KAWAOKA Yoshihiro

J-GLOBAL         Last updated: Oct 16, 2018 at 14:23
 
Avatar
Name
KAWAOKA Yoshihiro
Affiliation
The University of Tokyo
Section
The Institute of Medical Science, Division of Virology, Department of Microbiology and Immunology, Division of Virology
Degree
DVM., Ph. D.(Hokkaido University)

Research Interests

 
 

Research Areas

 
 

Education

 
 
 - 
1980
Graduate School, Division of Veterinary Medicine, Hokkaido University
 
 
 - 
1978
Faculty of Veterinary Medicine, Hokkaido University
 

Awards & Honors

 
2016
Fellow of the American Academy of Microbiology
 
2016
Japan Academy Prize
 
2015
UNESCO Carlos J. Finlay Prize for Microbiology
 
2014
Excellence in Research Award, Association of American Veterinary Medical Colleges
 
Apr 2013
Foreign Associate of the United States National Academy of Sciences
 

Published Papers

 
Wu NC, Yamayoshi S, Ito M, Uraki R, Kawaoka Y, Wilson IA
Cell host & microbe   24(4) 569-578.e4   Oct 2018   [Refereed]
Hatta M, Zhong G, Chiba S, Lopes TJS, Neumann G, Kawaoka Y
Emerging infectious diseases   24(10) 1910-1913   Oct 2018   [Refereed]
Yamayoshi S, Yasuhara A, Ito M, Uraki R, Kawaoka Y
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology   108 105-111   Sep 2018   [Refereed]
Saphire EO, Schendel SL, Fusco ML, Gangavarapu K, Gunn BM, Wec AZ, Halfmann PJ, Brannan JM, Herbert AS, Qiu X, Wagh K, He S, Giorgi EE, Theiler J, Pommert KBJ, Krause TB, Turner HL, Murin CD, Pallesen J, Davidson E, Ahmed R, Aman MJ, Bukreyev A, Burton DR, Crowe JE Jr, Davis CW, Georgiou G, Krammer F, Kyratsous CA, Lai JR, Nykiforuk C, Pauly MH, Rijal P, Takada A, Townsend AR, Volchkov V, Walker LM, Wang CI, Zeitlin L, Doranz BJ, Ward AB, Korber B, Kobinger GP, Andersen KG, Kawaoka Y, Alter G, Chandran K, Dye JM, Viral Hemorrhagic Fever Immunotherapeutic Consortium.
Cell   174(4) 938-952.e13   Aug 2018   [Refereed]
Gunn BM, Yu WH, Karim MM, Brannan JM, Herbert AS, Wec AZ, Halfmann PJ, Fusco ML, Schendel SL, Gangavarapu K, Krause T, Qiu X, He S, Das J, Suscovich TJ, Lai J, Chandran K, Zeitlin L, Crowe JE Jr, Lauffenburger D, Kawaoka Y, Kobinger GP, Andersen KG, Dye JM, Saphire EO, Alter G
Cell host & microbe   24(2) 221-233.e5   Aug 2018   [Refereed]
Hatta Y, Boltz D, Sarawar S, Kawaoka Y, Neumann G, Bilsel P
Vaccine   36(33) 5097-5103   Aug 2018   [Refereed]
Halfmann P, Hill-Batorski L, Kawaoka Y
The Journal of infectious diseases      Jul 2018   [Refereed]
Oishi K, Yamayoshi S, Kozuka-Hata H, Oyama M, Kawaoka Y
Cell reports   24(4) 851-860   Jul 2018   [Refereed]
Ueki H, Wang IH, Fukuyama S, Katsura H, da Silva Lopes TJ, Neumann G, Kawaoka Y
Proceedings of the National Academy of Sciences of the United States of America   115(28) E6622-E6629   Jul 2018   [Refereed]
Imai H, Dinis JM, Zhong G, Moncla LH, Lopes TJS, McBride R, Thompson AJ, Peng W, Le MTQ, Hanson A, Lauck M, Sakai-Tagawa Y, Yamada S, Eggenberger J, O'Connor DH, Suzuki Y, Hatta M, Paulson JC, Neumann G, Friedrich TC, Kawaoka Y
Emerging infectious diseases   24(7) 1128-1238   Jul 2018   [Refereed]
Soni P, Yasuhara A, Takenaga T, Iwatsuki-Horimoto K, Uraki R, Ito M, Sasaki T, Ikuta K, Yamayoshi S, Kawaoka Y
The Journal of veterinary medical science   80(6) 1020-1024   Jun 2018   [Refereed]
Kuwahara T, Takashita E, Fujisaki S, Shirakura M, Nakamura K, Kishida N, Takahashi H, Suzuki N, Kawaoka Y, Watanabe S, Odagiri T
Japanese journal of infectious diseases   71(3) 234-238   May 2018   [Refereed]
Hatakeyama D, Shoji M, Yamayoshi S, Yoh R, Ohmi N, Takenaka S, Saitoh A, Arakaki Y, Masuda A, Komatsu T, Nagano R, Nakano M, Noda T, Kawaoka Y, Kuzuhara T
The Journal of biological chemistry   293(19) 7126-7138   May 2018   [Refereed]
Fujihira H, Usami K, Matsuno K, Takeuchi H, Denda-Nagai K, Furukawa JI, Shinohara Y, Takada A, Kawaoka Y, Irimura T
Scientific reports   8(1) 5495   Apr 2018   [Refereed]
Yamayoshi S, Kiso M, Yasuhara A, Ito M, Shu Y, Kawaoka Y
Emerging infectious diseases   24(4) 746-750   Apr 2018   [Refereed]
Maemura T, Fukuyama S, Sugita Y, Lopes TJS, Nakao T, Noda T, Kawaoka Y
The Journal of infectious diseases   217(9) 1372-1382   Apr 2018   [Refereed]
Watanabe T, Iwatsuki-Horimoto K, Kiso M, Nakajima N, Takahashi K, Jose da Silva Lopes T, Ito M, Fukuyama S, Hasegawa H, Kawaoka Y
Scientific reports   8(1) 4801   Mar 2018   [Refereed]
Matsui K, Ozawa M, Kiso M, Yamashita M, Maekawa T, Kubota M, Sugano S, Kawaoka Y
Scientific reports   8(1) 4631   Mar 2018   [Refereed]
Oishi K, Yamayoshi S, Kawaoka Y
Virology   516 71-75   Mar 2018   [Refereed]
Nakatsu S, Murakami S, Shindo K, Horimoto T, Sagara H, Noda T, Kawaoka Y
Journal of virology   92(6)    Mar 2018   [Refereed]

Misc

 
Ogino M, Ebihara H, Lee BH, Araki K, Lundkvist A, kawaoka Y, Yoshimatsu K, Arikawa J. Use of Vesicular Stomatitis Virus Pseudotypes Bearing Hantaan or Seoul Virus Envelope Proteins in a Rapid and Safe Neutralization Test.
Clin Diagn Lab Immunol   10 154-160   2003
Neumann G, Whitt MA, Kawaoka Y. A Decade After the Generation of a Negative-Sense RNA virus From Cloned cDNA-what Have we learned?
J Gen Virol   83 2635-2662   2002
Neumann G, Kawaoka Y. Generation of Influenza A Virus from cloned cDNAs-historical perspective and out look for the new millennium.
Rev Med Virol   12 13-30   2002
Ninomiya A, Ogasawara K, Kajino K, Takada A, Kida H. Intranasal administration of a synthetic peptide vaccine encapsulated in liposome together with an anti-CD40 antibody induces protective immunity against influenza A virus in mice.
Vaccine   20 3123-3129   2002
Park CH, Ishinaka M, Tkada A, Kida H, Kimura T, Ochiai K, Umemura T. The invasion routes of neuro virulent A/Hong kong/483/97(H5N1) influenza virus into the central nervous system after respiratory infection in mice.
Arch Virol   147 1425-1436   2002
Ko JH, Jin HK, Asano A, Takada A, Ninomiya A, Kida H, HOkiyama H, Ohara M, Tsuzuki M, Nishibori M, Mizutani M, Watanabe T. Polymorphisms and the differential antiviral activity of the chicken Mx gene.
Genome Res   12 595-601   2002
Neumann G, Whitt MA, Kawaoka Y. A Decade After the Generation of a Negative-Sense RNA Virus From Cloned cDNA-What Have We Learned?
J Gen Virol   83, 2635-2662    2002
Shengqing Y, Kishida N, Ito H, Kida H, Otsuki K, Kawaoka Y, Ito T. Generation of Velogenic Newcastle Disease Viruses from a Nonpathogenic Waterfowl Isolate by Passaging in Chickens.
Virology   301, 206-211    2002
Watanabe T, Watanabe S, Kida H, Kawaoka Y. influenza A virus with defective M2 ion channel activity as a live vaccine.
Virology   299, 266-270    2002
Hatta M, Halfmann P, Wells K, Kawaoka Y. Human influenza A viral genes responsible for the restriction of its replication in duck intestine.
Virology   295, 250-255    2002
Ito T, Kobayashi Y, Morita T, Horimoto T, Kawaoka Y. Virulent influenza A viruses induce apoptosis in chickens.
Virus Res   84, 27-35    2002
Watanabe T, Watanabe S, Neumann G, Kida H, Kawaoka Y. Immunogenicity and protective efficacy of replication-incompetent influenza virus-like particles.
J Virol   76, 767-773    2002
Neumann G, Feldamann H, Watanabe S, Lukashevich I, Kawaoka Y. Reverse genetics demonstrates that proteolytic processing of the Ebola virus glycoprotein is not essential for replication in cell culture.
J Virol   76, 406-410    2002
Horimoto T, Kawaoka Y. Pandemic threat posed by avian influenza viruses.
Clin Microbiol Rev. Jan   14(1) 129-149   2001
Virology   287(2) 243-250   2001
Mase M, Imada T, Sanada Y, Etoh M, Sanada Y, Tsukamoto K, Kwaoka Y, Yamaguchi S.Imported parakeets harbor H9N2 influenza A viruses that are genetically closely related to those transmitted to humans in Hong Kong.
J Virol Apr   75(7) 3490-4,   2001
Ito H, Watanabe S, Takada A, Kawaoka Y. Ebola Virus Glycoprotein: Proteolytic Pro Acylation, Cell Tropism, and Detection of Neutralizing Antibodies.
J Virol Feb 1;   75(3), 1576-1580    2001
Hughes MT, McGregor M, Suzuki T, Suzuki Y, Kawaoka Y. Adaptation of influenza A viruses to cells expressing low levels of sialic acid leads to loss of neuraminidase activity.
J Virol Apr;   75(8), 3766-70    2001
Takada A, Watanabe S, Okazaki K, Kida H, Kawaoka Y. Infectivity-enhancing antibodies to Ebola virus glycoprotein.
J Virol Mar;   75(5), 2324-30    2001
Ito T, Goto H, Yamamoto E, Tanaka H, Takeuchi M, Kuwayama M, Kawaoka Y, Otsuki K. Generation of a Highly Pathogenic Avian Influenza A Virus >From an Avirulent Field Isolate by Passaging in Chickens.
J Virol   75, 4439-4443    2001
Goto H, Wells K, Takada A, Kawaoka Y. Plasminogen-binding activity of neuraminidase determines the pathogenicity of influenza A virus.
J Virol   75, 9297-9301    2001
Kobasa D, Wells K, Kawaoka Y. Amino Acids Responsible for the Absolute Sialidase Activity of the Influenza A Virus Neuraminidase: Relationship to Growth in Duck Intestine.
J Virol   75, 11773-11780    2001
Schultz-Cherry S, Dybdahl-Sissoka N, Neymann G, Kawaoka Y, Hinshaw VS. Influenza Virus NS1 Protein Induces Apoptosis in Cultured Cells.
J Virol   75, 7875-7881    2001
Hatta M, Gao P, Halfmann P, Kawaoka Y. Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses.
Science   293, 1840-1842    2001
Horimoto T, Kawaoka Y. Pandemic threat posed by avian influenza viruses.
Clin Microbiol Rev. Jan;   14(1), 129-149    2001
Neumann G, Kawaoka Y. Reverse genetics of influenza virus.
Virology   287(2), 243-250    2001
Clin Microbiol Rev.   14(1) 129-149   2001
Virology   287(2) 243-250   2001
Nichol ST, Arikawa J, Kawaoka Y. Emerging viral diseases.
Proc Natl Acad Sci U S A   97 12411-2   2000
Kawaoka Y. Influenza epidemics in humans, Encyclopedia of Life Sciences
Macmillan      2000
Kawaoka Y. Influenza viruses, Encyclopedia of Life Sciences
Macmillan      2000
Ito T, Kawaoka Y. Host range barrier of influenza A viruses
Vet Microbiol      2000
Neumann G, Kawaoka Y. Genetic engineering of influenza and other negative strand RNA viruses containing segmented genomes
Adv Virus Res      2000
Shortridge KF, Gao P, Guan Y, Ito T, Kawaoka Y, Markwell D, Takada A, Webster RG Interspecies transmission of influenza viruses : H5N1 virus and a hong kong SAR perspective.
Vet Microbiol   74 141-7   2000
Goto H, Kawaoka Y. Assays for functional binding of plasminogen to viral proteins.
Methods   21 159-63   2000
Neumann G, Watanabe T, Kawaoka Y. Plasmid-driven formation of influenza virus-like particles.
J Virol   74 547-51   2000
Hoffmann E, Neumann G, Kawaoka Y, Hobom G, Webster RG. A DNA transfection system for generation of influenza A virus from eight plasmids.
Proc Natl Acad Sci USA      2000
Hatta M, Asano Y, Masunaga K, Ito T, Okazaki K, Toyoda T, Kawaoka Y, Ishihama A, Kida H Eptitope mapping of the influenza A virus RNA polymerase PA using monoclonal antibodies.
Arch Virol   145(5) 957-64   2000
J Virol   74(19) 9300-9305   2000
Ito T, Suzuki Y, Suzuki T, Takada A, Horimoto T, Wells K, Kida H, Otsuki k, Kiso M, Ishida H, Kawaoka Y. Recognition of N-glycolylneuraminic acid linked to galactose by the appha2, 3 linkage is associated with intestinal replication of influenza A...
Neumann G, Watanabe T, Kawaoka Y. Plasmid-driven formation of influenza virus-like particles.
J Virol   74, 547-51    2000
Hoffmann E, Neumann, G, Kawaoka Y, Hobom G, Webster RG. A DNA transfection system for generation of influenza A virus from eight plasmids.
Proc Natl Acad Sci U S A      2000
Mitnaul LJ, Matrosovich MN, Castrucci MR, Tuzikov AB Bovin NV, Kobasa D, Kawaoka Y. Balanced Hemagglutinin and Neuraminidase Activities Are Critical for Efficient Replication of Influenza A Virus.
J Virol   74, 6015-6020    2000
Hatta M, Asano Y, Masunaga K, Ito T, Okazaki K, Toyoda T, Kawaoka Y, Ishihama A, Kida H Epitope mapping of the influenza A virus RNA polyemerase PA using monoclonal antibodies.
Arch Virol   145(5), 957-64    2000
Suzuki Y, Ito T, Suzuki T, Holland Jr, RE, Chambers TM, Kiso M, Ishida H, Kawaoka Y. Sialic acid species as a determinant of the host range of influenza A viruses.
J Virol   74, 11825-31    2000
Chen D, Endres RL, Erickson CA, Weis KF, McGregor MW, Kawaoka Y, Payne LG. Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in mice.
Nature Medicine   6, 1187-1190    2000
Takada A, Watanabe S, Ito H, Okazaki K, Kida H, Kawaoka Y. Downregulation of .1 integrins by Ebola virus glycoprotein: Implication for virus entry.
Virology   278, 20-26    2000
Ito T, Suzuki Y, Suzuki T. Takada A, Horimoto T, Wells K, Kida H, Otsuki K, Kiso M, Ishida H, Kawaoka Y. Recognition of N-glycolylneuraminic acid linked to galactose by the alpha2, 3 linkage is associated with intestinal replication of influenza A viru・・・
J Virol   74(19), 9300-5    2000
Ito T, Suzuki Y, Suzuki T. Takada A, Horimoto T, Wells K, Kida H, Otsuki K, Kiso M, Ishida H, Kawaoka Y. Recognition of N-glycolylneuraminic acid linked to galactose by the alpha2, 3 linkage is associated with intestinal replication of influenza A...
Nichol ST, Arikawa J, Kawaoka Y. Emerging viral diseases.
Proc Natl Acad Sci U S A   97, 12411-2    2000
Kawaoka Y. Influenza epidemics in humans, Encyclopedia of Life Sciences.
Macmillan      2000
Kawaoka Y. Influenza viruses, Encyclopedia of Life Sciences.
Macmillan      2000

Books etc

 
Hughes MT, Matrosovich M, Rodgers ME, McGregor M, Kawaoka Y. Influenza A viruses lacking sialidase activity can undergo multiple cycles of replication in cell culture, eggs, or mice.
J Virol   2000   

Research Grants & Projects

 
Influenza Pathogenesis
Pathogenesis of Ebola virus infection
Development of viral vaccins