2007年6月
Self-assembling peptide inspired by a barnacle underwater adhesive protein
BIOMACROMOLECULES
- ,
- ,
- 巻
- 8
- 号
- 6
- 開始ページ
- 1830
- 終了ページ
- 1835
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/bm0612236
- 出版者・発行元
- AMER CHEMICAL SOC
An underwater bioadhesive generally comprises a multiprotein complex that provides a molecular basis for self-assembly. We report here a new class of self-assembling peptide inspired by a 20 kDa barnacle cement protein. Studies on the chemically synthesized 24-residue peptide have revealed that (1) it underwent irreversible self-assembly upon the addition of salt, (2) the self-assembly was started at a salt concentration close to that of seawater with noncovalent intermolecular interactions, (3) the self-assembled material resembled a macroscopic membrane of interwoven nanofilaments, (4) incubation in an alkaline pH range formed the intramolecular disulfide bond of a peptide molecule, thus triggering a conformation change of the molecule, and (5) conformational change of the building block promoted the formation of a nanofiber, resulting in the display of a three-dimensional meshlike mesoscopic structure with defined pores having a diameter of approximately 200 nm. The peptide is likely to provide a suitable basis for further development of peptide-based materials.
- リンク情報
- ID情報
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- DOI : 10.1021/bm0612236
- ISSN : 1525-7797
- PubMed ID : 17518440
- Web of Science ID : WOS:000247107900010