MIYAZAKI Tadaaki

J-GLOBAL         Last updated: Aug 9, 2014 at 14:36
 
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Name
MIYAZAKI Tadaaki
Affiliation
Hokkaido University
Section
Institute for Genetic Medicine
Job title
Professor
Degree
ph. D.(Osaka University)

Research Areas

 

Academic & Professional Experience

 
1982
 - 
1988
Researcher of the Institute of Rhoto
 
 
   
 
Pharmaceutical company
 
1988
 - 
1995
Researcher of Nippon Boeringer Ingerheim Research
 
 
   
 
Center, Molecular and Cellular Biologogy
 
 
   
 
Department
 

Education

 
 
 - 
1995
Medical research course, Graduate School, Division of Medicine, Osaka University
 
 
 - 
1982
Faculty of Pharmaceutical Science, Kyoto University
 

Published Papers

 
Lactobacillus gasseri SBT2055 induces TGF-b expression in dendritic
MIYAZAKI Tadaaki
PLos one      2014   [Refereed]
MIYAZAKI Tadaaki
Scientific Reports   4(10) 4638   2014   [Refereed]
MIYAZAKI Tadaaki
Nature Commun   4(14) 2763   2013   [Refereed]
MIYAZAKI Tadaaki
Biochem Biophys Res Commun   22 441   2013   [Refereed]
MIYAZAKI Tadaaki
Jpn J Infect Dis   65(5) 383-391   2012   [Refereed]
Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak-signaling pathway.
MIYAZAKI Tadaaki
Genes & Development   12(6) 770-775   1998   [Refereed]
An improved retroviral gene transfer technique demonstrates inhibition of CD4-CD8- thymocyte development by kinase-inactive ZAP-70.
MIYAZAKI Tadaaki
J. Immunol   161(6) 2888-2894   1998   [Refereed]
A critical role for cyclin C in promotion of the hematopoietic cell cycle by cooperation with c-Myc
MIYAZAKI Tadaaki
Mol. Cell. Biol., 1998;18(6):3445-3454.   18(6) 3445-3454   1998   [Refereed]
MIYAZAKI Tadaaki
Oncogene   14(13) 1629-1633   1997   [Refereed]
MIYAZAKI Tadaaki
Nature   387(6636) 921-924   1997   [Refereed]
Selective cooperation of HTLV-1-encoded p40tax-1 with cellular oncoproteins in the induction of hematopoietic cell proliferation
MIYAZAKI Tadaaki
Oncogene   12 2403-2408   1996   [Refereed]
Coupling of the IL2 receptor complex with non-receptor protein tyrosine kinases
MIYAZAKI Tadaaki
Cancer surveys   27 25-40   1996   [Refereed]
Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine-rich region within IL-2 receptor beta c chain.
MIYAZAKI Tadaaki
Blood   88 4118-4123   1996   [Refereed]
Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor; Possible link with the c-myc induction pathway.
MIYAZAKI Tadaaki
Immunity   2 89-100   1995   [Refereed]
MIYAZAKI Tadaaki
Annals of the New York Academy of Sciences   766 235-244   1995   [Refereed]
Signal transduction mediated by the reconstituted IL-2 receptor. Evidence for a cell type-specific function of IL-2 receptor beta-chain
MIYAZAKI Tadaaki
J.Immunol   152 5680-5690   1994   [Refereed]
MIYAZAKI Tadaaki
Science   266(5187) 1045-1047   1994   [Refereed]
MIYAZAKI Tadaaki
Annu. Rev. Immunol   11 245-268   1993   [Refereed]
The integrity of the conserved "WS motif" common to IL-2 and other cytokine receptors is essential for ligand binding and signal transduction
MIYAZAKI Tadaaki
BO J   10 3191-3197   1991   [Refereed]
The effect of ofloxacin on experimental periodontitis in hamsters infected with Actinomyces viscosus ATCC 15987
MIYAZAKI Tadaaki
J. Periodontol   30(3) 836-843   1988   [Refereed]
MIYAZAKI Tadaaki
Nat. Immunol   2(6) 493-500   2001   [Refereed]
Matsui Y, Okamoto H, Inobe M, Jia N, Shimizu T, Akino M, Sugawara T, Tezuka K, Nakayama Y, Morimoto J, Kimura C, Kon S, Miyazaki T, Kitabatake A, Uede T
Human gene therapy   14 521-532   Apr 2003   [Refereed]
Tosa N, Murakami M, Jia WY, Yokoyama M, Masunaga T, Iwabuchi C, Inobe M, Iwabuchi K, Miyazaki T, Onoe K, Iwata M, Uede T
International immunology   15(6) 741-749   Jun 2003   [Refereed]
Morimoto J, Inobe M, Kimura C, Kon S, Diao H, Aoki M, Miyazaki T, Denhardt DT, Rittling S, Uede T
International immunology   16(3) 477-488   Mar 2004   [Refereed]
Miyazaki T, Shen M, Fujikura D, Tosa N, Kim HR, Kon S, Uede T, Reed JC
The Journal of biological chemistry   279(43) 44667-44672   Oct 2004   [Refereed]
Watanabe K, Saito K, Kinjo M, Matsuda T, Tamura M, Kon S, Miyazaki T, Uede T
Biochemical and biophysical research communications   324(4) 1264-1273   Nov 2004   [Refereed]
Nitta T, Nasreen M, Seike T, Goji A, Ohigashi I, Miyazaki T, Ohta T, Kanno M, Takahama Y
PLoS biology   4 e103   Apr 2006   [Refereed]
Murata Y, Wakoh T, Uekawa N, Sugimoto M, Asai A, Miyazaki T, Maruyama M
FEBS letters   580(26) 6093-6099   Nov 2006   [Refereed]
Kim HR, Chae HJ, Thomas M, Miyazaki T, Monosov A, Monosov E, Krajewska M, Krajewski S, Reed JC
FASEB journal : official publication of the Federation of American Societies for Experimental Biology   21(1) 188-196   Jan 2007   [Refereed]
LKB1 is crucial for TRAIL-mediated apoptosis induction in osteosarcoma.
Takeda S, Iwai A, Nakashima M, Fujikura D, Chiba S, Li HM, Uehara J, Kawaguchi S, Kaya M, Nagoya S, Wada T, Yuan J, Rayter S, Ashworth A, Reed JC, Yamashita T, Uede T, Miyazaki T
Anticancer research   27 761-768   Mar 2007   [Refereed]
Kanayama M, Kurotaki D, Morimoto J, Asano T, Matsui Y, Nakayama Y, Saito Y, Ito K, Kimura C, Iwasaki N, Suzuki K, Harada T, Li HM, Uehara J, Miyazaki T, Minami A, Kon S, Uede T
Journal of immunology (Baltimore, Md. : 1950)   182(12) 8015-8025   Jun 2009   [Refereed]
Tosa N, Iwai A, Tanaka T, Kumagai T, Nitta T, Chiba S, Maeda M, Takahama Y, Uede T, Miyazaki T
Biochemical and biophysical research communications   395(3) 356-360   May 2010   [Refereed]
Matsuda M, Suizu F, Hirata N, Miyazaki T, Obuse C, Noguchi M
Biochemical and biophysical research communications   395(3) 312-317   May 2010   [Refereed]
Iwai A, Shiozaki T, Kawai T, Akira S, Kawaoka Y, Takada A, Kida H, Miyazaki T
The Journal of biological chemistry   285(42) 32064-32074   Oct 2010   [Refereed]
Harada T, Iwai A, Miyazaki T
Apoptosis : an international journal on programmed cell death   15(10) 1247-1255   Oct 2010   [Refereed]
Iwai A, Takegami T, Shiozaki T, Miyazaki T
PloS one   6 e20718   2011   [Refereed]
Fujioka Y, Tsuda M, Hattori T, Sasaki J, Sasaki T, Miyazaki T, Ohba Y
PloS one   6 e16324   Jan 2011   [Refereed]
Hayakawa S, Shiratori S, Yamato H, Kameyama T, Kitatsuji C, Kashigi F, Goto S, Kameoka S, Fujikura D, Yamada T, Mizutani T, Kazumata M, Sato M, Tanaka J, Asaka M, Ohba Y, Miyazaki T, Imamura M, Takaoka A
Nature immunology   12(1) 37-44   Jan 2011   [Refereed]
Shiozaki T, Iwai A, Kawaoka Y, Takada A, Kida H, Miyazaki T
The Journal of general virology   92(2) 315-325   Feb 2011   [Refereed]
Shinka T, Onodera D, Tanaka T, Shoji N, Miyazaki T, Moriuchi T, Fukumoto T
Oncology letters   2 211-215   Mar 2011   [Refereed]
Kim E, Okumura M, Sawa H, Miyazaki T, Fujikura D, Yamada S, Sugahara K, Sasaki M, Kimura T
Biochemical and biophysical research communications   409(4) 717-722   Jun 2011   [Refereed]
Morimoto J, Sato K, Nakayama Y, Kimura C, Kajino K, Matsui Y, Miyazaki T, Uede T
Journal of immunology (Baltimore, Md. : 1950)   187(11) 5671-5683   Dec 2011   [Refereed]
Muto NA, Sunden Y, Hattori T, Fujikura D, Nakayama Y, Miyazaki T, Maruyama M, Kimura T, Sawa H
Japanese journal of infectious diseases   65(5) 383-391   2012   [Refereed]
Muramatsu D, Iwai A, Aoki S, Uchiyama H, Kawata K, Nakayama Y, Nikawa Y, Kusano K, Okabe M, Miyazaki T
PloS one   7 e41399   2012   [Refereed]
Sato K, Iwai A, Nakayama Y, Morimoto J, Takada A, Maruyama M, Kida H, Uede T, Miyazaki T
Biochemical and biophysical research communications   417(1) 274-279   Jan 2012   [Refereed]
Kondoh M, Fukada K, Fujikura D, Shimada T, Suzuki Y, Iwai A, Miyazaki T
Viral immunology   25 86-90   Feb 2012   [Refereed]
MIYAZAKI Tadaaki
Kampo Medicine   63(6) 363-368   Jun 2012
Uchiyama H, Iwai A, Asada Y, Muramatsu D, Aoki S, Kawata K, Kusano K, Nagashima K, Yasokawa D, Okabe M, Miyazaki T
BMC research notes   5 189   Jun 2012   [Refereed]
Miyazaki T
Nihon yakurigaku zasshi. Folia pharmacologica Japonica   140(2) 62-65   Aug 2012   [Refereed]
Fujikura D, Chiba S, Muramatsu D, Kazumata M, Nakayama Y, Kawai T, Akira S, Kida H, Miyazaki T
PloS one   8 e55321   2013   [Refereed]

Misc

 
Kametaka, S., Miyazaki, T., Inoue, Y., Hayashi, S., Takamori, A., Miyake, Y. and Suginaka, H. The effect of ofloxacin on experimental periodontitis in hamsters infected with Actinomyces viscosus ATCC 15987.
J. Periodontol., 1989; 5; 60, 285-291.   
Miyazaki, T., Maruyama, M., Yamada, G., Hatakeyama, M. and Taniguchi, T. The integrity of the conserved "WS motif"common to IL-2 and other cytokine receptors is essential for ligand binding and signal transduction.
EMBO J., 1991; 10; 3191-3197.   
P. N. A. S., 1933; 90; 4201-4205.   
Kobayashi, N., Kono, T., Hatakeyama, M., Minami, Y., Miyazaki, T., Perlmutter, R. M. and Taniguchi, T. Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56/yn with the interleukin 2 receptor; Implications for redundan...
Minami, Y., Kono, T., Miyazaki, T. and Taniguchi, T. The IL-2 receptor complex; Its structure, function,and target genes.
Annu. Rev. Immunol., 1993; 11; 245-267.   
Minami, Y., Oishi, I., Liu, Z. J., Nakagawa, S., Miyazaki, T. and Taniguchi, T. Signal transduction mediated by the reconstituted IL-2 receptor. Evidence for a cell type-specific function of IL-2 receptor beta-chain.
J. Immunol., 1994; 152; 5680-5690.   

Books etc

 
Pathogenesis of lnfluenza and Effects of Herdal Medicines
MIYAZAKI Tadaaki
Nov 2012   
Inhibitiion of the Replication of Influenza A Virus by a Component “BR-p³”of Dolomite
MIYAZAKI Tadaaki (Part:Joint Work)
Sep 2012   
Coupling of the IL2 receptor complex with non-receptor protein tyrosine kinases.
MIYAZAKI Tadaaki (Part:Joint Work)
Cold Spring Harbor Laboratory Pr; illustrated版   1997   
Taniguchi, T. The IL-2 receptor complex; Its structure, function, and target genes.
MIYAZAKI Tadaaki (Part:Joint Work)
Annual Reviews   1993   
The functional role of the glucocorticoid receptor(Gr) and Nur77 in thymocyte development
MIYAZAKI Tadaaki (Part:Joint Work)
NOVA Publishers   2011   
Caspase-8: Properties, Functions and Regulation
MIYAZAKI Tadaaki (Part:Joint Work)

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2005 - 2006    Investigator(s): Tadaaki MIYAZAKI
Despite improvements in chemotherapy and surgery in the treatment of osteosarcoma, satisfactory results are still difficult to achieve. New therapeutic modalities need to be developed for these treatments. TRAIL (TNF-related apoptosis inducing lig...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(A))
Project Year: 2004 - 2006    Investigator(s): Toshimitsu UEDE
It has been shown that the cryptic epitope, S162VVYGLR168, is exposed by the cleavage of human osteopontin (OPN) by thrombin and this epitope is recognized by a 4 and a 9 integrins.1) We found that V164, Y105 and L167 residues are critical for the...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2003 - 2005    Investigator(s): Masataka KINJO
Different distribution of many materials, pH, ion, or oxygen concentration can be detected in living cell according to the different position in the cell such as near or away from plasma membrane, nucleus, endsome or mitochondrion. Microenvironmen...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1996 - 1997    Investigator(s): Tadaaki MIYAZAKI
IL-2 signal is transmitted by IL-2 receptor complex composed of alpha, beta and gamma chains. At least three signaling pathways have been demonstrated to be linked to the IL-2R ; the src-family PTK-linked c-fos/c-jun induction pathway, the c-myc i...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(A), 基盤研究(A))
Project Year: 1995 - 1997    Investigator(s): Tadatsugu TANIGUCHI
The present study has been focused on the elucidation of the molecular mechanisms underlying requlation of host defense, including the regulation of the immune system and oncogenesis.First, we studied the roles of the IRF family transcription fact...

Patents

 
特許5451703 : II肺胞上皮細胞活性剤
MIYAZAKI Tadaaki
特願2012-526548 : 免疫アジュバント
MIYAZAKI Tadaaki