2016年3月
Linezolid-resistant Staphylococcus epidermidis associated with long-term, repeated linezolid use in a pediatric patient
JOURNAL OF INFECTION AND CHEMOTHERAPY
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- 巻
- 22
- 号
- 3
- 開始ページ
- 187
- 終了ページ
- 190
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.jiac.2015.10.004
- 出版者・発行元
- ELSEVIER SCIENCE BV
We report an 8-year-old patient with catheter-related bacteremia caused by linezolid-resistant Staphylococcus epidermidis that was isolated after the long-term, repeated use of linezolid. Three S. epidermidis strains isolated from this patient were bacteriologically analyzed. While the strain isolated prior to linezolid initiation was susceptible to linezolid, two strains after linezolid therapy displayed low-level linezolid susceptibility (MIC, 4 mg/L) and linezolid resistance (MIC, 16 mg/L). T2500A mutation in two copies and G2575T mutations in three copies of 23S rRNA were detected in the low-susceptible strain and the resistant strain, respectively. Linezolid-resistant S. epidermidis infection is rare, but may occur with the long-term administration of linezolid. (C) 2015, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.jiac.2015.10.004
- ISSN : 1341-321X
- eISSN : 1437-7780
- PubMed ID : 26603427
- Web of Science ID : WOS:000372543400012