Sep, 2014
Penicillin-Susceptible Group B Streptococcal Clinical Isolates with Reduced Cephalosporin Susceptibility
JOURNAL OF CLINICAL MICROBIOLOGY
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- Volume
- 52
- Number
- 9
- First page
- 3406
- Last page
- 3410
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1128/JCM.01291-14
- Publisher
- AMER SOC MICROBIOLOGY
We characterized penicillin-susceptible group B streptococcal (PSGBS) clinical isolates exhibiting no growth inhibition zone around a ceftibuten disk (CTBr PSGBS). The CTBr PSGBS isolates, for which augmented MICs of cefaclor and ceftizoxime were found, shared a T394A substitution in penicillin-binding protein 2X (PBP 2X) and a T567I substitution in PBP 2B, together with an additional G429S substitution in PBP 2X or a T145A substitution in PBP 1A, although the T145A substitution in the transglycosidase domain of PBP 1A would have no effect on the level of resistance to ceftibuten.
- Link information
- ID information
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- DOI : 10.1128/JCM.01291-14
- ISSN : 0095-1137
- eISSN : 1098-660X
- Pubmed ID : 24920773
- Web of Science ID : WOS:000341359300041