Toshiyuki Obata - My portal - researchmap

Profile Information

Affiliation: Professor, Former Institution / Organization Shiga University of Medical Science Undergraduate School of Medicine Faculty of Medicine
: 副診療部長, 赤穂市民病院

Degree: MD. Ph D

J-GLOBAL ID: 200901019678966518
researchmap Member ID: 5000002218

Research Interests

2

Research History

5

Education

4

Committee Memberships

2

Awards

6

Misc.

51

ERK1/2 activation by angiotensin II inhibits insulin-induced glucose uptake in vascular smooth muscle cells

Y Izawa, M Yoshizumi, Y Fujita, N Ali, Y Kanematsu, K Ishizawa, K Tsuchiya, T Obata, Y Ebina, S Tomita …

EXPERIMENTAL CELL RESEARCH, 308(2) 291-299, Aug, 2005
Functional Analysis of PIK3CA Gene Mutations in Human Colorectal Cancer.

Cancer Res, 65(11):4562-7., 2005
Inhibition of Akt kinase activity by a peptide spanning the beta A strand of the proto-oncogene TCL1

M Hiromura, F Okada, T Obata, D Auguin, T Shibata, C Roumestand, M Noguchi

JOURNAL OF BIOLOGICAL CHEMISTRY, 279(51) 53407-53418, Dec, 2004
Ugi, S. et al. Protein Phosphatase 2A Negatively Regulates Insulin's Metabolic Signaling Pathway by Inhibiting Akt (Protein Kinase B) Activity in 3T3-L1 Adipocytes.

Mol Cell Biol, 24, 8778-8789, 2004
Nogami, S. et al. ZFH-4 protein is expressed in many neurons of developing rat brain.

Journal of Comparative Neurology, 2004
Kanezaki, Y. et al. K(ATP) Channel Knockout Mice Crossbred with Transgenic Mice Expressing a Dominant-negative Form of Human Insulin Receptor Have Glucose Intolerance but not Diabetes.

Endocr J, 51, 133-44, 2004
Yuasa, T. et al. Platelet-derived growth factor stimulates glucose transport in skeletal muscles of transgenic mice specifically expressing PDGF receptor in the muscle, but does not affect the blood glucose levels.

Diabetes, 53(11):2776-86., 2004
The PI-3 Kinase Pathway Regulates Bladder Cancer Cell Invasion.

BJU Int, 93(1):143-50., 2004
Ugi, S. et al. Protein Phosphatase 2A Negatively Regulates Insulin's Metabolic Signaling Pathway by Inhibiting Akt (Protein Kinase B) Activity in 3T3-L1 Adipocytes.

Mol Cell Biol, 24, 8778-8789, 2004
Nogami, S. et al. ZFH-4 protein is expressed in many neurons of developing rat brain.

Journal of Comparative Neurology, 2004
Kanezaki, Y. et al. K(ATP) Channel Knockout Mice Crossbred with Transgenic Mice Expressing a Dominant-negative Form of Human Insulin Receptor Have Glucose Intolerance but not Diabetes.

Endocr J, 51, 133-44, 2004
Yuasa, T. et al. Platelet-derived growth factor stimulates glucose transport in skeletal muscles of transgenic mice specifically expressing PDGF receptor in the muscle, but does not affect the blood glucose levels.

Diabetes, 2004
Injection of the insulin receptor alpha subunit increases blood glucose levels in mice

Y Kanezaki, R Matsushima, T Obata, Y Nakaya, T Matsumoto, Y Ebina

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 309(3) 572-577, Sep, 2003
Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions

T Katome, T Obata, R Matsushima, N Masuyama, LC Cantley, Y Gotoh, K Kishi, H Shiota, Y Ebina

JOURNAL OF BIOLOGICAL CHEMISTRY, 278(30) 28312-28323, Jul, 2003
Increased Insulin Sensitivity and Hypoinsulinemia in APS Knockout Mice.

Diabetes, 52:2657-2665., 2003
Differential regulation of Akt kinase isoforms by the members of TCL1 oncogene family

J Laine, G Kunstle, T Obata, M Noguchi

JOURNAL OF BIOLOGICAL CHEMISTRY, 277(5) 3743-3751, Feb, 2002
Ogawara, Y., Kishishita, S., Obata, T., Isazawa, Y., Suzuki, T., Tanaka, K., Masuyama, N., and Gotoh, Y., Akt enhances Mdm2-mediated ubiquitination and degradation of p53.

J Biol Chem, 277, 21843-21850, 2002
Laine, J., Kunstle, S., Obata, T., and Noguchi, M., Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family.

J Biol Chem, 277, 3743-3751, 2002
Egawa, K., Maegawa, H., Shi, K., Nakamura, T., Obata, T., Yoshizaki, T., Morino, K., Shimizu, S., Nishino, Y., Suzuki, E., and Kashiwagi, A., Membrance Localozation of 3-Phoshoinositide-dependent Protein Kinase-1 Stimulates Activities of Akt and Atypic・・・

J Biol Chem, 277, 38863-38869, 2002
Ogawara, Y., Kishishita, S., Obata, T., Isazawa, Y., Suzuki, T., Tanaka, K., Masuyama, N., and Gotoh, Y., Akt enhances Mdm2-mediated ubiquitination and degradation of p53.

J Biol Chem, 277, 21843-21850, 2002

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