論文

査読有り
2015年6月5日

Enhancement of long-term potentiation via muscarinic modulation in the hippocampus of HCNP precursor transgenic mice

Neuroscience Letters
  • Yoshiaki Ohi
  • ,
  • Daisuke Kato
  • ,
  • Masayuki Mizuno
  • ,
  • Toyohiro Sato
  • ,
  • Yoshino Ueki
  • ,
  • Cesario V. Borlongan
  • ,
  • Kosei Ojika
  • ,
  • Akira Haji
  • ,
  • Noriyuki Matsukawa

597
開始ページ
1
終了ページ
6
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.neulet.2015.04.028

© 2015 Elsevier Ireland Ltd. Hippocampal cholinergic neurostimulating peptide (HCNP) regulates acetylcholine synthesis in the septal hippocampus through the quantitative increase of choline acetyltransferase levels in the septal nucleus both in vitro and in vivo. Additionally, HCNP-precursor protein transgenic (HCNP-pp Tg) mice display depressive behavior. To examine the physiological function of HCNP and/or HCNP-pp on hippocampal neural activity, we investigated whether overexpression of HCNP-pp strengthened the efficiency of neural activity in the hippocampus. Long-term potentiation (LTP) of excitatory synaptic transmission was induced by a tetanic stimulation of the Schaffer collateral-commissural fibers (SCs) in mouse hippocampal slices. LTP in HCNP-pp Tg mice was significantly enhanced when compared with wild-type littermate (WT) mice. This facilitation of LTP in HCNP-pp Tg mice was blocked by atropine or pirenzepine, but not by mecamylamine. In contrast, LTP in WT mice was not affected by atropine, but enhanced by carbachol. However, neither difference in the input-output relationship of field excitatory postsynaptic potentials nor in the facilitation ratio in paired-pulse stimulation of the SCs was observed between HCNP-pp Tg and WT mice, indicating that presynaptic glutamate release in HCNP-pp Tg mice is similar to that of WT mice. These results suggest that muscarinic (M1) modulation of glutamatergic postsynaptic function may be involved in strengthening LTP in HCNP-pp Tg mice.

リンク情報
DOI
https://doi.org/10.1016/j.neulet.2015.04.028
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25899776
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84928137634&origin=inward
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84928137634&origin=inward
ID情報
  • DOI : 10.1016/j.neulet.2015.04.028
  • ISSN : 0304-3940
  • eISSN : 1872-7972
  • PubMed ID : 25899776
  • SCOPUS ID : 84928137634

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