SIOMI Haruhiko

J-GLOBAL         Last updated: Sep 3, 2019 at 09:56
 
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Name
SIOMI Haruhiko
Affiliation
Keio University
Section
School of Medicine
Job title
Professor
Degree
Doctor of Medical Science

Research Areas

 
 

Academic & Professional Experience

 
Feb 2008
 - 
Today
Professor, School of Medicine, Keio University
 
1988
 - 
1990
: Research fellow of the Japan Society for the
 
 
   
 
Promotion of Science for Japanese Junior Scientists
 
1990
 - 
1997
: Research Associate, University of Pennsylvania
 
 
   
 
School of Medicine
 

Education

 
 
   
 
Kyoto University
 
 
   
 
Gifu University
 

Awards & Honors

 
 
1989: Tonen Fundamental Research Prize
 
 
1998: MRDDRC Young Investigator Award
 
 
1999: FRAXA Research Foundation Award
 
 
2000: CAN Foundation Research Award
 

Published Papers

 
Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation
Yamanaka S, Nishihara H, Toh H, Nagai LAE, Hashimoto K, Park SJ, Shibuya A, Suzuki AM, Tanaka Y, Nakai K, Carninci P, Sasaki H, Siomi H.
Developmental Cell   DOI 10.1016/j.devcel.2019.07.0    Aug 2019   [Refereed]
Zhang C, Seo J, Murakami K, Salem ESB, Bernhard E, Borra VJ, Choi K, Yuan CL, Chan CC, Chen X, Huang T, Weirauch MT, Divanovic S, Qi NR, Thomas HE, Mercer CA, Siomi H, Nakamura T
Nature communications   9(1) 3658   Sep 2018   [Refereed]
Yashiro R, Murota Y, Nishida KM, Yamashiro H, Fujii K, Ogai A, Yamanaka S, Negishi L, Siomi H, Siomi MC
Cell reports   23(12) 3647-3657   Jun 2018   [Refereed]
Hasuwa H, Ishino K, Siomi H
Science China. Life sciences   61(3) 348-350   Mar 2018   [Refereed]
Nishida KM, Sakakibara K, Iwasaki YW, Yamada H, Murakami R, Murota Y, Kawamura T, Kodama T, Siomi H, Siomi MC
Nature   555(7695) 260-264   Mar 2018   [Refereed]
Murano K, Iwasaki YW, Siomi H
Methods in molecular biology (Clifton, N.J.)   1680 165-177   2018   [Refereed]
Iwasaki YW, Ishino K, Siomi H
Methods (San Diego, Calif.)   126 66-75   Aug 2017   [Refereed]
Hasuwa H, Siomi H
Science (New York, N.Y.)   355(6325) 581-582   Feb 2017   [Refereed]
Hirano T, Hasuwa H, Siomi H
Methods in molecular biology (Clifton, N.J.)   1463 205-216   2017   [Refereed]
Matsumoto N, Nishimasu H, Sakakibara K, Nishida KM, Hirano T, Ishitani R, Siomi H, Siomi MC, Nureki O
Cell   167(2) 484-497.e9   Oct 2016   [Refereed]
Iwasaki YW, Murano K, Ishizu H, Shibuya A, Iyoda Y, Siomi MC, Siomi H, Saito K
Molecular cell   63(3) 408-419   Aug 2016   [Refereed]
Sumiyoshi T, Sato K, Yamamoto H, Iwasaki YW, Siomi H, Siomi MC
Genes & development   30(14) 1617-1622   Jul 2016   [Refereed]
Shibata N, Kashima M, Ishiko T, Nishimura O, Rouhana L, Misaki K, Yonemura S, Saito K, Siomi H, Siomi MC, Agata K
Developmental cell   37(3) 226-237   May 2016   [Refereed]
Lin ZY, Hikabe O, Suzuki S, Hirano T, Siomi H, Sasaki E, Imamura M, Okano H
Primates; journal of primatology   57(1) 129-135   Jan 2016   [Refereed]
Yamanaka S, Siomi H
The EMBO journal   34(24) 2988-2989   Dec 2015   [Refereed]
Parrish NF, Fujino K, Shiromoto Y, Iwasaki YW, Ha H, Xing J, Makino A, Kuramochi-Miyagawa S, Nakano T, Siomi H, Honda T, Tomonaga K
RNA (New York, N.Y.)   21(10) 1691-1703   Oct 2015   [Refereed]
Sato K, Iwasaki YW, Shibuya A, Carninci P, Tsuchizawa Y, Ishizu H, Siomi MC, Siomi H
Molecular cell   59(4) 553-563   Aug 2015   [Refereed]
Ishizu H, Iwasaki YW, Hirakata S, Ozaki H, Iwasaki W, Siomi H, Siomi MC
Cell reports   12(3) 429-440   Jul 2015   [Refereed]
Siomi H, Siomi MC
Science (New York, N.Y.)   348(6236) 756-757   May 2015   [Refereed]
Lin ZY, Hirano T, Shibata S, Seki NM, Kitajima R, Sedohara A, Siomi MC, Sasaki E, Siomi H, Imamura M, Okano H
Developmental biology   400(1) 43-58   Apr 2015   [Refereed]
Matsumoto N, Sato K, Nishimasu H, Namba Y, Miyakubi K, Dohmae N, Ishitani R, Siomi H, Siomi MC, Nureki O
Cell reports   11(3) 366-375   Apr 2015   [Refereed]
Hirano T, Siomi H
Current biology : CB   25(7) R280-3   Mar 2015   [Refereed]
Nishida KM, Iwasaki YW, Murota Y, Nagao A, Mannen T, Kato Y, Siomi H, Siomi MC
Cell reports   10(2) 193-203   Jan 2015   [Refereed]
Iwasaki YW, Siomi MC, Siomi H
Annual review of biochemistry   84 405-433   2015   [Refereed]
Sato K, Iwasaki YW, Siomi H, Siomi MC
Fly   9(2) 86-90   2015   [Refereed]
Iwasaki YW, Siomi H
Molecular cell   56(5) 615-616   Dec 2014   [Refereed]
Hirano T, Iwasaki YW, Lin ZY, Imamura M, Seki NM, Sasaki E, Saito K, Okano H, Siomi MC, Siomi H
RNA (New York, N.Y.)   20(8) 1223-1237   Aug 2014   [Refereed]
Murota Y, Ishizu H, Nakagawa S, Iwasaki YW, Shibata S, Kamatani MK, Saito K, Okano H, Siomi H, Siomi MC
Cell reports   8(1) 103-113   Jul 2014   [Refereed]
Siomi H
EMBO reports   15(6) 620-621   Jun 2014   [Refereed]
Yamanaka S, Siomi H
Cell research   24(5) 511-512   May 2014   [Refereed]
Yamanaka S, Siomi MC, Siomi H
Mobile DNA   5 22   2014   [Refereed]
Ohtani H, Iwasaki YW, Shibuya A, Siomi H, Siomi MC, Saito K
Genes & development   27(15) 1656-1661   Aug 2013   [Refereed]
Nishida KM, Miyoshi K, Ogino A, Miyoshi T, Siomi H, Siomi MC
Molecular cell   49(4) 680-691   Feb 2013   [Refereed]
Miyoshi K, Ogino A, Siomi MC, Siomi H
Methods in molecular biology (Clifton, N.J.)   1010 111-121   2013   [Refereed]
Nishimasu H, Ishizu H, Saito K, Fukuhara S, Kamatani MK, Bonnefond L, Matsumoto N, Nishizawa T, Nakanaga K, Aoki J, Ishitani R, Siomi H, Siomi MC, Nureki O
Nature   491(7423) 284-287   Nov 2012   [Refereed]
Ishizu H, Siomi H, Siomi MC
Genes & development   26(21) 2361-2373   Nov 2012   [Refereed]
Cernilogar FM, Onorati MC, Kothe GO, Burroughs AM, Parsi KM, Breiling A, Lo Sardo F, Saxena A, Miyoshi K, Siomi H, Siomi MC, Carninci P, Gilmour DS, Corona DF, Orlando V
Nature   480(7377) 391-395   Nov 2011   [Refereed]
Sato K, Nishida KM, Shibuya A, Siomi MC, Siomi H
Genes & development   25(22) 2361-2373   Nov 2011   [Refereed]
Ishizu H, Nagao A, Siomi H
Current opinion in genetics & development   21(4) 484-490   Aug 2011   [Refereed]
Siomi H, Siomi MC
Cell   145(7) 1005-1007   Jun 2011   [Refereed]
Miyoshi K, Okada TN, Siomi H, Siomi MC
Methods in molecular biology (Clifton, N.J.)   725 29-43   2011   [Refereed]
Nagao A, Sato K, Nishida KM, Siomi H, Siomi MC
Frontiers in genetics   2 55   2011   [Refereed]
Nagao A, Mituyama T, Huang H, Chen D, Siomi MC, Siomi H
RNA (New York, N.Y.)   16(12) 2503-2515   Dec 2010   [Refereed]
Hain D, Bettencourt BR, Okamura K, Csorba T, Meyer W, Jin Z, Biggerstaff J, Siomi H, Hutvagner G, Lai EC, Welte M, Müller HA
PloS one   5(12) e15264   Dec 2010   [Refereed]
Saito K, Ishizu H, Komai M, Kotani H, Kawamura Y, Nishida KM, Siomi H, Siomi MC
Genes & development   24(22) 2493-2498   Nov 2010   [Refereed]
Siomi MC, Miyoshi T, Siomi H
Seminars in cell & developmental biology   21(7) 754-759   Sep 2010   [Refereed]
Miyoshi K, Miyoshi T, Siomi H
Molecular genetics and genomics : MGG   284(2) 95-103   Aug 2010   [Refereed]
Miyoshi T, Takeuchi A, Siomi H, Siomi MC
Nature structural & molecular biology   17(8) 1024-1026   Aug 2010   [Refereed]
Siomi H, Siomi MC
Molecular cell   38(3) 323-332   May 2010   [Refereed]
Siomi MC, Mannen T, Siomi H
Genes & development   24(7) 636-646   Apr 2010   [Refereed]
Miyoshi K, Miyoshi T, Hartig JV, Siomi H, Siomi MC
RNA (New York, N.Y.)   16(3) 506-515   Mar 2010   [Refereed]
Otsuka S, Sakamoto Y, Siomi H, Itakura M, Yamamoto K, Matumoto H, Sasaki T, Kato N, Nanba E
Brain & development   32(2) 110-114   Feb 2010   [Refereed]
Sato K, Siomi H
Genome biology   11(3) 109   2010   [Refereed]
Inose H, Ochi H, Kimura A, Fujita K, Xu R, Sato S, Iwasaki M, Sunamura S, Takeuchi Y, Fukumoto S, Saito K, Nakamura T, Siomi H, Ito H, Arai Y, Shinomiya K, Takeda S
Proceedings of the National Academy of Sciences of the United States of America   106(49) 20794-20799   Dec 2009   [Refereed]
Nishida KM, Okada TN, Kawamura T, Mituyama T, Kawamura Y, Inagaki S, Huang H, Chen D, Kodama T, Siomi H, Siomi MC
The EMBO journal   28(24) 3820-3831   Dec 2009   [Refereed]
Saito K, Inagaki S, Mituyama T, Kawamura Y, Ono Y, Sakota E, Kotani H, Asai K, Siomi H, Siomi MC
Nature   461(7268) 1296-1299   Oct 2009   [Refereed]
Siomi H, Siomi MC
Nature cell biology   11(9) 1049-1051   Sep 2009   [Refereed]
Miyoshi K, Okada TN, Siomi H, Siomi MC
RNA (New York, N.Y.)   15(7) 1282-1291   Jul 2009   [Refereed]
Qian ZR, Asa SL, Siomi H, Siomi MC, Yoshimoto K, Yamada S, Wang EL, Rahman MM, Inoue H, Itakura M, Kudo E, Sano T
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc   22(3) 431-441   Mar 2009   [Refereed]
Siomi H, Siomi MC
Nature   457(7228) 396-404   Jan 2009   [Refereed]
[Non-coding RNAs: where we are and where we are heading].
Siomi H
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   53(15) 1926-1931   Dec 2008   [Refereed]
Siomi MC, Saito K, Siomi H
FEBS letters   582(17) 2473-2478   Jul 2008   [Refereed]
Kawamura Y, Saito K, Kin T, Ono Y, Asai K, Sunohara T, Okada TN, Siomi MC, Siomi H
Nature   453(7196) 793-797   Jun 2008   [Refereed]
Azuma-Mukai A, Oguri H, Mituyama T, Qian ZR, Asai K, Siomi H, Siomi MC
Proceedings of the National Academy of Sciences of the United States of America   105(23) 7964-7969   Jun 2008   [Refereed]
Sekine T, Yamaguchi T, Hamano K, Siomi H, Saez L, Ishida N, Shimoda M
Zoological science   25(6) 561-571   Jun 2008   [Refereed]
Siomi H, Siomi MC
Current opinion in genetics & development   18(2) 181-187   Apr 2008   [Refereed]
Miyoshi K, Uejima H, Nagami-Okada T, Siomi H, Siomi MC
Methods in molecular biology (Clifton, N.J.)   442 29-43   2008   [Refereed]
Siomi MC, Siomi H
Nucleic acids symposium series (2004)   (52) 59-60   2008   [Refereed]
Siomi MC, Nishida KM, Siomi H
Methods in enzymology   449 345-355   2008   [Refereed]
Nishida KM, Saito K, Mori T, Kawamura Y, Nagami-Okada T, Inagaki S, Siomi H, Siomi MC
RNA (New York, N.Y.)   13(11) 1911-1922   Nov 2007   [Refereed]
Saito K, Sakaguchi Y, Suzuki T, Suzuki T, Siomi H, Siomi MC
Genes & development   21(13) 1603-1608   Jul 2007   [Refereed]
Siomi H, Siomi MC
Genes & development   21(10) 1153-1156   May 2007   [Refereed]
Gunawardane LS, Saito K, Nishida KM, Miyoshi K, Kawamura Y, Nagami T, Siomi H, Siomi MC
Science (New York, N.Y.)   315(5818) 1587-1590   Mar 2007   [Refereed]
Saito K, Nishida KM, Mori T, Kawamura Y, Miyoshi K, Nagami T, Siomi H, Siomi MC
Genes & development   20(16) 2214-2222   Aug 2006   [Refereed]
Ishizuka A, Saito K, Siomi MC, Siomi H
Methods in molecular biology (Clifton, N.J.)   342 277-286   2006   [Refereed]
Miyoshi K, Tsukumo H, Nagami T, Siomi H, Siomi MC
Genes & development   19(23) 2837-2848   Dec 2005   [Refereed]
Saito K, Ishizuka A, Siomi H, Siomi MC
PLoS biology   3(7) e235   Jul 2005   [Refereed]
Siomi MC, Tsukumo H, Ishizuka A, Nagami T, Siomi H
RNA (New York, N.Y.)   11(7) 1004-1011   Jul 2005   [Refereed]
Siomi MC, Siomi H
Methods in molecular biology (Clifton, N.J.)   309 1-9   2005   [Refereed]
Okamura K, Ishizuka A, Siomi H, Siomi MC
Genes & development   18(14) 1655-1666   Jul 2004   [Refereed]
Siomi H, Ishizuka A, Siomi MC
Mental retardation and developmental disabilities research reviews   10(1) 68-74   2004   [Refereed]
Siomi MC, Higashijima K, Ishizuka A, Siomi H
Molecular and cellular biology   22(24) 8438-8447   Dec 2002   [Refereed]
Ishizuka A, Siomi MC, Siomi H
Genes & development   16(19) 2497-2508   Oct 2002   [Refereed]
Inoue S, Shimoda M, Nishinokubi I, Siomi MC, Okamura M, Nakamura A, Kobayashi S, Ishida N, Siomi H
Current biology : CB   12(15) 1331-1335   Aug 2002   [Refereed]
Tabara H, Yigit E, Siomi H, Mello CC
Cell   109(7) 861-871   Jun 2002   [Refereed]
Molecular mechanisms of fragile X syndrome.
Inoue SB, Siomi MC, Siomi H
The journal of medical investigation : JMI   47(3-4) 101-107   Aug 2000   [Refereed]
Astrocyte-specific expression of human T-cell lymphotropic virus type 1 (HTLV-1) Tax: induction of tumor necrosis factor alpha and susceptibility to lysis by CD8+ HTLV-1-specific cytotoxic T cells.
Méndez E, Kawanishi T, Clemens K, Siomi H, Soldan SS, Calabresi P, Brady J, Jacobson S
Journal of virology   71(12) 9143-9149   Dec 1997   [Refereed]
Nakielny S, Siomi MC, Siomi H, Michael WM, Pollard V, Dreyfuss G
Experimental cell research   229(2) 261-266   Dec 1996   [Refereed]
Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them.
Siomi MC, Zhang Y, Siomi H, Dreyfuss G
Molecular and cellular biology   16(7) 3825-3832   Jul 1996   [Refereed]
Cis/trans-activation of the interleukin-9 receptor gene in an HTLV-I-transformed human lymphocytic cell.
Kubota S, Siomi H, Hatanaka M, Pomerantz RJ
Oncogene   12(7) 1441-1447   Apr 1996   [Refereed]
Molecular characterization of the protein products of the fragile X syndrome gene and the survival of motor neurons gene.
Liu Q, Siomi H, Siomi MC, Fischer U, Zhang Y, Wan L, Dreyfuss G
Cold Spring Harbor symposia on quantitative biology   61 689-697   1996   [Refereed]
Kubota S, Furuta RA, Siomi H, Maki M, Hatanaka M
FEBS letters   375(1-2) 31-36   Nov 1995   [Refereed]
FXR1, an autosomal homolog of the fragile X mental retardation gene.
Siomi MC, Siomi H, Sauer WH, Srinivasan S, Nussbaum RL, Dreyfuss G
The EMBO journal   14(11) 2401-2408   Jun 1995   [Refereed]
Iwakura Y, Tosu M, Yoshida E, Saijo S, Nakayama-Yamada J, Itagaki K, Asano M, Siomi H, Hatanaka M, Takeda T
Virus genes   9(2) 161-170   Jan 1995   [Refereed]
Signal sequences that target nuclear import and nuclear export of pre-mRNA-binding proteins.
Michael WM, Siomi H, Choi M, Piñol-Roma S, Nakielny S, Liu Q, Dreyfuss G
Cold Spring Harbor symposia on quantitative biology   60 663-668   1995   [Refereed]
A cellular protein which is coprecipitated with HTLV-I rex protein in the presence of the target mRNA.
Katahira J, Siomi H, Ishizaki T, Umemoto T, Tanaka Y, Shida H
Oncogene   9(12) 3535-3544   Dec 1994   [Refereed]
Long cellular repeats flanking a defective HTLV-I provirus: implication for site-targeted integration.
Kubota S, Furuta R, Maki M, Siomi H, Hatanaka M
Oncogene   8(10) 2873-2877   Oct 1993   [Refereed]
Siomi H, Matunis MJ, Michael WM, Dreyfuss G
Nucleic acids research   21(5) 1193-1198   Mar 1993   [Refereed]
Functional comparison of transactivation by human retrovirus rev and rex genes.
Sakai H, Siomi H, Shida H, Shibata R, Kiyomasu T, Adachi A
Journal of virology   64(12) 5833-5839   Dec 1990   [Refereed]
HTLV-1 p27rex stabilizes human interleukin-2 receptor alpha chain mRNA.
Kanamori H, Suzuki N, Siomi H, Nosaka T, Sato A, Sabe H, Hatanaka M, Honjo T
The EMBO journal   9(12) 4161-4166   Dec 1990   [Refereed]

Misc

 
J. Cell Biol. 129:551-560. 1995   
Essential role for KH domains in RNA binding: impaired RNA binding by a mutation in the KH domain of FMR-1 that causes fragile X syndrome.
Cell 76:33-39. 1994   
Curr. Opin. Genet.. Dev. 7:345-353. 1997   

Research Grants & Projects

 
Program for Totipotency
MEXT: MEXT Grant-in-Aid for Scientific Research on Innovative Areas
Project Year: Jul 2019 - Mar 2024    Investigator(s): SIOMI Haruhiko
AMED: Project for Elucidating and Controlling Mechanisms of Aging and Longevity
Project Year: 2017 - 2021    Investigator(s): SIOMI Haruhiko
Cell biological approach to understanding functions of RNA-binding proteins