YOSHIYAMA Hironori

J-GLOBAL         Last updated: Sep 16, 2019 at 10:16
 
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Name
YOSHIYAMA Hironori
Affiliation
Shimane University
Section
Faculty of Medicine, School of Medicine

Research Areas

 
 

Awards & Honors

 
Apr 1996
Chemotaxis of Helicobacter pylori toward urea is independent of urease, Basic Science Award
 

Published Papers

 
Yanagi A, Nishikawa J, Shimokuri K, Shuto T, Takagi T, Takagi F, Kobayashi Y, Yamamoto M, Miura O, Yanai H, Suehiro Y, Yamasaki T, Yoshiyama H, Sakaida I.
Microorganisms   7(9) 305-305   Sep 2019   [Refereed]
Liu G, Ma X, Wang Z, Wakae K, Yuan Y, He Z, Yoshiyama H, Iizasa H, Zhang H, Matsuda M, Sugiyama R, Yuan Z, Muramatsu M, Li L
The Journal of biological chemistry      Jul 2019   [Refereed]
Yanai H, Iizasa H, Chihara D, Murakami T, Nishikawa J, Yoshiyama H
Endoscopy international open   7(4) E431-E432   Apr 2019   [Refereed]
Ichikawa T, Okuno Y, Sato Y, Goshima F, Yoshiyama H, Kanda T, Kimura H, Murata T
mSphere   3(6)    Nov 2018   [Refereed]
Sasaki S, Nishikawa J, Sakai K, Iizasa H, Yoshiyama H, Yanagihara M, Shuto T, Shimokuri K, Kanda T, Suehiro Y, Yamasaki T, Sakaida I
Gastric cancer   21    Sep 2018   [Refereed]
Nishikawa J, Iizasa H, Yoshiyama H, Shimokuri K, Kobayashi Y, Sasaki S, Nakamura M, Yanai H, Sakai K, Suehiro Y, Yamasaki T, Sakaida I
Cancers   10(6) 167   May 2018   [Refereed]
【ヘルペスウイルス感染症の最近の知見】 ヘルペスウイルス感染症の動向
金廣 優一, 上野 詩織, 吉山 裕規
臨牀と研究   95(4) 329-333   Apr 2018
Kanehiro Y, Tomioka H, Pieters J, Tatano Y, Kim H, Iizasa H, Yoshiyama H
Frontiers in microbiology   9(9) 1517   2018   [Refereed]
Nanbo A, Ohashi M, Yoshiyama H, Ohba Y
Frontiers in microbiology   9(9) 984   2018   [Refereed]
Yu F, Lu Y, Tao L, Jiang YY, Lin DC, Wang L, Petersson F, Yoshiyama H, Koeffler PH, Goh BC, Loh KS
Scientific reports   7(1) 17359   Dec 2017   [Refereed]
Epstein-Barrウイルス関連がんとRNA/DNA編集酵素
金廣 優一, 飯笹 久, 吉山 裕規
細胞   49(8) 405-407   Jul 2017
Epstein-Barrウイルス(EBV)は、リンパ球や上皮細胞などに長期間持続感染することによって様々な腫瘍を形成する。EBVは少数の霊長類以外には感染しないため動物モデルを用いた研究が進まず、特に、EBV関連上皮細胞腫の発がん分子機構の解明は遅れていた。それに対して、薬剤選択マーカーを組み込んだ組換えEBVを用いた上皮細胞感染モデルの研究が進められた。その結果、ウイルスの感染に抵抗して宿主細胞が発現するRNA/DNA編集酵素などは、早期には抗ウイルス因子として働くが、持続的に作用するこ...
Nishikawa J, Iizasa H, Yoshiyama H, Nakamura M, Saito M, Sasaki S, Shimokuri K, Yanagihara M, Sakai K, Suehiro Y, Yamasaki T, Sakaida I
International journal of molecular sciences   18(8) 1606   Jul 2017   [Refereed]
【古くて新しい日和見感染症】 ウイルス感染症 EBウイルス感染症
金廣 優一, 飯笹 久, 吉山 裕規
臨床と微生物   44(1) 069-076   Jan 2017
Epstein-Barrウイルス(EBV)は、成人のほとんどが感染している普遍的なウイルスであるが、一方で腫瘍ウイルスでもある。本稿では、EBVの発見された経緯、基本的な特徴、感染様式、関与する疾患などについて概説した後、EBVのマイクロRNAや次世代シークエンス技術がもたらしたEBVゲノム研究などの最新の知見についても解説する。(著者抄録)
Kim H, Iizasa H, Kanehiro Y, Fekadu S, Yoshiyama H
Frontiers in microbiology   8 1318   2017   [Refereed]
Torii Y, Kawada JI, Murata T, Yoshiyama H, Kimura H, Ito Y
PloS one   12(4) e0175053   2017   [Refereed]
Nanbo A, Kachi K, Yoshiyama H, Ohba Y
The Journal of general virology   97(11) 2989-3006   Nov 2016   [Refereed]
Murata T, Noda C, Narita Y, Watanabe T, Yoshida M, Ashio K, Sato Y, Goshima F, Kanda T, Yoshiyama H, Tsurumi T, Kimura H
Journal of virology   90(8) 3873-3889   Apr 2016   [Refereed]
Iizasa H, Ishihara S, Richardo T, Kanehiro Y, Yoshiyama H
World journal of gastroenterology   21(40) 11450-11457   Oct 2015   [Refereed]
Nishikawa J, Yoshiyama H, Iizasa H, Kanehiro Y, Nakamura M, Nishimura J, Saito M, Okamoto T, Sakai K, Suehiro Y, Yamasaki T, Oga A, Yanai H, Sakaida I
Cancers   6(4) 2259-2274   Nov 2014   [Refereed]
Purification and Fluorescent Labelling of Exosomes.
Nanbo A, Kawanishi E, Yoshida R, Yoshiyama H.
Bio-protocols   4(7) e1103   Apr 2014   [Refereed]
Baghdadi M, Yoneda A, Yamashina T, Nagao H, Komohara Y, Nagai S, Akiba H, Foretz M, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Takeya M, Viollet B, Yagita H, Jinushi M.
Immunity   39(6) 1070-1081   Dec 2013   [Refereed]
Jinushi M, Yagita H, Yoshiyama H, Tahara H
Trends in Molecular Medicine   19(9) 536-545   Sep 2013   [Refereed]
Nanbo A, Kawanishi E, Yoshida R, Yoshiyama H
Journal of Virology   87(18) 3420-3439   Jun 2013   [Refereed]
Baghdadi M, Nagao H, Yoshiyama H, Akiba H, Yagita H, Dosaka-Akita H, Jinushi M
Cancer Immunology and Immunotherapy   62(4) 629-637   Apr 2013   [Refereed]
Iizasa H, Nanbo A, Nishikawa J, Jinushi M, Yoshiyama H
Viruses   4(12) 3420-3439   Dec 2012   [Refereed]
Chiba S, Baghdadi M, Akiba H, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Fujioka Y, Ohba Y, Gorman JV, Colgan JD, Hirashima M, Uede T, Takaoka A, Yagita H, Jinushi M
Nature Immunology   13(9) 832-842   Sep 2012   [Refereed]
Jinushi M, Chiba S, Baghdadi M, Kinoshita I, Dosaka-Akita H, Yoshiyama H, Yagita H, Uede T, Takaoka A.
Cancer Research   72(1) 56-65   Jan 2012   [Refereed]
Regulation of cancer stem cell activities by tumor-associated macrophages.
Jinushi M, Baghdadi M, Chiba S, Yoshiyama H
American Journal of Cancer Research   2(5) 529-539   2012   [Refereed]
Kanda T, Shibata S, Saitou S, Murata T, Isomura H, Yoshiyama H, Takada K, Tsurumi T.
PLoS ONE   6(11) e27758   Nov 2011   [Refereed]
Jinushi M, Chiba S, Yoshiyama H, Masutomi K, Kinoshita I, Dosaka-Akita H, Yagita H, Takaoka A, Tahara H
Proc Natl Acad Sci USA   108(30) 12425-12430   Jul 2011   [Refereed]
Miyauchi K, Urano E, Yoshiyama H, Komano J
Cancer Science   102(6) 1236-1241   Jun 2011   [Refereed]
Kariya Y, Hamatake M, Urano E, Yoshiyama H, Shimizu N, Komano J.
Cancer Science   101(4) 876-881   Apr 2010   [Refereed]
[Infection and mechanism of proliferation in herpes virus].
Yoshiyama H
Nihon rinsho. Japanese journal of clinical medicine   64 Suppl 3 43-48   Mar 2006   [Refereed]
Okamoto T, Yoshiyama H, Nakazawa T, Park ID, Chang MW, Yanai H, Okita K, Shirai M
The Journal of antimicrobial chemotherapy   50(6) 849-856   Dec 2002   [Refereed]
Igarashi M, Kitada Y, Yoshiyama H, Takagi A, Miwa T, Koga Y
Infection and Immunity   69 816-821   2001
Yoshiyama H, Nakazawa T
Microbes and Infection   2(1) 55-60   2000   [Refereed]

Misc

 
消化性潰瘍は感染症か Helicobacter pyloriと消化性潰瘍疾患 H. pyloriとは 菌の性状など細菌学的知識
吉山 裕規, 中澤 晶子
臨床と微生物   24(3) 247-254   May 1997
AIDSの臨床とその病態 初感染,HIV変異そして発症
吉山 裕規, 高田 賢蔵
最新医学   50(3) 381-389   Mar 1995
神経細胞とAIDS
吉山 裕規
組織培養   20(4) 144-148   Apr 1994
ICLは新しい疾患概念か? Idiopathic CD4+ T-lymphocytopenia
吉山 裕規, 小林 信之
内科   72(5) 948-950   Nov 1993
ヒト免疫不全ウイルス(HIV)の分離(2)
吉山 裕規, 山本 直樹
組織培養   15(9) 292-294   Aug 1989

Books etc

 
Helicobacter meets inflammatory bowel disease.
Nakazawa T, Akada JT, Yoshiyama H, Takeuchi H, Fujinaga R, Shirai M (Part:Joint Work, Molecular mechanism of persistant infection of Helicobacter pylori in gastric mucosa.)
Medical Tribune Inc.   2002   
Gann Monograph on Cancer Research No. 45; Epstein-Barr virus and human cancer.
Yanai H, Shimizu N, Mizugaki Y, Nishikawa J, Yoshiyama H, Tada M, Okita K, Takada K (Part:Joint Work, The gastric mucosa surrounding Epstein-Barr virus-associated gastric cancers.)
Japanese Cancer Association   1998   
Viral Quantitation in HIV Infection
Ho DD, Yoshiyama H, Mohri H, Daar ES, Cao Y (Part:Joint Work, Quantitation on of HIV-1 : significance in pathogenesis and therapy.)
John Libbey Eurotext   1991   
《Cent Gardes》 1991; Retroviruses of Human A.I.D.S. and Related Animal Diseases.
Ho DD, Fung MSC, Yoshiyama H, Cao Y, Robinson JE (Part:Joint Work, Discontinuous epitopes on gp120 important in HIV-1 neutralization.)
Foundation Marcel Mérieux   1991   

Conference Activities & Talks

 
Epstein-Barr virus promotes stemness of oral squamous cell carcinoma.
Chukkris Heawchaiyaphum, Tipaya Ekalaksananan, Hisashi Iizasa, Yuichi Kanehiro, Tohru Kiyono, Hironori Yoshiyama, Chamsai Pientong
22nd European Society for Clinical Virology's Annual Meeting   11 Sep 2019   
Oncogenic properties of Epstein-Barr virus in epithelial infections [Invited]
YOSHIYAMA Hironori
Development of Collaboration Meeting   7 Aug 2019   
Regulation of EBV encoded BART miRNA by viral LMP 2A through host cell transcriptional activators.
Kim H, Iizasa H, Kanehiro Y, Yoshiyama H.
The 44th Anuual International Herpesvirus Workshop   20 Jul 2019   
Transcriptional activation of Epstein-Barr virus encoded BART miRNAs in NK/T lymphomas
YOSHIYAMA Hironori
28 Oct 2018   
Biological properties of Epstein-Barr virus positive oral squamous cell carcinoma cell lines
Chukkris Heawchaiyaphum, Tipaya Ekalaksananan, Hisashi Iizasa, Yuichi Kanehiro, Tohru Kiyono, Hironori Yoshiyama, Chamsai Pientong
27 Sep 2018   
LMP2A regulates BART miRNAs transcription by translational activation of ETS family genes
Kim H, Iizasa H, Kanehiro Y, Yoshiyama H
2018 International Conference on EBV and KSHV   28 Jul 2018   
Research on preventive vaccine for Epstein-Barr virus infected oropharyngeal cancers showing regional accumulation
16 Jun 2018   
Epstein-Barr virus infection of epithelial cells causes mitochondrial DNA mutation through induction of APOBEC3C [Invited]
Kanehiro Y, Kim H, Fekadu S, Iizasa H, Yoshiyama H
The 19th Royal Golden Jubilee Ph.D. Congress   8 Jun 2018   
Epstein-Barr virus infection of epithelial cells induces APOBEC3C and generates mitochondrial DNA mutation
Yoshiyama H, Kanehiro Y, Kim H, Sintayehu F, Iizasa H
Viruses 2018 - Breakthroughs in Viral Replication   7 Feb 2018   
Epstein-Barr viral BART miRNA transcription is upregulated by LMP2A via host transcription factors in epithelial cells
Hyoji Kim, Hisashi Iizasa, Yuichi Kanehiro, Timmy Richardo, Hironori Yoshiyama
24 Oct 2017   

Association Memberships

 
 

Research Grants & Projects

 
Research in Infection-associated Cancer
Project Year: 2008   
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2005 - 2006    Investigator(s): Kenzo TAKADA
1.Research in EBV Receptor in Epithelial CellEpstein-Barr Virus (EBV) infects both B lymphocytes and epithelial cells. EBV uses CD21 as a receptor and gp350 as a viral ligand for its adsorption to B lymphocytes. However, epithelial cell dose not o...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1999 - 2001    Investigator(s): Hironori YOSHIYAMA
EB virus (EBV) causes Burkitt's lymphoma and nasopharyngeal carcinoma, though EBV is a ubiquitous human herpes virus that infects greater than 90 % of the world's population. Cofactors or risk factors has been considered to be important for the cl...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 1996 - 1997    Investigator(s): Teruko NAKAZAWA
Urease of Helicobacter pylori is essential for colonization and responsible for gastric epithelial injury.(1) We analyzed the transcripts of urease operons and found that ureIE,one of the ccessory operons for urease activation, is induced under ac...
Development of Virus Vector

Others

 
Jan 2013
Editor : American Journal of Infectious Diseases and Microbiology