2018年12月1日
Repeated photon and C-ion irradiations in vivo have different impact on alteration of tumor characteristics
Scientific Reports
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- 巻
- 8
- 号
- 1
- 開始ページ
- 1458
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/s41598-018-19422-x
- 出版者・発行元
- Nature Publishing Group
Precise characterization of tumor recurrence and regrowth after radiotherapy are important for prognostic understanding of the therapeutic effect. Here, we established a novel in vivo mouse model for evaluating the characteristics of regrown tumor after repeated photon and carbon ion (C-ion) irradiations. The results showed that tumor growth rate, lung metastasis, shortening of the survival of the tumor-bearing mice, and tumor microvessel formation were promoted 2- to 3-fold, and expression of angiogenic and metastatic genes increased 1.5- to 15-fold in regrown tumors after repeated photon irradiations, whereas repeated C-ion irradiations did not alter these characteristics. Interestingly, both repeated photon and C-ion irradiations did not generate radioresistance, which is generally acquired for in vitro treatment. Our results demonstrated that the repetition of photon, and not C-ion, irradiations in vivo alter the characteristics of the regrown tumor, making it more aggressive without acquisition of radioresistance.
- リンク情報
- ID情報
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- DOI : 10.1038/s41598-018-19422-x
- ISSN : 2045-2322
- PubMed ID : 29362374
- SCOPUS ID : 85041000607