論文

2020年8月

Molecular state evaluation of active pharmaceutical ingredients in adhesive patches for transdermal drug delivery

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
  • Katsuhiko Gato
  • ,
  • Mika Yoshimura Fujii
  • ,
  • Hiroshi Hisada
  • ,
  • James Carriere
  • ,
  • Tatsuo Koide
  • ,
  • Toshiro Fukami

58
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.jddst.2020.101800
出版者・発行元
ELSEVIER

In this study, we prepared mock patches consisting of model drug (felbinac) and three types of acrylic polymers with different functional substituent and/or physical properties, and evaluated the correlation of pharmaceutical properties and molecular state of felbinac in these patches. Polarizing microscopic observation, powder X-ray diffraction and Raman spectroscopy were employed and then different propensity was observed in the crystallization behaviour and precipitated crystal form in each patches. In particular, Raman spectra in low frequency region were useful to detect polymorphic change in patches. H-1 NMR was also used to investigate the interaction between felbinac and the polymers. In addition, pharmaceutical properties of mock patches were evaluated by dissolution test and in vitro skin permeation test. From these results, crystallization of felbinac was occurred in the case of weaker interaction between felbinac and the polymer, which has carboxy group as substituent, and resulted in higher drug release and skin permeation. In conclusion, it was essential to consider the compatibility of drug and polymer, which constituted adhesive layer in patches, in molecular level.

リンク情報
DOI
https://doi.org/10.1016/j.jddst.2020.101800
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000551059800012&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.jddst.2020.101800
  • ISSN : 1773-2247
  • eISSN : 2588-8943
  • Web of Science ID : WOS:000551059800012

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