MISC

1996年7月

Angiotensin II-induced renal responses in anesthetized rabbits: Effects of N(omega-)nitro-L-arginine methyl ester and losartan

EUROPEAN JOURNAL OF PHARMACOLOGY
  • Y Adachi
  • ,
  • K Hashimoto
  • ,
  • H Hisa
  • ,
  • M Yoshida
  • ,
  • M SuzukiKusaba
  • ,
  • S Satoh

308
2
開始ページ
165
終了ページ
171
記述言語
英語
掲載種別
DOI
10.1016/0014-2999(96)00298-1
出版者・発行元
ELSEVIER SCIENCE BV

Intrarenal arterial infusion of angiotensin II (4 ng/kg/min) reduced renal blood flow, glomerular filtration rate and urinary Na+ excretion (UNaV) without affecting fractional Na+ excretion (FENa) in anesthetized rabbits. Losartan (10 mu g/kg/min) abolished these angiotensin II-induced renal responses. The renal blood flow, glomerular filtration rate and UNaV responses were potentiated during intrarenal arterial infusion of N-omega-nitro-L-arginine methyl ester (L-NAME, 10 mu g/kg/min). A high dose of L-NAME (50 mu g/kg/min) also potentiated the renal blood flow and UNaV responses but not the glomerular filtration rate response. Angiotensin II reduced FENa during L-NAME infusion at either dose. In L-NAME-pretreated rabbits, losartan abolished the angiotensin ii-induced renal blood flow and glomerular filtration rate responses, but the reduction in FENa still remained. The present study suggests that in the rabbit kidney (1) nitric oxide attenuates the angiotensin II-induced (angiotensin AT1 receptor-mediated) vasoconstriction and (2) angiotensin II can evoke losartan-resistant tubular Na+ reabsorption, but the tubular action is concealed by nitric oxide.

リンク情報
DOI
https://doi.org/10.1016/0014-2999(96)00298-1
CiNii Articles
http://ci.nii.ac.jp/naid/80009105881
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/8840128
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1996UZ61100009&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/0014-2999(96)00298-1
  • ISSN : 0014-2999
  • CiNii Articles ID : 80009105881
  • PubMed ID : 8840128
  • Web of Science ID : WOS:A1996UZ61100009

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