Masayuki Yokoi

J-GLOBAL         Last updated: Oct 18, 2019 at 15:33
 
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Name
Masayuki Yokoi
Affiliation
Kobe University
Section
Biosignal Research Center
Job title
Associate Professor
Degree
Dr. Science

Research Areas

 

Academic & Professional Experience

 
 
 - 
2002
2000 Apr.-2002 Mar.: Research Associate, IMCB,
 
2002
   
 
Apr.-present : Research Associate, FBS,
 
 
 - 
2000
1999 Aug.-2000 Mar.: Special Postdoctoral Researcher,
 
 
 - 
1999
1998 Aug.-1999 Mar.: Fellow in Cancer Research of the
 
 
   
 
Osaka University
 
 
   
 
Osaka University
 
 
   
 
RIKEN
 
 
   
 
Japan Society for the Promotion of Science
 

Published Papers

 
Mechanism and regulation of DNA damage recognition in nucleotide excision repair
KUSAKABE MASAYUKI, ONISHI YUKI, TADA HARUTO, KURIHARA FUMIKA, KUSAO KANAKO, FURUKAWA MARI, IWAI SHIGENORI, YOKOI MASAYUKI, SAKAI WATARU, SUGASAWA KAORU
Genes and Environment   41 2   Jan 2019   [Refereed]
Akagi,J., Yokoi,M., Cho,Y-M., Toyoda,T., Ohmori,H., Hanaoka,F., Ogawa,K.
DNA Repair   61 76-85   Jan 2018   [Refereed]
Nakamura,T., Murakami,K., Tada,H., Uehara,Y., Nogami,J., Maehara,K., Ohkawa,Y., Saitoh,H., Nishitani,H., Ono,T., Nishi,R., Yokoi,M., Sakai,W., Sugasawa, K.
Genes Cells   22(4) 392-405   Apr 2017   [Refereed]
Kakumu,E., Nakanishi,S., Shiratori,H., Kato,A., Kobayashi,W., Machida,S., Yasuda,T., Adachi,N., Saito,N., Ikura,T., Kurumizaka,H., Kimura,H., Yokoi,M., Sakai,W., Sugasawa, K.
Genes Cells   22(3) 310-27   Mar 2017   [Refereed]
Kanao,R., Yokoi,M., Ohkumo,T., Sakurai,Y, Dotsu,K., Kura,S, Nakatsu,Y, Tsuzuki,T, Masutani,C, Hanaoka,F.
DNA Repair   29 139-146   2015   [Refereed]
Ito,W., Yokoi,M., Sakayoshi, N., Sakurai,Y., Akagi,J., Mitani,H., Hanaoka,F.
Genes Cells   17 98-108   2012   [Refereed]
Ultraviolet A photolysis of 8-methoxypsoralen (PUVA) and trioxsalen generating reactive oxygen species only by former agent, sensitivity of mdh, sdh, zhd, nuo and sod mutants of Escherichia coli to PUVA: implications on certain diseases of DNA repair defi
Ahmad,S.I., Yokoi,M., Hanaoka,F.
J. Photochem. Photobiol. B   116 30-36   2012   [Refereed]
Masuda,K., Ouchida,R., Yokoi,M., Hanaoka,F., Azuma,T., Wang,J.Y.
Eur. J. Immunol.   38 2796-2805   2008   [Refereed]
T during somatic hypermutation of Ig genes
Masuda,K., Ouchida,R., Hikida,M., Kurosaki,T., Yokoi,M., Masutani,C., Seki,M., Wood,R.D., Hanaoka,F., Wang,J.Y.
J. Biol. Chem.   282 17387-17394   2007   [Refereed]
Martomo,S.A., Yang,W.W., Vaisman,A., Maas,A., Yokoi,M., Hoeijmakers,J.H., Hanaoka,F., Woodgate,R., Gearhart,P.J.
DNA Repair   5 392-398   2006   [Refereed]
Okuma,T., Kondo,Y., Yokoi,M., Tsukamoto,T., Yamada,A., Sugimoto,T., Kanao,R., Higashi,Y., Kondoh,H., Tatematsu,M., Masutani,C., Hanaoka,F.
Mol. Cell. Biol.   26 7696-7706   2006   [Refereed]
Martomo,S.A., Yang,W.W., Wersto,R.P., Ohkumo,T., Kondo,Y., Yokoi,M., Masutani,C., Hanaoka,F., Gearhart,P.J.
Proc. Natl. Acad. Sci. USA   102 8656-8661   2005   [Refereed]
Nishikawa,N.S., Izumi,M., Yokoi,M., Miyazawa,H., Hanaoka,F.
Genes Cells   6 57-70   2001   [Refereed]
Nishikawa,N.S., Izumi,M., Ucida,H., Yokoi,M., Miyazawa,H., Hanaoka,F.
Nucleic Acids Res.   28 1525-1534   2000   [Refereed]
Izumi,M., Yanagi,K., Mizuno,T., Yokoi,M., Kawasaki,Y., Moon,K., Hurwits,J., Yatagai,F, Hanaoka,F.
Nucleic Acids Res.   28 4769-4777   2000   [Refereed]
Yokoi,M., Masutani,C., Maekawa,T., Sugasawa,K., Ohkuma,Y., Hanaoka,F.
J. Biol. Chem.   275 9870-9875   2000   [Refereed]
Izumi,M., Yokoi,M., Nishikawa,N., Miyazawa,H., Sugino,A., Yamagishi,M., Yamaguchi,M., Matsukage,A., Yatagai,F, Hanaoka,F.
Biochim. Biophys. Acta   1492 341-352   2000   [Refereed]
Hiyama,H., Yokoi,M., Masutani,C., Sugasawa,K., Maekawa,T., Tanaka,K., Hoeijmakers,J.H.J., Hanaoka,F.
J. Biol. Chem.   274 28019-28025   1999   [Refereed]
Masutani,C., Kusumoto,R., Yamada,A., Dohmae,N., Yokoi,M., Yuasa,M., Araki,M., Iwai,S., Takio,K., Hanaoka,F.
Nature   399 700-704   1999   [Refereed]
The second-largest subunit of the mouse DNA polymerase α-primase complex facilitates both production and nuclear translocation of the catalytic subunit of DNA polymerase α
Mizuno,T., Ito,N., Yokoi,M., Kobayashi,A., Tamai,K., Miyazawa,H., Hanaoka,F.
Mol. Cell. Biol.   18 3552-3562   1998   [Refereed]
Yokoi,M., Ito,M., Izumi,M., Miyazawa,H., Nakai,H., Hanaoka,F.
Genes Cells   2 695-709   1997   [Refereed]
Identification of the nuclear localization signal of mouse DNA primase: nuclear transport of p46 subunit is facilitated by interaction with p54 subunit
Mizuno,T., Okamoto,T., Yokoi,M., Izumi,M., Kobayashi,A., Hachiya,T., Tamai,K., Inoue,T., Hanaoka,F.
J. Cell Sci.   109 2627-2636   1996   [Refereed]

Misc

 
Yokoi,M., Hanaoka,F.
Gene   597 1-9   Jan 2017   [Refereed]
立体構造解析から見えてきた損傷乗り越えDNA複製の分子メカニズム
道津貫太郎, 横井雅幸, 花岡文雄
放射線生物研究   46 1-14   2011
哺乳類の多様なDNAポリメラーゼと疾患との関連
横井雅幸, 花岡文雄
G.I. Research   18 115-122   2010
MASUDA Keiji, OUCHIDA Rika, HIKIDA Masaki, KUROSAKI Tomohiro, YOKOI Masayuki, YOKOI Masayuki, MASUTANI Chikahide, MASUTANI Chikahide, SEKI Mineaki, WOOD Richard D., HANAOKA Fumio, HANAOKA Fumio, O‐WANG Jiyang
J. Biol. Chem.   282(24) 17387-17394   2007
OHKUMO Tsuyoshi, KONDO Yuji, YOKOI Masayuki, YOKOI Masayuki, TSUKAMOTO Tetsuya, YAMADA Ayumi, SUGIMOTO Taiki, KANAO Rie, HIGASHI Yujiro, KONDOH Hisato, TATEMATSU Masae, MASUTANI Chikahide, MASUTANI Chikahide, HANAOKA Fumio, HANAOKA Fumio, HANAOKA Fumio
Mol. Cell. Biol.   26(20) 7696-7706   2006
MARTOMO Stella A., YANG William W., VAISMAN Alexandra, MAAS Alex, YOKOI Masayuki, HOEIJMAKERS Jan H., HANAOKA Fumio, HANAOKA Fumio, WOODGATE Roger, GEARHART Patricia J.
DNA Repiar   5(3) 392-398   2006
SANO S, CHAN Ks, KIRA M, KATAOKA K, TAKAGI S, TARUTANI M, ITAMI S, KIGUCHI K, YOKOI M, SUGASAWA K, MORI T, HANAOKA F, TAKEDA J, DIGIOVANNI J
Cancer Res.   65(13) 5720-5729   2005
MARTOMO Stella A, YANG William W, WERSTO Robert P, OHKUMO Tsuyoshi, KONDO Yuji, YOKOI Masayuki, MASUTANI Chikahide, HANAOKA Fumio, HANAOKA Fumio, GEARHART Patricia J
Proc Natl Acad Sci U S A.   102(24) 8656-8661   2005
HAYASHI Kazuhiro, WATANABE Tomomichi, TANAKA Aki, FURUMOTO Tadashi, SATO‐TSUCHIYA Chiaki, KIMURA Makoto, YOKOI Masayuki, ISHIHAMA Akira, HANAOKA Fumio
Genes Cells   10(3) 207-224   2005
FUKUMOTO Y, HIYAMA H, YOKOI M, NAKASEKO Y, YANAGIDA M, HANAOKA F
DNA Repair   1(10) 833-845   2002
UCHIDA A, SUGASAWA K, MASUTANI C, DOHMAE N, ARAKI M, YOKOI M, OHKUMA Y, HANAOKA F
DNA Repair   1(6) 449-461   2002
NISHIKAWA N S, IZUMI M, YOKOI M, MIYAZAWA H, HANAOKA F
Genes Cells   6(1) 57-70   2001
Xeroderma pigmentosum variant: From a human genetic disorder to a novel DNA polymerase
Cold Spring Habor Symposia on Quantitative Biology   65 71-80   2000
IZUMI M, YANAGI K, MIZUNO T, YOKOI M, KAWASAKI Y, MOON K‐Y, HURWITZ J, YATAGAI F, HANAOKA F
Nucleic Acid Res.   28(23) 4769-4777   2000
IZUMI M, YOKOI M, NISHIKAWA N S, MIYAZAWA H, HANAOKA F, SUGINO A, YAMAGISHI M, YAMAGUCHI M, MATSUKAGE A
Biochim. Biophys. Acta   1492(2/3) 341-352   2000
YOKOI M, MASUTANI C, MAEKAWA T, SUGASAWA K, OHKUMA Y, HANAOKA F
J. Biol. Chem.   275(13) 9870-9875   2000
NISHIKAWA N S, IZUMI M, UCHIDA H, YOKOI M, MIYAZAWA H, HANAOKA F
Nucleic Acids Res.   28(7) 1525-1534   2000
Xeroderma pigmentosum variant: from a human genetic disorder to a novel DNA polymerase
Masutani,C., Kusumoto,R., Yamada,A., Yuasa,M., Arakai,M., Nogimori,T., Yokoi,M., Eki,T., Iwai,S., Hanaoka,F.
Cold Spring Harb. Symp. Quant. Biol.   65 71-80   2000   [Refereed]
皮膚癌と基本転写因子
横井雅幸, 花岡文雄, 大熊芳明
現代医療   32 473-480   2000
HIYAMA H, YOKOI M, MASUTANI C, SUGASAWA K, MAEKAWA T, TANAKA K, HOEIJMAKERS J H J, HANAOKA F
J. Biol. Chem.   274(39) 28019-28025   1999
MASUTANI C, KUSUMOTO R, YAMADA A, DOHMAE N, YOKOI M, YUASA M, ARAKI M, IWAI S, HANAOKA F
Nature   399(6737) 700-704   1999
The second-largest subunit of the mouse DNA polymerase alpha-primase complex facilitates both production and nuclear translocation of the catalytic of DNA polymerase alpha
Mol. Cell. Biol.   18(6) 3552-3562   1998
YOKOI M, ITO M, IZUMI M, MIYAZAWA H, NAKAI H, HANAOKA F
Genes Cells   2(11) 695-709   1997
DNA修復と細胞周期制御
横井雅幸, 益谷央豪, 花岡文雄
蛋白質 核酸 酵素   41 1791-1798   1996

Books etc

 
紫外線によるDNAの損傷とがん化のメカニズム
Yokoi,M., Sugasawa, K. (Part:Joint Work)
技術情報協会   Oct 2016   

Conference Activities & Talks

 
Benzo[a]pyrene-induced tumorigenesis in Polκ-knockout mice
AKAGI JUNICHI, CHO Young-Man, TOYODA TAKESHI, YOKOI MASAYUKI, HANAOKA FUMIO, OHMORI HARUO, OGAWA KUMIKO
The 11th 3R+3C Symposium   Nov 2018   
DNAポリメラーゼ・イータと脱ユビキチン化酵素の相互作用の解析
案済 萌, 西村 潤, 菅野新一郎, 安井 明, 菅澤 薫, 花岡文雄, 横井雅幸
第41回日本分子生物学会年会   Nov 2018   
N7-glycidamide-dG adduct inhibits DNA replication in mammalian cells
AKAGI JUNICHI, YOKOI MASAYUKI, CHO YOUNG-MAN, YAMAMOTO J, MIZUTA YASUKO, IWAI SHIGENORI, HANAOKA FUMIO, OGAWA KUMIKO
第41回日本分子生物学会年会   Nov 2018   
Translesion synthesis-associated chromatin remodeling factors contribute the function of human DNA polymerase η in cisplatin-treated cells.
Masayuki Yokoi, Yuuki Shikaya, Kaoru Sugasawa, Fumio Hanaoka
The 11th 3R&3C Symposium   Nov 2018   
XPCタンパク質によるDNA損傷認識の制御におけるヒストン修飾の役割
KURIHARA FUMIKA, KUSAKABE MASAYUKI, KATO AKARI, KAKUMU ERINA, NAKANISHI SEIYA, KUSAO KANAKO, OKAWA YASUYUKI, YOKOI MASAYUKI, SAKAI WATARU, SUGASAWA KAORU
第41回日本分子生物学会年会   Nov 2018   
Effect of Polκ deficiency on benzo[a]pyrene-induced tumorigenesis
AGAGI JUNICHI, YOUNG-MAN CHO, TOYODA TAKESHI, YOKOI MASAYUKI, HANAOKA FUMIO, OGAWA KUMIKO
The 5th DNA polymerase meeting   Sep 2018   
クロマチン構造を介したヌクレオチド除去修復の高次制御機構
日下部将之, 各務恵理菜, 加藤安佳梨, 栗原文佳, 草尾佳那子, 横井雅幸, 酒井 恒, SUGASAWA KAORU
第91回生化学会大会   Sep 2018   
Analysis of contribution of Polκ to benzo[a]pyrene-induced tumorigenesis
AKAGI Junichi, Young-Man Cho, TOYODA Takeshi, MIZUTA Yasuko, YOKOI Masayuki, HANAOKA Fumio, OHMORI Haruo, OGAWA Kumiko
日本薬学会第138年会   Mar 2018   
Analysis of contribution of Polκ to benzo[a]pyrene-induced tumorigenesis
AKAGI JUNICH, YOUNG-MAN CHO, TOYODA TAKESHI, MIZUTA YASUKO, YOKOI MASAYUKI, HANAOKA FUMIO, OMORI HARUO, OGAWA KUMIKO
日本薬学会第138回   Mar 2018   
DNA損傷による複製の停止を回避する機構とその制御
YOKOI Masayuki
神戸大学第6回バイオシグナル研究会   Mar 2018   
DNA損傷による複製の停止を回避する機構とその制御
YOKOI MASAYUKI
第6回バイオシグナル研究会   Mar 2018   
Contribution of Polκ to tumorigenesis in the forestomach of benzo[a]pyrene-fed mice
AKAGI JUNICHI, YOUNG-MAN CHO, TOYODA TAKESHI, MIZUTA YASUKO, YOKOI MASAYUKI, HANAOKA FUMIO, OHMORI HARUO, OGAWA KUMIKO
2017年度生命科学系学会合同年次大会   Dec 2017   
シスプラチン誘発DNA鎖内架橋の乗り越え合成に関わるヒストン修飾とクロマチン構造変換因子の探索
YOKOI MASAYUKI, SHIKAYA YUUKI, SUGASAWA KAORU, 花岡 文雄
第24回 DNA複製・組換え・修復ワークショップ   Nov 2017   
Chromatin remodeling factors contribute to the function of human DNA polymerase η in the cells treated with cisplatin
YOKOI MASAYUKI, SUGASAWA KAORU, HANAOKA FUMIO
第76回 日本癌学会   Sep 2017   
損傷乗り越え型DNAポリメラーゼ イータ・イオタ・カッパ三重欠損細胞を用いた新規遺伝毒性試験法の研究
AKAGI JUNICHI, YOKOI MASAYUKI, YONG-MAN CHO, TOYODA TAKESHI, OHMORI HARUO, HANAOKA FUMIO, OGAWA KUMIKO
日本薬学会レギュラトリーサイエンス部会   Sep 2017   
損傷乗り越え型DNAポリメラーゼ イータ・イオタ・カッパ三重欠損細胞を用いた新規遺伝毒性試験法の研究 [Invited]
AKAGI Junichi, YOKOI Masayuki, Young-Man Cho, TOYODA Takeshi, OHMORI Haruo, HANAOKA Fumio, OGAWA Kumiko
日本薬学会レギュラトリーサイエンス部会 第3回 次世代を担う若手のためのレギュラトリーサイエンスフォーラム   Sep 2017   
Functional analysis of human DNA polymerase eta harboring mutations in the palm domain
Yokoi,M., Mishima,K., Noda,C., Nishimura., Yang,W., Hanaoka,F.
第39回 日本分子生物学会年会   Dec 2016   日本分子生物学会
Structure and function relations of human DNA polymerase eta: mutations of the finger or little finger domains alter lesion bypass efficiencies
Yokoi,M., Onaka,S., Mishima,K., Yang,W., Hanaoka,F.
The 10th 3R Symposium   Nov 2016   10th 3R organizing committee
Translesion DNA polymerase η, ι, and κ triple knockout cells exhibit hypersensitivity to unmetabolized benzo[a]pyrene
Akagi, J., Yokoi, M., Cho, Y.-M., Toyota, T., Ohmori, H., Hanaoka, F., Ogawa, K.
第39回 日本分子生物学会   Nov 2016   
Triple knockout mouse fibroblast cells defective for DNA polymerases eta, iota, and kappa exhibit hypersensitivity to various genotoxic mechanisms and have potential for screening of chemical genotoxicity
Akagi,J., Yokoi,M., Cho,Y.-M., Toyota,T., Ohmori,H., Hanaoka,F., Ogawa,K.
The 10th 3R Symposium   Nov 2016   10th 3R organizing committee
Deficiency of Pols eta/iota/kappa exhibit different sensitivities to various chemicals and are useful for screening of genotoxity
Akagi,J., Yokoi,M., Cho,Y.-M., Toyota,T., Ohmori,H., Hanaoka,F., Ogawa,K.
第75回 日本癌学会学術総会   Oct 2016   日本癌学会
Mutant analyses of human DNA polymerase eta based on high-resolution crystal structures of the protein-DNA-dNTP complex [Invited]
Hanaoka,F, Yokoi,M., Masutani,C, Yang,W.
DNA polymerase Meeting: from Molecular Function to Human Diseases   Oct 2016   
ヒトPoletaの構造的特徴と損傷乗り越え活性の連関
Yokoi,M.
国立遺伝学研究所研究集会「生物ゲノム安定維持の分子機構」   Oct 2016   国立遺伝学研究所
Cancer and translesion synthesis polymerases: with special reference on UV-induced mutagenesis [Invited]
Sakurai,Y., Yokoi,M., Hanaoka,F.
Cold Spring Harbor Asia Conference: DNA Metabolism, Genomic Stability & Diseases   Jun 2016   Cold Spring Habor Laboratory

Teaching Experience

 

Research Grants & Projects

 
DNA metabolism and cell-cycle regulation