2004年6月
Cellular stresses induce the nuclear accumulation of importin alpha and cause a conventional nuclear import block
JOURNAL OF CELL BIOLOGY
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- 巻
- 165
- 号
- 5
- 開始ページ
- 617
- 終了ページ
- 623
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1083/jcb.200312008
- 出版者・発行元
- ROCKEFELLER UNIV PRESS
We report here that importin alpha accumulates reversibly in the nucleus in response to cellular stresses including UV irradiation, oxidative stress, and heat shock. The nuclear accumulation of importin a appears to be triggered by a collapse in the Ran gradient, resulting in the suppression of the nuclear export of importin alpha. In addition, nuclear retention and the importin beta/Ran-independent import of importin alpha also facilitate its rapid nuclear accumulation. The findings herein show that the classical nuclear import pathway is down-regulated via the removal of importin alpha from the cytoplasm in response to stress. Moreover, whereas the nuclear accumulation of heat shock cognate 70 is more sensitive to heat shock than the other stresses, importin alpha is able to accumulate in the nucleus at all the stress conditions tested. These findings suggest that the stress-induced nuclear accumulation of importin alpha can be involved in a common physiological response to various stress conditions.
- リンク情報
- ID情報
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- DOI : 10.1083/jcb.200312008
- ISSN : 0021-9525
- Web of Science ID : WOS:000221986200003