1996年
Vertical Transmission to Embryo and Fetus in Maternal Infection with Rat Virus (RV)
Experimental Animals
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- 巻
- 45
- 号
- 3
- 開始ページ
- 239
- 終了ページ
- 244
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1538/expanim.45.239
- 出版者・発行元
- International Press Editing Centre Incorporation
The influence of maternal rat virus (RV) infection on rat embryogenesis and fetus was examined by viral reisolation, immunostaining and PCR analysis. Vertical transmission caused by the UT-1 strain of RV depended on the stage of gestation when maternal infection occurred. When females were infected at the pre-mating point, the number of fetuses was smaller than that normally obtained, possibly due to infection at the stage of the hatched blastocyst, but almost all of the fetuses obtained were free from infection and developed normally. The incidence of transplacental infection was the highest when pregnant females were infected in the middle of the gestation stage, and some of the fetuses died. In pregnant females which were infected late in the gestation stage, all fetuses developed normally. Some of them were infected transplacentally and harbored the infectious virus. Much attention should be paid to performing reliable rederivation of RV-infected rat colonies by hysterectomy and embryo transfer.
- ID情報
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- DOI : 10.1538/expanim.45.239
- ISSN : 1341-1357
- PubMed ID : 8840140
- SCOPUS ID : 0030184707