MISC

2009年7月

TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
  • Hiroyuki Kayamuro
  • ,
  • Yasuo Yoshioka
  • ,
  • Yasuhiro Abe
  • ,
  • Kazufumi Katayama
  • ,
  • Tokuyuki Yoshida
  • ,
  • Kohei Yamashita
  • ,
  • Tomoaki Yoshikawa
  • ,
  • Takachika Hiroi
  • ,
  • Norio Itoh
  • ,
  • Yuichi Kawai
  • ,
  • Tadanori Mayumi
  • ,
  • Haruhiko Kamada
  • ,
  • Shin-ichi Tsunoda
  • ,
  • Yasuo Tsutsumi

384
3
開始ページ
296
終了ページ
300
記述言語
英語
掲載種別
DOI
10.1016/j.bbrc.2009.04.115
出版者・発行元
ACADEMIC PRESS INC ELSEVIER SCIENCE

The identification of cytokine adjuvants capable of inducing an efficient mucosal immune response against vital pathogens has been long anticipated. Here, we attempted to identify the potential of tumor necrosis factor superfamily (TNFS) cytokines to function as mucosal vaccine adjuvants. Sixteen different TNFS cytokines were used to screen mucosal vaccine adjuvants, after which their immune responses were compared. Among the TNFS cytokines, intranasal immunization with OVA plus APRIL, TL1A, and TNF-alpha, exhibited stronger immune response than those immunized with OVA alone. TL1A induced the strongest immune response and augmented OVA-specific IgG and IgA responses in serum and mucosal compartments, respectively. The OVA-specific immune response of TL1A was characterized by high levels of serum IgG1 and increased production of IL-4 and IL-5 from splenocytes of immunized mice, Suggesting that TLIA might induce Th2-type responses. These findings indicate that TL1A has the most potential as a mucosal adjuvant among the TNFS cytokines. (C) 2009 Published by Elsevier Inc.

Web of Science ® 被引用回数 : 13

リンク情報
DOI
https://doi.org/10.1016/j.bbrc.2009.04.115
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/19406102
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000266647400005&DestApp=WOS_CPL

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