2006年8月
Enantioselective synthesis of aurisides A and B, cytotoxic macrolide glycosides of marine origin
TETRAHEDRON
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- 巻
- 62
- 号
- 33
- 開始ページ
- 7687
- 終了ページ
- 7698
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.tet.2006.05.077
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
The enantioselective synthesis of aurisides A and B, macrolide glycosides of marine origin, was achieved by a convergent approach. The C1-C9 segment 4 was prepared from (R)-pantolactone, and the C10-C17 segment 14 was synthesized from (R)-glycidyl trityl ether. The Nozaki-Hiyama-Kishi reaction between 4 and 14 and subsequent reactions gave seco acid 10, which was converted into the aglycon (3) of aurisides by construction of the 14-membered lactone and bromine-substituted conjugated diene. The glycosylation reaction of the aglycon provided aurisides A and B. (c) 2006 Elsevier Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.tet.2006.05.077
- ISSN : 0040-4020
- Web of Science ID : WOS:000239218800007