2020年1月
Formal Total Synthesis of Manzacidin B via Sequential Diastereodivergent Henry Reaction
JOURNAL OF ORGANIC CHEMISTRY
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- 巻
- 85
- 号
- 2
- 開始ページ
- 798
- 終了ページ
- 805
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/acs.joc.9b02811
- 出版者・発行元
- AMER CHEMICAL SOC
A formal total synthesis of manzacidin B is described. beta,beta-Disubstituted gamma-hydroxy-beta-aminoalcohol, the key structure of manzacidin B, is stereoselectively constructed via sequential Henry reactions. By taking advantage of noncovalent interactions, such as intramolecular hydrogen bonding and chelation, we could diastereodivergently control the stereoselectivity of the Henry reaction.
- リンク情報
- ID情報
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- DOI : 10.1021/acs.joc.9b02811
- ISSN : 0022-3263
- eISSN : 1520-6904
- Web of Science ID : WOS:000508468900045