MISC

2009年1月

Upregulation of S100 calcium-binding protein A9 is required for induction of smooth muscle cell proliferation by a periodontal pathogen

FEBS LETTERS
  • Hiroaki Inaba
  • ,
  • Kazuya Hokamura
  • ,
  • Kazuhiko Nakano
  • ,
  • Ryota Nomura
  • ,
  • Kazufumi Katayama
  • ,
  • Atsushi Nakajima
  • ,
  • Hideo Yoshioka
  • ,
  • Kazuhiro Taniguchi
  • ,
  • Yoshinori Kamisaki
  • ,
  • Takashi Ooshima
  • ,
  • Kazuo Umemura
  • ,
  • Ferid Murad
  • ,
  • Koichiro Wada
  • ,
  • Atsuo Amano

583
1
開始ページ
128
終了ページ
134
記述言語
英語
掲載種別
DOI
10.1016/j.febslet.2008.11.036
出版者・発行元
ELSEVIER SCIENCE BV

We investigated the effect of a periodontal pathogen, Porphyromonas gingivalis, on human aortic smooth muscle cell (hAOSMC) proliferation as mechanisms of atherosclerosis. Cultured hAOSMCs exposed to the supernatant of plasma incubated with P. gingivalis showed a marked transformation from a contractile to proliferative phenotype, resulting in enhancement of cell growth. DNA micro-array analysis revealed a P. gingivalis-dependent upregulation of S100A9 in hAOSMCs. Small interference-RNA for S100A9 dramatically attenuated the effect of P. gingivalis on transformation and proliferation of hAOSMCs. Our data suggested that upregulation of S100A9 mediated by P. gingivalis is an important event in the development of aortic intimal hyperplasia. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

Web of Science ® 被引用回数 : 39

リンク情報
DOI
https://doi.org/10.1016/j.febslet.2008.11.036
CiNii Articles
http://ci.nii.ac.jp/naid/80020082885
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/19059406
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000261949200023&DestApp=WOS_CPL

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