2012年11月
A pediatric patient with myopathy associated with antibodies to a signal recognition particle
BRAIN & DEVELOPMENT
- 巻
- 34
- 号
- 10
- 開始ページ
- 877
- 終了ページ
- 880
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.braindev.2012.02.009
- 出版者・発行元
- ELSEVIER SCIENCE BV
We report the case of a 15-year-old Japanese girl with myopathy associated with antibodies to a signal recognition particle (anti-SRP myopathy). The patient presented with progressive symmetrical proximal muscle weakness that caused difficulty in walking within 3 months, and marked elevation of the serum creatine kinase levels. A skeletal muscle biopsy revealed active necrotic and regenerating processes, with mild inflammatory changes. Based on the above findings, the patient was diagnosed as having anti-SRP myopathy. Only a limited number of pediatric patients with anti-SRP myopathy has been reported previously, with usually a poor prognosis. Early diagnosis is important for obtaining a better prognosis in patients with anti-SRP myopathy. (C) 2012 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.braindev.2012.02.009
- ISSN : 0387-7604
- PubMed ID : 22436377
- Web of Science ID : WOS:000311466000016