Shingo Dan - My portal

Profile Information

Affiliation: Chief, Cancer Chemotherapy Center Division of Molecular Pharmacology, Japanese Foundation for Cancer Research

Degree: Ph.D.

J-GLOBAL ID: 200901075222725427
researchmap Member ID: 5000002741

External link: https://www.jfcr.or.jp/chemotherapy/department/molecular_pharmacology/index.html

Research Interests

Research Areas

Research History

Nov, 2017 - Present

Japanese Foundation for Cancer Research
Jul, 2012 - Oct, 2017

Japanese Foundation for Cancer Research
Dec, 2010 - Jun, 2012

主任研究員, 癌化学療法センター分子薬理部, 財団法人癌研究会
Apr, 2000 - Nov, 2010

研究員, 癌化学療法センター分子薬理部, 財団法人癌研究会
Apr, 1999 - Mar, 2000

Institute of Molecular and Cellular Biosciences, The University of Tokyo
2000

: Research associate at Cancer Chemotherapy Center,
1999

: Post-doctoral researcher at Institute of Molecular &
Japanese Foundation for Cancer Research
Cellular Bioscience, University of Tokyo

Education

Apr, 1994 - Mar, 1999

生命薬学専攻, 薬学系研究科, 東京大学大学院
- 1999

Graduate School, Division of Pharmaceutical Sciences, The University of Tokyo
Apr, 1990 - Mar, 1994

Department of Pharmacy, Faculty of Pharmaceutical Sciences, The University of Tokyo
- 1994

Faculty of Pharmaceutical Science, The University of Tokyo

Committee Memberships

2018 - Present

広報委員, 日本癌学会
2016 - Present

Executive Member (general), がん研究会国際がん化学療法シンポジウム
2012 - Present

評議員, 日本癌学会
2009 - Present

選挙管理委員, 日本がん分子標的治療学会
2009 - Present

事務局総務幹事, 日本がん分子標的治療学会
2009 - Present

評議員, 日本がん分子標的治療学会

Awards

Papers

High-throughput screening in colorectal cancer tissue-originated spheroids.

Jumpei Kondo, Tomoya Ekawa, Hiroko Endo, Kanami Yamazaki, Norio Tanaka, Yoji Kukita, Hiroaki Okuyama, Jiro Okami, Fumio Imamura, Masayuki Ohue …

Cancer science, 110(1) 345-355, Jan, 2019 Peer-reviewed
Antitumor profile of the PI3K inhibitor ZSTK474 in human sarcoma cell lines.

Nachi Namatame, Naomi Tamaki, Yuya Yoshizawa, Mutsumi Okamura, Yumiko Nishimura, Kanami Yamazaki, Miwa Tanaka, Takuro Nakamura, Kentaro Semba, Takao Yamori …

Oncotarget, 9(80) 35141-35161, Oct 12, 2018 Peer-reviewed
Target Identification of Yaku'amide B and Its Two Distinct Activities against Mitochondrial F_oF₁-ATP Synthase.

Kitamura K, Itoh H, Sakurai K, Dan S, Inoue M

Journal of the American Chemical Society, 140(38) 12189-12199, Sep, 2018 Peer-reviewed
Synthesis and Biological Activities of Acetal Analogs at Position 3 of 10-Methyl-Aplog-1, A Potential Anti-Cancer Lead Derived from Debromoaplysiatoxin.

Hayakawa K, Hanaki Y, Tokuda H, Yanagita RC, Nagahara Y, Okamura M, Dan S, Irie K

Heterocycles, 97, Apr, 2018 Peer-reviewed
Targeting the Golgi apparatus to overcome acquired resistance of non-small cell lung cancer cells to EGFR tyrosine kinase inhibitors.

Yoshimi Ohashi, Mutsumi Okamura, Ryohei Katayama, Siyang Fang, Saki Tsutsui, Akinobu Akatsuka, Mingde Shan, Hyeong-Wook Choi, Naoya Fujita, Kentaro Yoshimatsu …

Oncotarget, 9(2) 1641-1655, Jan 5, 2018 Peer-reviewed
TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling.

Natsumi Kawasaki, Kazunobu Isogaya, Shingo Dan, Takao Yamori, Hiroshi Takano, Ryoji Yao, Yasuyuki Morishita, Luna Taguchi, Masato Morikawa, Carl-Henrik Heldin …

Cell discovery, 4 1-1, 2018 Peer-reviewed
Family-wide Analysis of the Inhibition of Arf Guanine Nucleotide Exchange Factors with Small Molecules: Evidence of Unique Inhibitory Profiles

Sarah Benabdi, Francois Peurois, Agata Nawrotek, Jahnavi Chikireddy, Tatiana Caneque, Takao Yamori, Isamu Shiina, Yoshimi Ohashi, Shingo Dan, Raphael Rodriguez …

BIOCHEMISTRY, 56(38) 5125-5133, Sep, 2017 Peer-reviewed
Convergent synthesis of stereoisomers of THF ring moiety of acetogenin thiophene analogue and their antiproliferative activities against human cancer cell lines

Takuya Matsumoto, Naoto Kojima, Akinobu Akatsuka, Takao Yamori, Shingo Dan, Hiroki Iwasaki, Masayuki Yamashita

TETRAHEDRON, 73(17) 2359-2366, Apr, 2017 Peer-reviewed
Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities

Yusuke Hanaki, Masayuki Kikumori, Harukuni Tokuda, Mutsumi Okamura, Shingo Dan, Naoko Adachi, Naoaki Saito, Ryo C. Yanagita, Kazuhiro Irie

MOLECULES, 22(4), Apr, 2017 Peer-reviewed
Total Synthesis of the Depsipeptide FR901375 and Preliminary Evaluation of Its Biological Activity

Koichi Narita, Yuya Katoh, Ken-ichi Ojima, Singo Dan, Takao Yamori, Akihiro Ito, Minoru Yoshida, Tadashi Katoh

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 34(34) 5667-5677, Dec, 2016 Peer-reviewed
Synthesis and biological evaluation of novel FK228 analogues as potential isoform selective HDAC inhibitors

Koichi Narita, Keisuke Matsuhara, Jun Itoh, Yui Akiyama, Singo Dan, Takao Yamori, Akihiro Ito, Minoru Yoshida, Tadashi Katoh

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 121 592-609, Oct, 2016 Peer-reviewed
M-COPA, a novel Golgi system disruptor, suppresses apoptosis induced by Shiga toxin

Takayuki Hattori, Miho Watanabe-Takahashi, Isamu Shiina, Yoshimi Ohashi, Shingo Dan, Kiyotaka Nishikawa, Takao Yamori, Mikihiko Naito

GENES TO CELLS, 21(8) 901-906, Aug, 2016 Peer-reviewed
A novel thiophene-3-carboxamide analog of annonaceous acetogenin exhibits antitumor activity via inhibition of mitochondrial complex I

Akinobu Akatsuka, Naoto Kojima, Mutsumi Okamura, Shingo Dan, Takao Yamori

Pharmacology Research and Perspectives, 4(4) e00246, Aug 1, 2016 Peer-reviewed
M-COPA, a Golgi Disruptor, Inhibits Cell Surface Expression of MET Protein and Exhibits Antitumor Activity against MET-Addicted Gastric Cancers

Yoshimi Ohashi, Mutsumi Okamura, Asaka Hirosawa, Naomi Tamaki, Akinobu Akatsuka, Kuo-Ming Wu, Hyeong-Wook Choi, Kentaro Yoshimatsu, Isamu Shiina, Takao Yamori …

CANCER RESEARCH, 76(13) 3895-3903, Jul, 2016 Peer-reviewed
Serum VEGF-A and CCL5 levels as candidate biomarkers for efficacy and toxicity of regorafenib in patients with metastatic colorectal cancer

Mitsukuni Suenaga, Tetsuo Mashima, Naomi Kawata, Takeru Wakatsuki, Yuki Horiike, Satoshi Matsusaka, Shingo Dan, Eiji Shinozaki, Hiroyuki Seimiya, Nobuyuki Mizunuma …

ONCOTARGET, 7(23) 34811-34823, Jun, 2016 Peer-reviewed
Synthesis and in vitro cancer cell growth inhibition evaluation of 11-amino-modified 5-Me-indolo[2,3-b]quinolines and their COMPARE analyses

Masashi Okada, Zhen-Wu Mei, Md. Imran Hossain, Li Wang, Taihei Tominaga, Takeshi Takebayashi, Masaharu Murakami, Mizuki Yasuda, Tsukasa Shigehiro, Tomonari Kasai …

MEDICINAL CHEMISTRY RESEARCH, 25(5) 879-892, May, 2016 Peer-reviewed
Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription

Yasushi Takemoto, Akihiro Ito, Hideaki Niwa, Mutsumi Okamura, Takashi Fujiwara, Tomoya Hirano, Noriko Handa, Takashi Umehara, Takeshi Sonoda, Kenji Ogawa …

JOURNAL OF MEDICINAL CHEMISTRY, 59(8) 3650-3660, Apr, 2016 Peer-reviewed
Pyrrocidine A, a metabolite of endophytic fungi, has a potent apoptosis-inducing activity against HL60 cells through caspase activation via the Michael addition

Shota Uesugi, Nozomi Fujisawa, Jun Yoshida, Mitsuru Watanabe, Shingo Dan, Takao Yamori, Yoshihito Shiono, Ken-ichi Kimura

JOURNAL OF ANTIBIOTICS, 69(3) 133-140, Mar, 2016 Peer-reviewed
Identification of a molecular target of kurahyne, an apoptosis-inducing lipopeptide from marine cyanobacterial assemblages

Arihiro Iwasaki, Osamu Ohno, Shun Katsuyama, Maho Morita, Yukiko Sasazawa, Shingo Dan, Siro Simizu, Takao Yamori, Kiyotake Suenaga

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25(22) 5295-5298, Nov, 2015 Peer-reviewed
Ridaifen G, tamoxifen analog, is a potent anticancer drug working through a combinatorial association with multiple cellular factors

Kentaro Ikeda, Shinji Kamisuki, Shoko Uetake, Akihito Mizusawa, Nozomi Ota, Tatsuki Sasaki, Senko Tsukuda, Tomoe Kusayanagi, Yoichi Takakusagi, Kengo Morohashi …

BIOORGANIC & MEDICINAL CHEMISTRY, 23(18) 6118-6124, Sep, 2015 Peer-reviewed

Books and Other Publications

動き始めたがんゲノム医療‐深化と普及のための基礎研究課題‐

旦慎吾

羊土社, 2018
PI3K阻害剤の効果予測バイオマーカー

礒山翔, 矢守隆夫, 旦慎吾

ニューサイエンス社, 2014
最新がん薬物療法学-がんの薬物療法の最新知見-

旦慎吾

株式会社日本臨牀社, 2014
特集・制がん剤の分子標的スクリーニング成績化学療法基盤支援活動報告-制がん候補物質のスクリーニング成績・第15報-

矢守隆夫, 上原至雅, 深澤秀輔, 吉田稔, 井本正哉, 清宮啓之, 馬島哲夫, 水上民夫, 川田学, 長田裕之, 旦慎吾, 松浦正明, 掛谷秀昭, 冨田章弘

株式会社癌と化学療法社, 2013
がん分子標的治療

旦慎吾, 矢守隆夫

メディカルレビュー社, 2012
西尾和人編「がん分子標的薬治療の現状と展望」

旦慎吾, 矢守隆夫

ライフ・サイエンス, 2011
鶴尾隆編「がんの分子標的治療」

旦慎吾, 矢守隆夫

南山堂, 2008 (ISBN: 9784525420413)
分子細胞治療

旦慎吾, 矢守隆夫

株式会社先端医学社, 2003
血液・腫瘍科

旦慎吾, 矢守隆夫

科学評論社, 2003

Presentations

化合物を起点としたユニークながん治療標的の同定と治療薬の創製

旦慎吾

千葉県がんセンター研究所集談会, Jun 27, 2018, 千葉県がんセンター
がん分子標的治療の基本講座セッション21 「in vitro data の読み方」

旦慎吾

第22回日本がん分子標的治療学会, May, 2018
化合物を起点としたユニークながん治療標的の同定と治療薬の創製

旦慎吾

第143回お茶ノ水癌学アカデミア集会(順天堂大学), Apr 18, 2018, 順天堂大学
シンポジウム“がん個別化医療の革新を目指す新規治療戦略:がんの脆弱性”「ゴルジ体を標的としたユニークな抗がん物質M-COPAの同定とその抗がんメカニズム（指定演題）」

旦慎吾

第76回日本癌学会学術総会, Sep 30, 2017
Identification of a unique anticancer drug lead, M-COPA, by using JFCR39 cancer cell line panel: its mode of action and antitumor profile

旦慎吾

JSPS中国同窓会学術シンポジウム, Sep 2, 2017, JSPS中国同窓会
がん細胞パネルを用いたユニークな抗がん物質の同定と作用メカニズム解析

旦慎吾

早稲田大学理工学部/大学院理工学研究科講演会, Aug 23, 2016, 早稲田大学
乳癌発生・増殖におけるPI3Kシグナルの役割とそれを標的とした阻害剤の開発（シンポジウム指定演題）

旦慎吾

第22回日本乳癌学会学術総会, Jul, 2014
Year-in-Review: PI3K経路阻害剤

旦慎吾

第18回日本がん分子標的治療学会学術集会, Jun, 2014
がんにおける細胞内シグナル伝達の異常とそれを標的としたがん治療戦略

旦慎吾

第5回 Oncology 勉強会（大塚製薬株式会社）, Jun 27, 2013, 大塚製薬株式会社
PI3キナーゼ阻害剤の同定とそのトランスレーショナルリサーチ

旦慎吾

第21回乳癌基礎研究会, Jul 22, 2012
PI3K/Akt/mTOR経路の概略、PI3K阻害剤（シンポジウム指定演題）

旦慎吾

第9回日本臨床腫瘍学会学術集会, Jul, 2011
化合物バンク整備とがん研究への活用―化学療法基盤支援活動の支援事業とその利用法

旦慎吾

文部科学省科学研究費補助金・新学術領域研究・がん支援活動・化学療法基盤支援活動キックオフシンポジウム「アカデミアからの抗がん剤創薬へ向けて」, Mar 9, 2011
未来の分子標的薬はどうやって作られる？

旦慎吾

がんプロ新潟セミナー, Mar 4, 2011
がん細胞パネルに立脚したバイオロジーとインフォマティクスの連携によるPI3K阻害剤の分子薬理解明（奨励賞受賞講演）

旦慎吾, 矢守隆夫

第69回日本癌学会学術総会, Sep, 2010
Selective induction of apoptosis in Philadelphia chromosome-positive K562 cells by an inhibitor of BCR-ABL tyrosine kinase, CGP 57148

旦慎吾

2nd Japanese Foundation for Cancer Research-International Symposium on Cancer Chemotherapy, Oct 15, 1997

Teaching Experience

Professional Memberships

Research Projects

Industrial Property Rights

特願2017-064866 第四世代EGFRチロシンキナーゼ阻害剤

がん研究会, 矢守隆夫, 旦慎吾, 長崎大, 岩尾正倫, 石橋郁人, 岩手医科大, 上原至雄, 西谷直之, 奥裕介
特願2012-085456 PI3K阻害剤耐性がん細胞用診断マーカー及び診断方法

矢守隆夫, 旦慎吾