2007年9月
Heparan sulfate is a binding molecule but not a receptor for CEACAM1-independent infection of murine coronavirus
VIROLOGY
- ,
- ,
- 巻
- 366
- 号
- 1
- 開始ページ
- 16
- 終了ページ
- 22
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.virol.2007.06.034
- 出版者・発行元
- ACADEMIC PRESS INC ELSEVIER SCIENCE
A highly neurovirulent mouse hepatitis virus (MHV) JHMV strain (wt) with receptor (MHVR)-independent infection activity and its low-virulent mutant srr7 without such activity were found to attach to MHVR-negative, non-permissive BHK cells. To identify the molecule that interacts with JHMV, we focused on heparan sulfate (HS) since it works as a receptor of a mutant MHV-recl that infects in an MHVR-independent fashion. The present study indicates that HS interacts with both wt JHMV and srr7 but it does not function as an entry receptor as it apparently does for MHV-rec1. Furthermore, HS failed to serve as an entry receptor in the MHVR-independent infection of wt JHMV, indicating that HS is not a host factor that wt JHMV utilizes in an MHVR-independent infection. (c) 2007 Elsevier Inc. All rights reserved.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.virol.2007.06.034
- CiNii Articles
- http://ci.nii.ac.jp/naid/80018232234
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/17692355
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000249414900003&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1016/j.virol.2007.06.034
- ISSN : 0042-6822
- CiNii Articles ID : 80018232234
- PubMed ID : 17692355
- Web of Science ID : WOS:000249414900003