Naoshi Kojima - My portal

Profile Information

Affiliation: National Institute of Advanced Industrial Science and Technology

Degree: 博士（薬学）

Researcher number: 30356985
J-GLOBAL ID: 200901097147957329
researchmap Member ID: 5000005893

External link: http://www.aist.go.jp/RESEARCHERDB/cgi-bin/worker_detail.cgi?call=namae&rw_id=N28161338

Research Interests

Nucleic Acids Chemistry

Research Areas

Life sciences / Structural biochemistry /

Awards

Nov, 2010

2010年度日本薬学会北海道支部奨励賞, 核酸の機能解析と遺伝子解析技術の向上を目指した有機化学的アプローチ, 日本薬学会北海道支部

小島直

Papers

Immobilization of DNA with nitrogen mustard-biotin conjugate for global epigenetic analysis.

Naoshi Kojima, Tomomi Suda, Takaaki Kurinomaru, Ryoji Kurita

Analytica chimica acta, 1043 107-114, Dec 28, 2018 Peer-reviewed
An alkylating immobilization linker for immunochemical epigenetic assessment

Takaaki Kurinomaru, Naoshi Kojima, Ryoji Kurita

CHEMICAL COMMUNICATIONS, 53(59) 8308-8311, Jul, 2017 Peer-reviewed
Development of a 3 '-amino linker with high conjugation activity and its application to conveniently cross-link blunt ends of a duplex

Keiko Kowata, Naoshi Kojima, Yasuo Komatsu

BIOORGANIC & MEDICINAL CHEMISTRY, 24(9) 2108-2113, May, 2016 Peer-reviewed
Electrochemical Properties of Interstrand Cross-Linked DNA Duplexes Labeled with Nile Blue

Mie, Yasuhiro, Kowata, Keiko, Kojima, Naoshi, Komatsu, Yasuo

LANGMUIR, 28(49) 17211-17215, Dec, 2012 Peer-reviewed
End-tether Structure of DNA Alters Electron-transfer Pathway of Redox-labeled Oligo-DNA Duplex at Electrode Surface

Mie, Yasuhiro, Kojima, Naoshi, Kowata, Keiko, Komatsu, Yasuo

CHEMISTRY LETTERS, 41(1) 62-64, Jan, 2012 Peer-reviewed
Interstrand cross-link of DNA by covalently linking a pair of abasic sites

Kohei Ichikawa, Naoshi Kojima, Yu Hirano, Toshie Takebayashi, Keiko Kowata, Yasuo Komatsu

CHEMICAL COMMUNICATIONS, 48(15) 2143-2145, 2012 Peer-reviewed
Synthesis and application of highly reactive amino linkers for functional oligonucleotides

Naoshi Kojima, Yasuo Komatsu

Current Protocols in Nucleic Acid Chemistry, 1(48) 4.48.23-23, 2012 Peer-reviewed
Development of novel chemical reagents for reliable genetic analyses: Process from an original idea to marketing of a chemical product used for life science

Komatsu Y, Kojima N

Synthesiology, 3(3) 223-230, 2010 Peer-reviewed
Construction of Highly Reactive Probes for Abasic Site Detection by Introduction of an Aromatic and a Guanidine Residue into an Aminooxy Group

Naoshi Kojima, Toshie Takebayashi, Akiko Mikami, Eiko Ohtsuka, Yasuo Komatsu

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131(37) 13208-13209, Sep, 2009 Peer-reviewed
Efficient synthesis of oligonucleotide conjugates on solid-support using an (aminoethoxycarbonyl)aminohexyl group for 5 '-terminal modification

Naoshi Kojima, Toshie Takebayashi, Akiko Mikami, Eiko Ohtsuka, Yasuo Komatsu

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(8) 2144-2147, Apr, 2009 Peer-reviewed
Development of novel chemical probes to detect abasic sites in DNA.

Kojima N, Takebayashi T, Mikami A, Ohtsuka E, Komatsu Y

Nucleic acids symposium series (2004), (53) 45-46, 2009 Peer-reviewed
Novel amino linkers enabling efficient labeling and convenient purification of amino-modified oligonucleotides

Yasuo Komatsu, Naoshi Kojima, Maiko Sugino, Akiko Mikami, Ken Nonaka, Yumi Fujinawa, Takashi Sugimoto, Kousuke Sato, Kenichi Matsubara, Eiko Ohtsuka

BIOORGANIC & MEDICINAL CHEMISTRY, 16(2) 941-949, Jan, 2008 Peer-reviewed
Construction of an aminooxy derivative for RNA and DNA labeling.

Komatsu Y, Kojima N, Takebayashi T, Mikami A, Sugino M, Ohtsuka E

Nucleic acids symposium series (2004), (52) 393-394, 2008 Peer-reviewed
Comparison of the chemical properties of a novel amino-linker with various amino modifications.

Kojima N, Takebayashi T, Mikami A, Sugino M, Ohtsuka E, Komatsu Y

Nucleic acids symposium series (2004), (52) 463-464, 2008 Peer-reviewed
Nucleosides and Nucleotides. Part 207: Studies in the chemical conversion of the 4-carboxamide Group of 5-amino-1-beta-D-ribofuranosylimidazole-4-carboxamide (AICA-riboside). Application for the synthesis of 1-deazaguanosine

N Kojima, N Minakawa, A Matsuda

TETRAHEDRON, 56(40) 7909-7914, Sep, 2000 Peer-reviewed
Replacement of the phosphorodiester linkages of RNA with guanidinium linkages: the solid-phase synthesis of ribonucleic guanidine.

Kojima N, Bruice TC

Organic letters, Jan, 2000 Peer-reviewed
Nucleosides and nucleotides. 184. Synthesis and conformational investigation of anti-fixed 3-deaza-3-halopurine ribonucleosides

N Minakawa, N Kojima, A Matsuda

JOURNAL OF ORGANIC CHEMISTRY, 64(19) 7158-7172, Sep, 1999 Peer-reviewed
Nucleosides and nucleotides. 174. Synthesis of oligodeoxynucleotides containing 4 '-C-[2-[[N-(2-aminoethyl)carbamoyl]oxy]ethyl]thymidine and their thermal stability and nuclease-resistance properties

Y Ueno, Y Nagasawa, Sugimoto, I, N Kojima, M Kanazaki, S Shuto, A Matsuda

JOURNAL OF ORGANIC CHEMISTRY, 63(5) 1660-1667, Mar, 1998 Peer-reviewed
Synthesis and incorporation of tricyclic-imidazo[5',4':4,5]pyrido[2,3-d]pyrimidine nucleosides into oligonucleotides and their thermal stability.

Kojima N, Ueno Y, Minakawa N, Matsuda A

Nucleic acids symposium series, 1997 Peer-reviewed
Nucleosides and nucleotides .143. Synthesis of 5-amino-4-imidazolecarboxamide (AICA) deoxyribosides from deoxyinosines and their conversion into 3-deazapurine derivatives

N Minakawa, Y Sasabuchi, A Kiyosue, N Kojima, A Matsuda

CHEMICAL & PHARMACEUTICAL BULLETIN, 44(2) 288-295, Feb, 1996 Peer-reviewed

Misc.

シトシンバリアントの一括計測に向けたSPRイムノアッセイの開発

栗之丸隆章, 小島直, 栗田僚二

化学とマイクロ・ナノシステム学会研究会講演要旨集, 37th 12, May 21, 2018
エピゲノムのオンチップ分析向けたアルキル化リンカーの創成

栗田僚二, 栗之丸隆章, 小島直

化学とマイクロ・ナノシステム学会研究会講演要旨集, 36th 45, Oct 4, 2017
抗がん剤を有する新規リンカー分子を用いたメチル化DNA免疫センサーの開発

栗之丸隆章, 小島直, 吉岡恭子, 栗田僚二

日本化学会春季年会講演予稿集(CD-ROM), 97th ROMBUNNO.2A1‐42, Mar 3, 2017
核酸塩基を含むタンパク質の合成

加藤義雄, 小島直

第15回産総研・産技連LS-BT合同研究発表会要旨集,2016, 029, 2016
オリゴの合成後修飾に適したアミノリンカー固相担体の開発

小綿恵子, 小島直, 宮岸真, 小松康雄

アンチセンスシンポジウム講演要旨集, 23rd 61, Nov 20, 2013
Development of novel chemical reagents for reliable genetic analyses:- Process from an original idea to marketing of a chemical product used for life science -

KOMATSU Yasuo, KOJIMA Naoshi

Synthesiology English edition, 4(1) 1-8, 2011
遺伝子解析の精度向上と試薬の開発―ライフサイエンスに用いる化学試薬の製品化―

小松康雄, 小島直

Synthesiology, 3(3) 223-230, Aug, 2010
2本鎖構造の安定化を目的とした架橋化試薬の開発

市川康平, 小島直, 竹林知志恵, 平野悠, 小綿恵子, 小松康雄

アンチセンスシンポジウム講演要旨集, 20th 31, 2010
Development of novel chemical reagents for reliable genetic analyses

KOMATSU Yasuo, KOJIMA Naoshi

Synthesiology, 3(3) 223-230, 2010
DNA脱塩基部位に高効率で反応する試薬の開発

小島直, 竹林知志恵, 三上暁子, 大塚榮子, 小松康雄

日本環境変異原学会大会プログラム・要旨集, 38th 119, Nov 6, 2009
Development of a compound promoting interstrand crosslinking reaction at abasic sites of DNA

市川康平, 小島直, 竹林知志恵, 大塚榮子, 小松康雄

日本化学会講演予稿集, 89th(2) 1274, Mar 13, 2009
アルデヒド含有核酸を検出する試薬の開発

小松康雄, 小島直, 竹林知志恵, 三上暁子, 大塚榮子

日本薬学会年会要旨集, 129th(3) 76, Mar 5, 2009
P-038 Development of novel chemical probes to detect abasic sites in DNA(DNA damages,Poster Session)

Kojima Naoshi, Takebayashi Toshie, Mikami Akiko, Ohtsuka Eiko, Komatsu Yasuo

日本環境変異原学会大会プログラム・要旨集, (38) 119-119, 2009
Enhanced reactivity of amino-modified oligonucleotides by insertion of aromatic residue

Naoshi Kojima, Maiko Sugino, Akiko Mikami, Ken Nonaka, Yumi Fujinawa, Isamu Muto, Kenichi Matsubara, Eiko Ohtsuka, Yasuo Komatsu

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16(19) 5118-5121, Oct, 2006
Synthesis and properties of novel amino-modifying phosphoramidite reagents

小島直, 杉野麻衣子, 三上暁子, 佐藤浩輔, 大塚榮子, 小松康雄

日本化学会講演予稿集, 86th(2) 857, Mar 13, 2006
Generation of an abasic site in an oligonucleotide by using acid-labile 1-deaza-2 '-deoxyguanosine and its application to postsynthetic modification

N Kojima, M Sugino, A Mikami, E Ohtsuka, Y Komatsu

ORGANIC LETTERS, 7(4) 709-712, Feb, 2005
High throughput purification of amino-modified oligonucleotides and its application to novel detection system of gene expression

Nucleic Acids Sym. Ser., 49,181-182, 2005
Synthesis and application of new amino modification analogues for functional oligonucleotide

Nucleic Acids Sym. Ser., 48 21-22, 2004
A new, but old, nucleoside analog: the first synthesis of 1-deaza-2 '-deoxyguanosine and its properties as a nucleoside and as oligodeoxynucleotides

N Kojima, K Inoue, R Nakajima-Shibata, S Kawahara, E Ohtsuka

NUCLEIC ACIDS RESEARCH, 31(24) 7175-7188, Dec, 2003
New base pairing motifs. The synthesis and thermal stability of oligodeoxynucleotides containing imidazopyridopyrimidine nucleosides with the ability to form four hydrogen bonds

N Minakawa, N Kojima, S Hikishima, T Sasaki, A Kiyosue, N Atsumi, Y Ueno, A Matsuda

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 125(33) 9970-9982, Aug, 2003

Professional Memberships

Industrial Property Rights

特開2018-138012 核酸の液中固定化剤

栗田僚二, 小島直, 栗之丸隆章
WO2016-204107 核酸架橋体、二本鎖核酸に標的分子を結合させるための化合物及び二本鎖核酸に標的分子を結合させるための方法

小松康雄, 小島直
WO2016-199801 アミノ酸修飾核酸とその利用

加藤義雄, 小島直
特許第5808025号アミノ化オリゴヌクレオチド用固相担体

小松康雄, 小島直
特許第5196448号アミノオキシ基を含有する反応性化合物

小松康雄, 小島直, 野中謙
特許第4336820号オリゴヌクレオチドプローブ

小松康雄, 小島直, 佐藤浩輔, 野中謙, 藤縄由美
特開2006-075082 オリゴヌクレオチドの架橋反応

小松康雄, 小島直, 杉野麻衣子, 三上暁子, 野中謙, 上田洋二
特開2005-179280 デオキシヌクレオシド混合状態からのDNA合成試薬前駆体の製造

小島直, 佐野支帆子
特開2005-023050 新規核酸誘導体、及びそのフォスフォロアミダイト体、トリリン酸体の製造及び使用

小島直, 井上香織, 柴田梨奈