13062   Dec 2018   [Refereed]
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. It has generally been considered a non-Th2-type lung disorder, characterized by progressive airflow limitation with inflammation and emphysema, b...
Nagao T, Yamanishi Y, Miyake K, Teranishi M, Takahashi S, Yoshikawa S, Kawano Y, Karasuyama H
International immunology      Sep 2018   [Refereed]
Yuya Tabakawa, Takuya Ohta, Soichiro Yoshikawa, Elisabeth J Robinson, Kayoko Yamaji, Kenji Ishiwata, Yohei Kawano, Kensuke Miyake, Yoshinori Yamanishi, Hiroshi Ohtsu, Takahiro Adachi, Naohiro Watanabe, Hirotaka Kanuka, Hajime Karasuyama
Front Immunol   9 1540-1540   Jul 2018   [Refereed]
ticks, both mast cells and basophils reportedly play key roles in the manifestation of acquired tick resistance (ATR), but it remains ill-defined how they contribute to it. Here, we investigated their products responsible for ATR. Treatment of mic...
Yohei Kawano, Georg Petkau, Christina Stehle, Pawel Durek, Gitta Anne Heinz, Kousuke Tanimoto, Hajime Karasuyama, Mir-Farzin Mashreghi, Chiara Romagnani, Fritz Melchers
Blood   131(18) 2026-2035   May 2018   [Refereed]
Common lymphoid progenitors (CLPs) differentiate to T and B lymphocytes, dendritic cells, natural killer cells, and innate lymphoid cells. Here, we describe culture conditions that, for the first time, allow the establishment of lymphoid-restricte...
Christophe Pellefigues, Barbara Dema, Yasmine Lamri, Fanny Saidoune, Nathalie Chavarot, Charlotte Lohéac, Emeline Pacreau, Michael Dussiot, Caroline Bidault, Florian Marquet, Mathieu Jablonski, Jonathan M Chemouny, Fanny Jouan, Antoine Dossier, Marie-Paule Chauveheid, Delphine Gobert, Thomas Papo, Hajime Karasuyama, Karim Sacré, Eric Daugas, Nicolas Charles
Nat Commun   9(1) 725-725   Feb 2018   [Refereed]
In systemic lupus erythematosus (SLE), autoantibody production can lead to kidney damage and failure, known as lupus nephritis. Basophils amplify the synthesis of autoantibodies by accumulating in secondary lymphoid organs. Here, we show a role fo...

Misc

 
Hajime Karasuyama, Yuya Tabakawa, Takuya Ohta, Takeshi Wada, Soichiro Yoshikawa
Front Physiol   9 1769-1769   Dec 2018   [Refereed]
infestation, IgE-armed basophils are recruited to tick-feeding sites and stimulated by tick saliva antigens to release histamine that promotes epidermal hyperplasia, contributing to ATR. Further studies are needed to clarify whether this scenario ...
Karasuyama Hajime, Miyake Kensuke, Yoshikawa Soichiro, Kawano Yohei, Yamanishi Yoshinori
INTERNATIONAL IMMUNOLOGY   30(9) 391-396   Sep 2018   [Refereed]
Hajime Karasuyama, Kensuke Miyake, Soichiro Yoshikawa, Yoshinori Yamanishi
J. Allergy Clin. Immunol.   142(2) 370-380   Aug 2018   [Refereed]
Until recently, basophils had often been neglected in immunologic studies because of their minority status among immune cells or confused with tissue-resident mast cells because of some phenotypic similarities between them in spite of different an...
Allergy: Allergic dermatitis, food allergy and allergic conjunctivitis Basophil tryptase mMCP-11 plays a crucial role in IgE-mediated, delayed-onset allergic inflammation(和訳中)
Yamanishi Yoshinori, Iki Misako, Tanaka Kensei, Deki Hayato, Fujimaki Mio, Miyake Kensuke, Yoshikawa Soichiro, Kawano Yohei, Sato Shingo, Karasuyama Hajime
日本免疫学会総会・学術集会記録   46(Proceedings) 2-G   Dec 2017   [Refereed]
B cell development and function Intravital imaging of Ca2+ signals in lymphocytes of the Ca2+ biosensor YC3.60 transgenic mice(和訳中)
Takahiro Adachi, Yoshikawa Soichiro, Karasuyama Hajime
日本免疫学会総会・学術集会記録   46(Proceedings) 3-E   Dec 2017   [Refereed]

Conference Activities & Talks

 
Basophils promote monocyte differentiation to M2-like macrophages that display enhanced capacity of allergen clearance
Kensuke Miyake, Ayako Fukui, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama
The 47th Annual Meeting of The Japanese Society for Immunology   11 Dec 2018   
Histamine Released From Skin-Infiltrating Basophils but not mast cells is crucial for acquired tick resistance in mice
Soichiro Yoshikawa, Yuya Tabakawa, Takuya Ohta, Kayoko Yamaji, Kenji Ishiwata, Yohei Kawano, Yoshinori Yamanishi, Hiroshi Ohtsu, Takahiro Adachi, Naohiro Watanabe, Hirotaka Kanuka, Hajime Karasuyama
The 47th Annual Meeting of The Japanese Society for Immunology   11 Dec 2018   
Aggregation makes a protein allergenic at the challenge phase of basophil-mediated allergy in mice
Toshihisa Nagao, Yoshinori Yamanishi, Kensuke Miyake, Mio Teranishi, Soichiro Yoshikawa, Yohei Kawano, Hajime Karasuyama
The 47th Annual Meeting of The Japanese Society for Immunology   11 Dec 2018   
Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors
Yohei Kawano, Georg Petkau, Christina Stehle, Pawel Durek, Gitta Anne Heinz, Kousuke Tanimoto, Hajime Karasuyama, Mir-Farzin Mashreghi, Chiara Romagnani, Fritz Melchers
The 47th Annual Meeting of The Japanese Society for Immunology   10 Dec 2018   The Japanese Society for Immunology
Roles for basophils in Th2 immune responses [Invited]
Hajime Karasuyama
The 32nd CIA   2 Oct 2018   

Teaching Experience

 
 

Research Grants & Projects

 
Genetic origins and pathogenesis of primary immunodeficiencies
Roles of basophils in protective immunity, immune regulation and allergy
Cellular and molecular basis of chronic allergic inflammation
Molecular mechanisms for regulation of lymphocyte development