MISC

2000年4月

Differential profiles of nitric oxide and norepinephrine releases in the paraventricular nucleus region in response to mild footshock in rats

BRAIN RESEARCH
  • Y Ishizuka
  • ,
  • Y Ishida
  • ,
  • QH Jin
  • ,
  • K Kato
  • ,
  • T Kunitake
  • ,
  • Y Mitsuyama
  • ,
  • H Kannan

862
1-2
開始ページ
17
終了ページ
25
記述言語
英語
掲載種別
DOI
10.1016/S0006-8993(00)02061-8
出版者・発行元
ELSEVIER SCIENCE BV

The purpose of this study was to determine whether the application of mild intermittent footshock stress can cause changes in the nitric oxide (NO) and norepinephrine (NE) releases in the hypothalamic paraventricular nucleus (PVN) region and medial prefrontal cortex (mPFC). Extracellular levels of NO metabolites and NE in the PVN region and mPFC were determined using an in vivo brain microdialysis technique in conscious rats. In the PVN region, we demonstrated that perfusion of N-methyl-D-aspartate through a microdialysis probe resulted in a dose-dependent increase in NO metabolite levels, whereas intraperitoneal administration of N-G-nitro-L-arginine methyl ester produced a dose-dependent reduction in the levels of NO metabolites. The levels of NO metabolites in the PVN region increased after intraperitoneal administration of interleukin-1 beta in a dose-dependent manner, as we previously reported. This increase in NO metabolite levels was abolished 60 min after systemic administration of NG-nitro-L-arginine methyl ester compared to the vehicle-treated control group. Twenty minutes of intermittent footshock induced NE release but did not induce NO release in the PVN region. On the contrary, in the mPFC, 20 min of intermittent footshock induced both NO and NE releases. The present results reveal different patterns and time courses in NO and NE releases between the PVN region and the mPFC in response to mild intermittent footshock stress. These findings are likely to have helpful suggestions for our understanding of the hypothalamic-pituitary-adrenal axis and the limbic forebrain system response to different kinds of stress. (C) 2000 Elsevier Science B.V. All rights reserved.

Web of Science ® 被引用回数 : 28

リンク情報
DOI
https://doi.org/10.1016/S0006-8993(00)02061-8
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000086656100003&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/S0006-8993(00)02061-8
  • ISSN : 0006-8993
  • Web of Science ID : WOS:000086656100003

エクスポート
BibTeX RIS