小畑利之 (Toshiyuki Obata) - マイポータル - researchmap

基本情報

所属: 旧所属滋賀医科大学医学部医学科
: 赤穂市民病院副診療部長

学位: 医学博士(滋賀医科大学・医学研究科（日本）)

J-GLOBAL ID: 200901019678966518
researchmap会員ID: 5000002218

研究キーワード

2

経歴

5

学歴

4

- 1998年

滋賀医科大学医学部博士課程
- 1998年

Graduate School of Siga University of Medical Science
滋賀医科大学医学部
Siga University of Medical Science

委員歴

2

受賞

6

MISC

51

ERK1/2 activation by angiotensin II inhibits insulin-induced glucose uptake in vascular smooth muscle cells

Y Izawa, M Yoshizumi, Y Fujita, N Ali, Y Kanematsu, K Ishizawa, K Tsuchiya, T Obata, Y Ebina, S Tomita …

EXPERIMENTAL CELL RESEARCH 308(2) 291-299 2005年8月
Functional Analysis of PIK3CA Gene Mutations in Human Colorectal Cancer.

Cancer Res 65(11):4562-7. 2005年
Inhibition of Akt kinase activity by a peptide spanning the beta A strand of the proto-oncogene TCL1

M Hiromura, F Okada, T Obata, D Auguin, T Shibata, C Roumestand, M Noguchi

JOURNAL OF BIOLOGICAL CHEMISTRY 279(51) 53407-53418 2004年12月
Ugi, S. et al. Protein Phosphatase 2A Negatively Regulates Insulin's Metabolic Signaling Pathway by Inhibiting Akt (Protein Kinase B) Activity in 3T3-L1 Adipocytes.

Mol Cell Biol 24, 8778-8789 2004年
Nogami, S. et al. ZFH-4 protein is expressed in many neurons of developing rat brain.

Journal of Comparative Neurology 2004年
Kanezaki, Y. et al. K(ATP) Channel Knockout Mice Crossbred with Transgenic Mice Expressing a Dominant-negative Form of Human Insulin Receptor Have Glucose Intolerance but not Diabetes.

Endocr J 51, 133-44 2004年
Yuasa, T. et al. Platelet-derived growth factor stimulates glucose transport in skeletal muscles of transgenic mice specifically expressing PDGF receptor in the muscle, but does not affect the blood glucose levels.

Diabetes 53(11):2776-86. 2004年
The PI-3 Kinase Pathway Regulates Bladder Cancer Cell Invasion.

BJU Int 93(1):143-50. 2004年
Ugi, S. et al. Protein Phosphatase 2A Negatively Regulates Insulin's Metabolic Signaling Pathway by Inhibiting Akt (Protein Kinase B) Activity in 3T3-L1 Adipocytes.

Mol Cell Biol 24, 8778-8789 2004年
Nogami, S. et al. ZFH-4 protein is expressed in many neurons of developing rat brain.

Journal of Comparative Neurology 2004年
Kanezaki, Y. et al. K(ATP) Channel Knockout Mice Crossbred with Transgenic Mice Expressing a Dominant-negative Form of Human Insulin Receptor Have Glucose Intolerance but not Diabetes.

Endocr J 51, 133-44 2004年
Yuasa, T. et al. Platelet-derived growth factor stimulates glucose transport in skeletal muscles of transgenic mice specifically expressing PDGF receptor in the muscle, but does not affect the blood glucose levels.

Diabetes 2004年
Injection of the insulin receptor alpha subunit increases blood glucose levels in mice

Y Kanezaki, R Matsushima, T Obata, Y Nakaya, T Matsumoto, Y Ebina

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 309(3) 572-577 2003年9月
Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions

T Katome, T Obata, R Matsushima, N Masuyama, LC Cantley, Y Gotoh, K Kishi, H Shiota, Y Ebina

JOURNAL OF BIOLOGICAL CHEMISTRY 278(30) 28312-28323 2003年7月
Increased Insulin Sensitivity and Hypoinsulinemia in APS Knockout Mice.

Diabetes 52:2657-2665. 2003年
Differential regulation of Akt kinase isoforms by the members of TCL1 oncogene family

J Laine, G Kunstle, T Obata, M Noguchi

JOURNAL OF BIOLOGICAL CHEMISTRY 277(5) 3743-3751 2002年2月
Ogawara, Y., Kishishita, S., Obata, T., Isazawa, Y., Suzuki, T., Tanaka, K., Masuyama, N., and Gotoh, Y., Akt enhances Mdm2-mediated ubiquitination and degradation of p53.

J Biol Chem 277, 21843-21850 2002年
Laine, J., Kunstle, S., Obata, T., and Noguchi, M., Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family.

J Biol Chem 277, 3743-3751 2002年
Egawa, K., Maegawa, H., Shi, K., Nakamura, T., Obata, T., Yoshizaki, T., Morino, K., Shimizu, S., Nishino, Y., Suzuki, E., and Kashiwagi, A., Membrance Localozation of 3-Phoshoinositide-dependent Protein Kinase-1 Stimulates Activities of Akt and Atypic・・・

J Biol Chem 277, 38863-38869 2002年
Ogawara, Y., Kishishita, S., Obata, T., Isazawa, Y., Suzuki, T., Tanaka, K., Masuyama, N., and Gotoh, Y., Akt enhances Mdm2-mediated ubiquitination and degradation of p53.

J Biol Chem 277, 21843-21850 2002年

もっとみる

所属学協会

5

共同研究・競争的資金等の研究課題

2