2017年2月
Improvement of stability of phenacyloxycarbamidomethyl (Pocam) group, a cysteine protecting group removable with zinc reduction, under acidic conditions
TETRAHEDRON LETTERS
- ,
- 巻
- 58
- 号
- 7
- 開始ページ
- 610
- 終了ページ
- 613
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.tetlet.2016.12.081
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
© 2017 Elsevier Ltd In order to improve the stability of phenacyloxycarbamidomethyl (Pocam) group, a cysteine protecting group removable with zinc reduction, under acidic conditions, various alkyl substituents on the nitrogen atom of Pocam group were examined. As a result, attachment of an electron-withdrawing group improved the stability, and 2,2,2-trifluoroethyl (Tfe) group was most effective among four substituents tested. Tfe-Pocam group could be used in solid-phase peptide synthesis and peptide condensation reactions, and it was also useful for regioselective disulfide formation reactions.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.tetlet.2016.12.081
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000393936800004&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85009493724&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85009493724&origin=inward
- ID情報
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- DOI : 10.1016/j.tetlet.2016.12.081
- ISSN : 0040-4039
- eISSN : 1873-3581
- SCOPUS ID : 85009493724
- Web of Science ID : WOS:000393936800004