KUSUHARA Hiroyuki

J-GLOBAL         Last updated: Oct 15, 2018 at 10:31
 
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Name
KUSUHARA Hiroyuki
E-mail
kusuharamol.f.u-tokyo.ac.jp
Affiliation
The University of Tokyo
Section
Graduate School of Pharmaceutical Sciences, Department of Pharmaceutical Technology
Job title
Associate Professor
Degree
PhD(The University of Tokyo)

Research Areas

 
 

Education

 
Apr 1995
 - 
Mar 1997
Graduate School of Pharmaceutical Sciences, University of Tokyo
 

Awards & Honors

 
2018
Japan Research Foundation for Clinical Pharmacology Award, Japan Research Foundation for Clinical Pharmacology
Winner: Hiroyuki Kusuhara, Kenichi Fujita, Yasutsuna Sasaki
 
2012
Japan Research Foundation for Clinical Pharmacology Award, Japan Research Foundation for Clinical Pharmacology
 

Published Papers

 
Yoshikado T, Toshimoto K, Maeda K, Kusuhara H, Kimoto E, Rodrigues AD, Chiba K, Sugiyama Y
CPT: pharmacometrics & systems pharmacology      Sep 2018   [Refereed]
Sano Y, Mizuno T, Mochizuki T, Uchida Y, Umetsu M, Terasaki T, Kusuhara H
Drug metabolism and disposition: the biological fate of chemicals      Aug 2018   [Refereed]
Izumi S, Nozaki Y, Kusuhara H, Hotta K, Mochizuki T, Komori T, Maeda K, Sugiyama Y
Molecular pharmaceutics   15(6) 2277-2288   Jun 2018   [Refereed]
Takano J, Maeda K, Kusuhara H, Sugiyama Y
Drug metabolism and disposition: the biological fate of chemicals   46(5) 652-657   May 2018   [Refereed]
Imagawa K, Hayashi H, Sabu Y, Tanikawa K, Fujishiro J, Kajikawa D, Wada H, Kudo T, Kage M, Kusuhara H, Sumazaki R
Journal of human genetics   63(5) 569-577   May 2018   [Refereed]
Kaneko K, Tanaka M, Ishii A, Katayama Y, Nakaoka T, Irie S, Kawahata H, Yamanaga T, Wada Y, Miyake T, Toshimoto K, Maeda K, Cui Y, Enomoto M, Kawamura E, Kawada N, Kawabe J, Shiomi S, Kusuhara H, Sugiyama Y, Watanabe Y
Drug metabolism and disposition: the biological fate of chemicals   46(5) 719-728   May 2018   [Refereed]
Takehara I, Yoshikado T, Ishigame K, Mori D, Furihata KI, Watanabe N, Ando O, Maeda K, Sugiyama Y, Kusuhara H
Pharmaceutical research   35(7) 138   May 2018   [Refereed]
Kuwahara H, Song J, Shimoura T, Yoshida-Tanaka K, Mizuno T, Mochizuki T, Zeniya S, Li F, Nishina K, Nagata T, Ito S, Kusuhara H, Yokota T
Scientific reports   8(1) 4377   Mar 2018   [Refereed]
Nakada T, Kudo T, Kume T, Kusuhara H, Ito K
Drug metabolism and pharmacokinetics   33(1) 103-110   Feb 2018   [Refereed]
Hayashi H, Naoi S, Togawa T, Hirose Y, Kondou H, Hasegawa Y, Abukawa D, Sasaki M, Muroya K, Watanabe S, Nakano S, Minowa K, Inui A, Fukuda A, Kasahara M, Nagasaka H, Bessho K, Suzuki M, Kusuhara H
EBioMedicine   27 187-199   Jan 2018   [Refereed]
Kusuhara H, Takashima T, Fujii H, Takashima T, Tanaka M, Ishii A, Tazawa S, Takahashi K, Takahashi K, Tokai H, Yano T, Kataoka M, Inano A, Yoshida S, Hosoya T, Sugiyama Y, Yamashita S, Hojo T, Watanabe Y
Drug metabolism and pharmacokinetics   32(6) 293-300   Dec 2017   [Refereed]
Shimanaka Y, Kono N, Taketomi Y, Arita M, Okayama Y, Tanaka Y, Nishito Y, Mochizuki T, Kusuhara H, Adibekian A, Cravatt BF, Murakami M, Arai H
Nature medicine   23(11) 1287-1297   Nov 2017   [Refereed]
Izumi S, Nozaki Y, Komori T, Takenaka O, Maeda K, Kusuhara H, Sugiyama Y
Journal of pharmaceutical sciences   106(9) 2678-2687   Sep 2017   [Refereed]
Kashihara Y, Ieiri I, Yoshikado T, Maeda K, Fukae M, Kimura M, Hirota T, Matsuki S, Irie S, Izumi N, Kusuhara H, Sugiyama Y
Journal of pharmaceutical sciences   106(9) 2688-2694   Sep 2017   [Refereed]
Kurosawa T, Higuchi K, Okura T, Kobayashi K, Kusuhara H, Deguchi Y
Journal of pharmaceutical sciences   106(9) 2576-2582   Sep 2017   [Refereed]
Kanamitsu K, Kusuhara H, Schuetz JD, Takeuchi K, Sugiyama Y
Journal of pharmaceutical sciences   106(9) 2566-2575   Sep 2017   [Refereed]
Tsuruya Y, Nakanishi T, Komori H, Wang X, Ishiguro N, Kito T, Ikukawa K, Kishimoto W, Ito S, Schaefer O, Ebner T, Yamamura N, Kusuhara H, Tamai I
Journal of pharmaceutical sciences   106(9) 2524-2534   Sep 2017   [Refereed]
Kusuhara H, Obach RS, Rostami-Hodjegan A, Pang KS, Hammarlund-Udenaes M, Derendorf H, Artursson P, Huang SM, Suzuki H, Terasaki T
Journal of pharmaceutical sciences   106(9) 2188-2194   Sep 2017   [Refereed]
Miyake T, Mizuno T, Mochizuki T, Kimura M, Matsuki S, Irie S, Ieiri I, Maeda K, Kusuhara H
Journal of pharmaceutical sciences   106(9) 2542-2550   Sep 2017   [Refereed]
Takano H, Ito S, Zhang X, Ito H, Zhang MR, Suzuki H, Maeda K, Kusuhara H, Suhara T, Sugiyama Y
Journal of pharmaceutical sciences   106(9) 2558-2565   Sep 2017   [Refereed]
Yoshikado T, Maeda K, Furihata S, Terashima H, Nakayama T, Ishigame K, Tsunemoto K, Kusuhara H, Furihata KI, Sugiyama Y
Pharmaceutical research   34(8) 1570-1583   Aug 2017   [Refereed]
Takehara I, Terashima H, Nakayama T, Yoshikado T, Yoshida M, Furihata K, Watanabe N, Maeda K, Ando O, Sugiyama Y, Kusuhara H
Pharmaceutical research   34(8) 1601-1614   Aug 2017   [Refereed]
Yoshikado T, Toshimoto K, Nakada T, Ikejiri K, Kusuhara H, Maeda K, Sugiyama Y
Drug metabolism and disposition: the biological fate of chemicals   45(7) 779-789   Jul 2017   [Refereed]
Shimura S, Watashi K, Fukano K, Peel M, Sluder A, Kawai F, Iwamoto M, Tsukuda S, Takeuchi JS, Miyake T, Sugiyama M, Ogasawara Y, Park SY, Tanaka Y, Kusuhara H, Mizokami M, Sureau C, Wakita T
Journal of hepatology   66(4) 685-692   Apr 2017   [Refereed]
Kanamitsu K, Nozaki Y, Nagaya Y, Sugiyama Y, Kusuhara H
Drug metabolism and pharmacokinetics   32(2) 135-144   Apr 2017   [Refereed]
Watanabe A, Takakusa H, Kimura T, Inoue SI, Kusuhara H, Ando O
Drug metabolism and disposition: the biological fate of chemicals   45(3) 336-341   Mar 2017   [Refereed]
Ito M, Kusuhara H, Ose A, Kondo T, Tanabe K, Nakayama H, Horita S, Fujita T, Sugiyama Y
The AAPS journal   19(1) 286-297   Jan 2017   [Refereed]
Kanamitsu K, Arakawa R, Sugiyama Y, Suhara T, Kusuhara H
Drug metabolism and pharmacokinetics   31(6) 395-404   Dec 2016   [Refereed]
Katsube A, Hayashi H, Kusuhara H
Arteriosclerosis, thrombosis, and vascular biology   36(12) 2304-2314   Dec 2016   [Refereed]
Tsuruya Y, Kato K, Sano Y, Imamura Y, Maeda K, Kumagai Y, Sugiyama Y, Kusuhara H
Drug metabolism and disposition: the biological fate of chemicals   44(12) 1925-1933   Dec 2016   [Refereed]
Kimura H, Yagi Y, Arimitsu K, Maeda K, Ikejiri K, Takano JI, Kusuhara H, Kagawa S, Ono M, Sugiyama Y, Saji H
Journal of labelled compounds & radiopharmaceuticals   59(13) 565-575   Nov 2016   [Refereed]
Kim SJ, Yoshikado T, Ieiri I, Maeda K, Kimura M, Irie S, Kusuhara H, Sugiyama Y
Drug metabolism and disposition: the biological fate of chemicals   44(10) 1622-1632   Oct 2016   [Refereed]
Watanabe A, Takakusa H, Kimura T, Inoue S, Kusuhara H, Ando O
Drug metabolism and disposition: the biological fate of chemicals   44(10) 1608-1616   Oct 2016   [Refereed]
Lechner C, Ishiguro N, Fukuhara A, Shimizu H, Ohtsu N, Takatani M, Nishiyama K, Washio I, Yamamura N, Kusuhara H
Drug metabolism and disposition: the biological fate of chemicals   44(8) 1381-1389   Aug 2016   [Refereed]
Ito S, Hayashi H, Sugiura T, Ito K, Ueda H, Togawa T, Endo T, Tanikawa K, Kage M, Kusuhara H, Saitoh S
Pediatrics international : official journal of the Japan Pediatric Society   58(6) 506-509   Jun 2016   [Refereed]
Hayashi H, Naoi S, Hirose Y, Matsuzaka Y, Tanikawa K, Igarashi K, Nagasaka H, Kage M, Inui A, Kusuhara H
Hepatology research : the official journal of the Japan Society of Hepatology   46(2) 192-200   Feb 2016   [Refereed]
Izumi S, Nozaki Y, Komori T, Takenaka O, Maeda K, Kusuhara H, Sugiyama Y
Molecular pharmaceutics   13(2) 438-448   Feb 2016   [Refereed]
Nagaya Y, Nozaki Y, Takenaka O, Watari R, Kusano K, Yoshimura T, Kusuhara H
Drug metabolism and pharmacokinetics   31(1) 57-66   Feb 2016   [Refereed]
Matsuzaka Y, Hayashi H, Kusuhara H
Molecular pharmacology   88(6) 1085-1092   Dec 2015   [Refereed]
Fujita K, Yoshino E, Kawara K, Maeda K, Kusuhara H, Sugiyama Y, Yokoyama T, Kaneta T, Ishida H, Sasaki Y
Cancer chemotherapy and pharmacology   76(4) 793-801   Oct 2015   [Refereed]
Sakai-Kato K, Nanjo K, Kusuhara H, Nishiyama N, Kataoka K, Kawanishi T, Okuda H, Goda Y
Molecular pharmaceutics   12(9) 3175-3183   Sep 2015   [Refereed]
Shingaki T, Hume WE, Takashima T, Katayama Y, Okauchi T, Hayashinaka E, Wada Y, Cui Y, Kusuhara H, Sugiyama Y, Watanabe Y
Pharmaceutical research   32(8) 2538-2547   Aug 2015   [Refereed]
Kato K, Moriyama C, Ito N, Zhang X, Hachiuma K, Hagima N, Iwata K, Yamaguchi J, Maeda K, Ito K, Suzuki H, Sugiyama Y, Kusuhara H
Pharmaceutical research   32(7) 2192-2204   Jul 2015   [Refereed]
Liu H, Yu N, Lu S, Ito S, Zhang X, Prasad B, He E, Lu X, Li Y, Wang F, Xu H, An G, Unadkat JD, Kusuhara H, Sugiyama Y, Sahi J
Drug metabolism and disposition: the biological fate of chemicals   43(7) 1008-1018   Jul 2015   [Refereed]
Mizuno T, Hayashi H, Kusuhara H
Arteriosclerosis, thrombosis, and vascular biology   35(6) 1347-1356   Jun 2015   [Refereed]
Tomaru A, Takeda-Morishita M, Maeda K, Banba H, Takayama K, Kumagai Y, Kusuhara H, Sugiyama Y
Drug metabolism and pharmacokinetics   30(3) 221-226   Jun 2015   [Refereed]
Izumi S, Nozaki Y, Maeda K, Komori T, Takenaka O, Kusuhara H, Sugiyama Y
Drug metabolism and disposition: the biological fate of chemicals   43(2) 235-247   Feb 2015   [Refereed]
Yagi Y, Kimura H, Arimitsu K, Ono M, Maeda K, Kusuhara H, Kajimoto T, Sugiyama Y, Saji H
Organic & biomolecular chemistry   13(4) 1113-1121   Jan 2015   [Refereed]
Ito N, Ito K, Ikebuchi Y, Kito T, Miyata H, Toyoda Y, Takada T, Hisaka A, Honma M, Oka A, Kusuhara H, Suzuki H
Journal of pharmaceutical sciences   103(10) 3342-3348   Oct 2014   [Refereed]
Akamine Y, Miura M, Komori H, Saito S, Kusuhara H, Tamai I, Ieiri I, Uno T, Yasui-Furukori N
European journal of clinical pharmacology   70(9) 1087-1095   Sep 2014   [Refereed]
Maeda K, Tian Y, Fujita T, Ikeda Y, Kumagai Y, Kondo T, Tanabe K, Nakayama H, Horita S, Kusuhara H, Sugiyama Y
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences   59 94-103   Aug 2014   [Refereed]
Hasegawa Y, Hayashi H, Naoi S, Kondou H, Bessho K, Igarashi K, Hanada K, Nakao K, Kimura T, Konishi A, Nagasaka H, Miyoshi Y, Ozono K, Kusuhara H
Orphanet journal of rare diseases   9 89   Jul 2014   [Refereed]
Kodaira H, Kusuhara H, Fuse E, Ushiki J, Sugiyama Y
Drug metabolism and disposition: the biological fate of chemicals   42(6) 983-989   Jun 2014   [Refereed]
Watashi K, Sluder A, Daito T, Matsunaga S, Ryo A, Nagamori S, Iwamoto M, Nakajima S, Tsukuda S, Borroto-Esoda K, Sugiyama M, Tanaka Y, Kanai Y, Kusuhara H, Mizokami M, Wakita T
Hepatology (Baltimore, Md.)   59(5) 1726-1737   May 2014   [Refereed]
Naoi S, Hayashi H, Inoue T, Tanikawa K, Igarashi K, Nagasaka H, Kage M, Takikawa H, Sugiyama Y, Inui A, Nagai T, Kusuhara H
The Journal of pediatrics   164(5) 1219-1227.e3   May 2014   [Refereed]
Imamura Y, Tsuruya Y, Damme K, Heer D, Kumagai Y, Maeda K, Murayama N, Okudaira N, Kurihara A, Izumi T, Sugiyama Y, Kusuhara H
Drug metabolism and disposition: the biological fate of chemicals   42(4) 685-694   Apr 2014   [Refereed]
Sakai-Kato K, Un K, Nanjo K, Nishiyama N, Kusuhara H, Kataoka K, Kawanishi T, Goda Y, Okuda H
Biomaterials   35(5) 1347-1358   Feb 2014   [Refereed]
Kato K, Mori H, Kito T, Yokochi M, Ito S, Inoue K, Yonezawa A, Katsura T, Kumagai Y, Yuasa H, Moriyama Y, Inui K, Kusuhara H, Sugiyama Y
Pharmaceutical research   31(1) 136-147   Jan 2014   [Refereed]
Iwamoto M, Watashi K, Tsukuda S, Aly HH, Fukasawa M, Fujimoto A, Suzuki R, Aizaki H, Ito T, Koiwai O, Kusuhara H, Wakita T
Biochemical and biophysical research communications   443(3) 808-813   Jan 2014   [Refereed]
Nakada T, Kito T, Inoue K, Masuda S, Inui K, Matsubara K, Moriyama Y, Hisanaga N, Adachi Y, Suzuki M, Yamada I, Kusuhara H
Drug metabolism and pharmacokinetics   29(3) 266-271   2014   [Refereed]
Nagaya Y, Nozaki Y, Kobayashi K, Takenaka O, Nakatani Y, Kusano K, Yoshimura T, Kusuhara H
Drug metabolism and pharmacokinetics   29(5) 419-426   2014   [Refereed]
Kusuhara H
Drug metabolism and pharmacokinetics   29(3) 227-228   2014   [Refereed]
Seki C, Oh-Nishi A, Nagai Y, Minamimoto T, Obayashi S, Higuchi M, Takei M, Furutsuka K, Ito T, Zhang MR, Ito H, Ito M, Ito S, Kusuhara H, Sugiyama Y, Suhara T
EJNMMI research   4 24   2014   [Refereed]
Hume WE, Shingaki T, Takashima T, Hashizume Y, Okauchi T, Katayama Y, Hayashinaka E, Wada Y, Kusuhara H, Sugiyama Y, Watanabe Y
Bioorganic & medicinal chemistry   21(24) 7584-7590   Dec 2013   [Refereed]
Sohda T, Kusuhara H, Egashira Y, Egashira K, Eguchi K, Aoyagi K, Sakisaka S
Clinical journal of gastroenterology   6(6) 424-428   Dec 2013   [Refereed]
Imai S, Kikuchi R, Tsuruya Y, Naoi S, Nishida S, Kusuhara H, Sugiyama Y
Pharmaceutical research   30(11) 2880-2890   Nov 2013   [Refereed]
Izumi S, Nozaki Y, Komori T, Maeda K, Takenaka O, Kusano K, Yoshimura T, Kusuhara H, Sugiyama Y
Drug metabolism and disposition: the biological fate of chemicals   41(10) 1859-1866   Oct 2013   [Refereed]
Shingaki T, Takashima T, Ijuin R, Zhang X, Onoue T, Katayama Y, Okauchi T, Hayashinaka E, Cui Y, Wada Y, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y
The Journal of pharmacology and experimental therapeutics   347(1) 193-202   Oct 2013   [Refereed]
Nakamichi N, Shima H, Asano S, Ishimoto T, Sugiura T, Matsubara K, Kusuhara H, Sugiyama Y, Sai Y, Miyamoto K, Tsuji A, Kato Y
Journal of pharmaceutical sciences   102(9) 3407-3417   Sep 2013   [Refereed]
Ito S, Ando H, Ose A, Kitamura Y, Ando T, Kusuhara H, Sugiyama Y
Journal of pharmaceutical sciences   102(9) 3294-3301   Sep 2013   [Refereed]
Miyajima M, Kusuhara H, Takahashi K, Takashima T, Hosoya T, Watanabe Y, Sugiyama Y
Journal of pharmaceutical sciences   102(9) 3309-3319   Sep 2013   [Refereed]
Toyoshima J, Kusuhara H, Wempe MF, Endou H, Sugiyama Y
Journal of pharmaceutical sciences   102(9) 3228-3238   Sep 2013   [Refereed]
Takahara N, Saga T, Inubushi M, Kusuhara H, Seki C, Ito S, Oyama N, Yokoyama O, Sugiyama Y, Fujibayashi Y
Nuclear medicine and biology   40(5) 643-650   Jul 2013   [Refereed]
Ieiri I, Tsunemitsu S, Maeda K, Ando Y, Izumi N, Kimura M, Yamane N, Okuzono T, Morishita M, Kotani N, Kanda E, Deguchi M, Matsuguma K, Matsuki S, Hirota T, Irie S, Kusuhara H, Sugiyama Y
Journal of clinical pharmacology   53(6) 654-661   Jun 2013   [Refereed]
Imamura Y, Murayama N, Okudaira N, Kurihara A, Inoue K, Yuasa H, Izumi T, Kusuhara H, Sugiyama Y
Pharmaceutical research   30(2) 447-457   Feb 2013   [Refereed]
Takashima T, Wu C, Takashima-Hirano M, Katayama Y, Wada Y, Suzuki M, Kusuhara H, Sugiyama Y, Watanabe Y
Journal of nuclear medicine : official publication, Society of Nuclear Medicine   54(2) 267-276   Feb 2013   [Refereed]
Imai S, Kikuchi R, Kusuhara H, Sugiyama Y
Drug metabolism and disposition: the biological fate of chemicals   41(1) 72-78   Jan 2013   [Refereed]
Kusuhara H, Miura M, Yasui-Furukori N, Yoshida K, Akamine Y, Yokochi M, Fukizawa S, Ikejiri K, Kanamitsu K, Uno T, Sugiyama Y
Drug metabolism and disposition: the biological fate of chemicals   41(1) 206-213   Jan 2013   [Refereed]
Tomaru A, Morimoto N, Morishita M, Takayama K, Fujita T, Maeda K, Kusuhara H, Sugiyama Y
Drug metabolism and pharmacokinetics   28(1) 71-74   2013   [Refereed]
Matsumiya W, Kusuhara S, Hayashibe K, Maruyama K, Kusuhara H, Tagami M, Schuetz JD, Negi A
Investigative ophthalmology & visual science   53(13) 8029-8035   Dec 2012   [Refereed]
Kusuhara H, Furuie H, Inano A, Sunagawa A, Yamada S, Wu C, Fukizawa S, Morimoto N, Ieiri I, Morishita M, Sumita K, Mayahara H, Fujita T, Maeda K, Sugiyama Y
British journal of pharmacology   166(6) 1793-1803   Jul 2012   [Refereed]
Kato K, Kusuhara H, Kumagai Y, Ieiri I, Mori H, Ito S, Nakai Y, Maeda K, Sugiyama Y
Pharmacogenetics and genomics   22(5) 344-354   May 2012   [Refereed]
Takashima T, Kitamura S, Wada Y, Tanaka M, Shigihara Y, Ishii H, Ijuin R, Shiomi S, Nakae T, Watanabe Y, Cui Y, Doi H, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y
Journal of nuclear medicine : official publication, Society of Nuclear Medicine   53(5) 741-748   May 2012   [Refereed]
Jin L, Kikuchi R, Saji T, Kusuhara H, Sugiyama Y
The Journal of pharmacology and experimental therapeutics   340(3) 648-655   Mar 2012   [Refereed]
Ito S, Kusuhara H, Yokochi M, Toyoshima J, Inoue K, Yuasa H, Sugiyama Y
The Journal of pharmacology and experimental therapeutics   340(2) 393-403   Feb 2012   [Refereed]
Wempe MF, Rice PJ, Lightner JW, Jutabha P, Hayashi M, Anzai N, Wakui S, Kusuhara H, Sugiyama Y, Endou H
Drug metabolism and pharmacokinetics   27(1) 155-161   2012   [Refereed]
Okada R, Maeda K, Nishiyama T, Aoyama S, Tozuka Z, Hiratsuka A, Ikeda T, Kusuhara H, Sugiyama Y
Drug metabolism and disposition: the biological fate of chemicals   39(12) 2290-2297   Dec 2011   [Refereed]
Kodaira H, Kusuhara H, Fujita T, Ushiki J, Fuse E, Sugiyama Y
The Journal of pharmacology and experimental therapeutics   339(3) 935-944   Dec 2011   [Refereed]
Wilby AJ, Maeda K, Courtney PF, Debori Y, Webborn PJ, Kitamura Y, Kusuhara H, Riley RJ, Sugiyama Y
Drug metabolism and disposition: the biological fate of chemicals   39(12) 2361-2369   Dec 2011   [Refereed]
Kotani N, Maeda K, Watanabe T, Hiramatsu M, Gong LK, Bi YA, Takezawa T, Kusuhara H, Sugiyama Y
Drug metabolism and disposition: the biological fate of chemicals   39(9) 1503-1510   Sep 2011   [Refereed]
Watanabe T, Kusuhara H, Watanabe T, Debori Y, Maeda K, Kondo T, Nakayama H, Horita S, Ogilvie BW, Parkinson A, Hu Z, Sugiyama Y
Drug metabolism and disposition: the biological fate of chemicals   39(6) 1031-1038   Jun 2011   [Refereed]
Takashima T, Yokoyama C, Mizuma H, Yamanaka H, Wada Y, Onoe K, Nagata H, Tazawa S, Doi H, Takahashi K, Morita M, Kanai M, Shibasaki M, Kusuhara H, Sugiyama Y, Onoe H, Watanabe Y
Journal of nuclear medicine : official publication, Society of Nuclear Medicine   52(6) 950-957   Jun 2011   [Refereed]
Miyajima M, Kusuhara H, Fujishima M, Adachi Y, Sugiyama Y
Drug metabolism and disposition: the biological fate of chemicals   39(5) 814-819   May 2011   [Refereed]
Sugiyama T, Shuto T, Suzuki S, Sato T, Koga T, Suico MA, Kusuhara H, Sugiyama Y, Cyr DM, Kai H
Biochemical and biophysical research communications   404(3) 853-858   Jan 2011   [Refereed]
Watanabe T, Kusuhara H, Sugiyama Y
Journal of pharmacokinetics and pharmacodynamics   37(6) 575-590   Dec 2010   [Refereed]
Takashima T, Nagata H, Nakae T, Cui Y, Wada Y, Kitamura S, Doi H, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y
The Journal of pharmacology and experimental therapeutics   335(2) 314-323   Nov 2010   [Refereed]

Misc

 
Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line
J. Pharmacol. Exp. Ther.   285(3) 1260-1265   1998
Role of transporters in the tissue selective distribution and elimination of drugs : transporters in the liver, kidney and brain
J. Controled Rel.      2001
Drug・drug interactions involving the membrane transportprocess
   2001

Conference Activities & Talks

 
Orthogonal Linear Separation Analysis (OLSA): an Approach to Decompose the Comlex Effects of a Drug to Understand its Pharamacological Properties
Tadahaya Mizuno, Setsuo Kinoshita, Shotaro Maedera, Takuya Ito, and Hiroyuki Kusuhara
CBI学会2018年大会   9 Oct 2018   CBI
Progress in development of endogenous biomarkers to assess transporter-mediated drug-drug interactions
KUSUHARA Hiroyuki
2018 International Meeting on 22nd MDO and 33rd JSSX   4 Oct 2018   JSSX
Identification of N1-methyladenosine as a surrogate biomarker for drug interaction studies involving OCT2
MIYAKE Takeshi, KUSUHARA Hiroyuki
2018 International Meeting on 22nd MDO and 33rd JSSX   3 Oct 2018   JSSX/MDO
Investigation of SLC35F2 drug transport function in mouse brain and primate BBB models
MOCHIZUKI TATSUKI
日本薬物動態学会 第33回年会   2 Oct 2018   日本薬物動態学会
Daiki Mori, Yushi Kashihara, Takashi Yoshikado, Miyuki Kimura, Takeshi Hirota, Shunji Matsuki, Kazuya Maeda, Shin Irie, Ichiro Ieiri, Yuichi Sugiyama, Hiroyuki Kusuhara
2018 International Meeting on 22nd MDO and 33rd JSSX   2 Oct 2018   JSSX
[Purpose]Organic anion transporting polypeptide (OATP) 1B1 is a multispecific organic anion transporter and mediates the hepatic uptake of various anionic drugs. Recently, focusing on OATP1B inhibitors, glycochenodeoxycholate-3-sulfate (GCDCA-S) a...
Development of a Novel Profile Data Analysis Method to Understand Pharmacological Effects: Orthogonal Linear Separation Analysis (OLSA)
Tadahaya Mizuno, Setsuo Kinoshita, Shotaro Maedera, Takuya Ito, and Hiroyuki Kusuhara
2018 International Meeting on 22nd MDO and 33rd JSSX   1 Oct 2018   JSSX
Development of Novel Method to Analyze Transcriptome Profile Data
Tadahaya Mizuno, Setsuo Kinoshita, Takuya Ito, Shotaro Maedera, and Hiroyuki Kusuhara
GPEN2018   29 Sep 2018   GPEN
Investigation of endogenous substrates of OCT2 as surrogate biomarker for the prediction of transporter-mediated drug-drug interaction
MIYAKE Takeshi, KUSUHARA Hiroyuki
Globalization of Pharmaceutics Education Network (GPEN) Conference   28 Sep 2018   GPEN
Elucidation of transporters involved in tissue distribution and urinary excretion of proguanil and cycloguanil in mice
TOMODA yukana
GPEN 2018   27 Sep 2018   The Globalization of Pharmaceutics Education Network (GPEN)
Evaluation of the utility of N1-methyladenosine as a surrogate biomarker for drug interaction studies involving OCT2
MIYAKE Takeshi, KUSUHARA Hiroyuki
Regulatory science forum for young scientists responsible for the next generation   15 Sep 2018   Division of Regulatory Sciences, The Pharmaceutical Society of Japan

Research Grants & Projects

 
Drug transport across the blood brain barrier and blood CSF barrier