2009年9月
Synthesis of Sominone and Its Derivatives Based on an RCM Strategy: Discovery of A Novel Anti-Alzheimer's Disease Medicine Candidate "Denosomin"
ORGANIC LETTERS
- ,
- ,
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- 巻
- 11
- 号
- 17
- 開始ページ
- 3970
- 終了ページ
- 3973
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1021/ol901553w
- 出版者・発行元
- AMER CHEMICAL SOC
Synthesis of sominone was achieved starting from dehydroepiandrosterone on the basis of an RCM strategy for the construction of a delta-lactone side chain. This synthetic protocol was applied for the synthesis of several analogous derivatives including 1-deoxy-24-norsominone (denosomin), which was revealed to exhibit notable bioactivities for new antidementia chemotherapy, exceeding the original natural compound sominone.
- リンク情報
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- DOI
- https://doi.org/10.1021/ol901553w
- CiNii Articles
- http://ci.nii.ac.jp/naid/80020600791
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/19653648
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000269252900046&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1021/ol901553w
- ISSN : 1523-7060
- CiNii Articles ID : 80020600791
- PubMed ID : 19653648
- Web of Science ID : WOS:000269252900046