Biomaterials Center is composed of five groups and collaborate each other to examine interdisciplinary fields of biomaterials. In the ceramics-based biomaterials research, we have been developing three novel bone regeneration materials, i.e., high-porosity hydroxyapatite (HAp) ceramics with high-strength, guided bone regeneration (GBR) membranes and bone-like nanocomposite composed of HAp and collagen. The GBR membrane composed of beta-tricalcium phosphate and biodegradable copolymer of lactide, glycolide and epsilon-caprolactone has thermoplastic, pH auto-adjustment and enough mechanical property to protect an invasion of surrounding tissues. With the membrane, bone defect up to 20 x 10 x 10 mm(3) in length in mandibles and segmental bone defect Lip to 20 mm in length in tibiae of beagles are regenerated without any additional bone fillers or cell transplantations. The bone-like nanocomposite is synthesized by a co-precipitation of HAp and collagen via their self-organization. The dense composite has a half to quarter mechanical strength (40 MPa) to cortical bone and the porous one demonstrates sponge-like viscoelasticity. The composites implanted into bone are incorporated into bone remode ing metabolism like as autogenous bone graft, i.e., they are resorbed by osteolasts followed by osteogenesis by osteoblasts.