論文

査読有り
2017年8月

A comparison of five partial volume correction methods for Tau and Amyloid PET imaging with [F-18]THK5351 and [C-11]PIB

ANNALS OF NUCLEAR MEDICINE
  • Miho Shidahara
  • ,
  • Benjamin A. Thomas
  • ,
  • Nobuyuki Okamura
  • ,
  • Masanobu Ibaraki
  • ,
  • Keisuke Matsubara
  • ,
  • Senri Oyama
  • ,
  • Yoichi Ishikawa
  • ,
  • Shoichi Watanuki
  • ,
  • Ren Iwata
  • ,
  • Shozo Furumoto
  • ,
  • Manabu Tashiro
  • ,
  • Kazuhiko Yanai
  • ,
  • Kohsuke Gonda
  • ,
  • Hiroshi Watabe

31
7
開始ページ
563
終了ページ
569
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s12149-017-1185-0
出版者・発行元
SPRINGER

Purpose To suppress partial volume effect (PVE) in brain PET, there have been many algorithms proposed. However, each methodology has different property due to its assumption and algorithms. Our aim of this study was to investigate the difference among partial volume correction (PVC) method for tau and amyloid PET study.
Methods We investigated two of the most commonly used PVC methods, Muller-Gartner (MG) and geometric transfer matrix (GTM) and also other three methods for clinical tau and amyloid PET imaging. One healthy control (HC) and one Alzheimer's disease (AD) PET studies of both [F-18]THK5351 and [C-11]PIB were performed using a Eminence STARGATE scanner (Shimadzu Inc., Kyoto, Japan). All PET images were corrected for PVE by MG, GTM, Labb, (LABBE), Regional voxel-based (RBV), and Iterative Yang (IY) methods, with segmented or parcellated anatomical information processed by FreeSurfer, derived from individual MR images. PVC results of 5 algorithms were compared with the uncorrected data.
Results In regions of high uptake of [F-18]THK5351 and [C-11]PIB, different PVCs demonstrated different SUVRs. The degree of difference between PVE uncorrected and corrected depends on not only PVC algorithm but also type of tracer and subject condition.
Conclusions Presented PVC methods are straight-forward to implement but the corrected images require careful interpretation as different methods result in different levels of recovery.

Web of Science ® 被引用回数 : 11

リンク情報
DOI
https://doi.org/10.1007/s12149-017-1185-0
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000406047800009&DestApp=WOS_CPL