SAGA Yumiko

J-GLOBAL         Last updated: Apr 23, 2019 at 11:22
 
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Name
SAGA Yumiko
Section
Genetic Strains Research Center
Job title
Professor
Degree
Doctor of Science

Academic & Professional Experience

 
1984
   
 
: Memorial Sloan-kettering Cancer center
 
 
   
 
(New York, USA) post doctor
 
1989
   
 
: The Institute of physical
 
 
   
 
and chemical research center (RIKEN Tsukuba Research center).
 
 
   
 
A special research fellow of the basic sciences
 

Education

 
 
   
 
Doctoral Program in Biological Sciences, University of Tsukuba
 
 
   
 
University of Tsukuba
 

Published Papers

 
Niimi Y, Imai A, Nishimura H, Yui K, Kikuchi A, Koike H, Saga Y, Suzuki A
Developmental biology   445(1) 103-112   Jan 2019   [Refereed]
Fukuda K, Masuda A, Naka T, Suzuki A, Kato Y, Saga Y
PLoS genetics   14(6) e1007436   Jun 2018   [Refereed]
Zhao W, Oginuma M, Ajima R, Kiso M, Okubo A, Saga Y
eLife   7    May 2018   [Refereed]
Pui HP, Saga Y
Mechanisms of development   149 27-40   Feb 2018   [Refereed]
Zhou Z, Kawabe H, Suzuki A, Shinmyozu K, Saga Y
Nature communications   8 15662   Jun 2017   [Refereed]
Kabayama Y, Toh H, Katanaya A, Sakurai T, Chuma S, Kuramochi-Miyagawa S, Saga Y, Nakano T, Sasaki H
Nucleic acids research   45(9) 5387-5398   May 2017   [Refereed]
Pui HP, Saga Y
Mechanisms of development   144(Pt B) 125-139   Apr 2017   [Refereed]
Fujii M, Sakaguchi A, Kamata R, Nagao M, Kikuchi Y, Evans SM, Yoshizumi M, Shimono A, Saga Y, Kokubo H
Nature communications   8 14664   Mar 2017   [Refereed]
Wu Q, Fukuda K, Kato Y, Zhou Z, Deng CX, Saga Y
PLoS biology   14(9) e1002553   Sep 2016   [Refereed]

Misc

 
Trends Cardiovasc Med. 10 : 345-352, 2000   
MesP1 and MesP2 are essential for the development of cardiac mesoderm
Development. 127 : 3215-26, 2000   
MesP1 is expressed in the heart precursor cells and required for the formation of a single heart tube
Development. 126 : 3437-47, 1999   

Conference Activities & Talks

 
Essential role of the expression network between two RNA-binding proteins in the formation of sustainable primordial follicles
Yuzuru Kato,Yumiko Saga
28 Nov 2018   
Toward understanding the molecular mechanism of sexual fate decision in murine germ cells
SAGA Yumiko
5 Jun 2018   
Egg or sperm:how germ cell sex is determined
SAGA Yumiko
19 Oct 2018   
Mechanism of sexual differentiation of mouse ferm cells [Invited]
SAGA Yumiko
Developmental Biology   9 Oct 2018   
MOLECULAR DISSECTION OF NANOS-MEDIATED RNA-REGULATION [Invited]
SAGA Yumiko
CSH-Germ Cells Meeting   9 Oct 2018   
THE EXPRESSION NETWORK BETWEEN RNA-BINDING PROTEINS ELAV2 AND DDX6 IS REQUIRED FOR PRIMORDIAL FOLLICLE FORMATION
Yuzuru Kato,SAGA Yumiko
CSH-Germ Cells Meeting   9 Oct 2018   
DND1 protein is stabilized via interaction with its partner protein NANOS in mouse germ cells.
Danelle Wright,SAGA Yumiko
CSH-Germ Cells Meeting   9 Oct 2018   
Analysis of the gene expression changes during male germ cell differentiation with scRNA-Seq
Ryuki Shimada,SAGA Yumiko
CSH-Germ Cells Meeting   9 Oct 2018   
Requirement of DDX6 medicated P-body formation for the function of NANOS2 In male germ cell differentiation [Invited]
SAGA Yumiko
COMBIO2018 SYMPOSIUM PRESENTATIONS   23 Sep 2018   
Identification of Wnt5a downstream targets during early development in mouse
Rieko Ajima,Yumiko Saga
5 Jun 2018   
Structural association between mouse NANOS and DND1 RNA binding proteins
Danelle Wright,Yumiko Saga
5 Jun 2018   
To explore the feminizing genes mediated by SMAD4 in germ cell
Ryuki Shimada, Yumiko Saga
5 Jun 2018   
Analysis of granulosa cell progenitor differentiation during primordial follicle formation in mice.
Kurumi Fukuda,Yuzuru Kato,Yumiko Saga
5 Jun 2018   
Unique and cooperative limb specific enhancers regulate Fgf10 expression
Takenaka T, Andoh C, Shiraishi Y, Yamamoto S,Takemoto T, Hayashi S, Ajima R, Saga Y, Kuroiwa A
5 Jun 2018   
Mechanism of sexual differentiation of mouse germ cells. [Invited]
SAGA Yumiko
Life Science Seminar in ShanghaiTech University   26 Oct 2017   
Egg or sperm: how germ cell sex is determined. [Invited]
SAGA Yumiko
The International Research Symposium on Regulation of Germ Cell Development in vivo   26 Jul 2017   
Primordial follicles: insights from a study of RNA-binding proteins for its development and activation [Invited]
Yuzuru Kato,SAGA Yumiko
The International Research Symposium on Regulation of Germ cell Development in vivo and in vitro   26 Jul 2017   
Role of DDX6-mediated P-body formation in NANOS2 functio
Ryuki Shimada,SAGA Yumiko
The International Research Symposium on Regulation of Germ cell Development in vivo and in vitro   26 Jul 2017   
Role of Nanos Proteins in Male Germ Cell Development [Invited]
SAGA Yumiko
Gordon Research Conference(   18 Jun 2017   
Primordial follicle formation: insights from a study of an RNA-binding protein.
Yuzuru Kato,SAGA Yumiko
Gordon Research Conference   18 Jun 2017   
Role of DDX6-mediated P-body formation in male germ cell development. [Invited]
Ryuki Shimada,SAGA Yumiko
Gordon Research Conference   18 Jun 2017   
Post-transcriptional suppression of Dazl via its 3’UTR plays an important role in pre-implantation embryonic development. [Invited]
Kurumi Fukuda,SAGA Yumiko
Gordon Research Conference   18 Jun 2017   
Requirement of DDX6-mediated P-body formation in male germ cell development
Ryuki Shimada,SAGA Yumiko
9 May 2017   
Post-transcriptional suppression of Dazl via its 3’UTR plays an important role in pre-implantation embryonic development.
Kurumi Fukuda,SAGA Yumiko
9 May 2017   
Germ cell-specific conditional KO via Cas9-mediated chimera analyses. [Invited]
SAGA Yumiko
The 20th US-Japan Cellular and Gene Therapy Conference.   9 Mar 2017   
Egg or sperm: which is the default? [Invited]
SAGA Yumiko
The Allied Genetics Conference   13 Jul 2016   
Role of a 3’UTR-dependent DAZL suppression in mouse postnatal ovary.
Kurumi Fukuda,SAGA Yumiko
Mouse molecular genetics, The Allied Genetics Conference sponsored by the Genetics Society of America   13 Jul 2016   
Role of post transcriptional suppression of Dazl via its 3’UTR in female reproduction
SAGA Yumiko
日本発生生物学会Special Symposium   2 Jun 2016   
Sex determination of mouse germ cells. [Invited]
SAGA Yumiko
International Symposium on Epigenetic Dynamics and Regulation in Germ Cells.   17 Feb 2016   
Functional analyses of Nanos3 in mouse spermatogenesis. [Invited]
SAGA Yumiko
International Symposium on Epigenetic Dynamics and Regulation in Germ Cells.   17 Feb 2016   
Intrinsic regulation of the timing of gonocytes-to spermatogonia transition in the murine testes by an RNA-binding Protein NANOS2.
SAGA Yumiko
International Symposium on Epigenetic Dynamics and Regulation in Germ Cells.   17 Feb 2016   
An intrinsic buffering mechanism in spermatogonial stem cells controls the timing of mouse spermatogenesis. [Invited]
SAGA Yumiko
3 Dec 2015   
Germ cell-specific factors, NANOS2 and NANOS3 interact with distinct components of the CNOT complex [Invited]
SAGA Yumiko
3 Dec 2015   
Role of a 3’UTR-dependent suppression of Dazl in female reproduction.
SAGA Yumiko
3 Dec 2015   
Functional analyses of Nanos3 in mouse spermatogenesis.
SAKURI TAKAFUMI, SAGA Yumiko
3 Dec 2015   
Sex determination of mouse germ cells. [Invited]
SAGA Yumiko
Seminar in Francis Crick Institute.   15 Sep 2015   
Intrinsic regulation of the timing of gonocytes-to spermatogonia transition in the murine testes by an RNA-binding Protein NANOS2.
Pui Han Pin、SAGA Yumiko
Mouse Molecular Genetics   Sep 2015   
Functional analyses of Nanos3 in mouse spermatogenesis.
SAKURI TAKAFUMI, SAGA Yumiko
2 Jun 2015   
Mechanism of Sex determination of mouse germ cells [Invited]
SAGA Yumiko
Vertebrate Sex determination meeting   17 Apr 2015   
The mechanism of sex determination of mouse germ cells. [Invited]
SAGA Yumiko
Seventh international symposium on the biology of vertebrate sex determination.   13 Apr 2015   
Sex determination of mouse germ cells. [Invited]
SAGA Yumiko
Finnish-Japanese joint symposium   3 Mar 2015   
The role of FGF signaling in the initiation and maintenance of murine spermatogenesis
Pui, Han, Pin. SAGA Yumiko
25 Nov 2014   
Nanos2 antagonizes dazl to achieve sexual differentiation of male germ cells in mouse embryos
Yuzuru Kato, SAGA Yumiko,
CSH-GERM CELLS meeting   7 Oct 2014   
Female to male sex reversal of mouse PGCs independent of somatic environment.
Quan Wu,SAGA Yumiko
CSH-GERM CELLS meeting   7 Oct 2014   
Nanos2 organizes a post-transcriptional buffering system in mouse Spermatogonia Stem Cells
Zhou Zhi, SAGA Yumiko
7 Oct 2014   
Maintenance of spermatogonial stem cells (SSCs) via Nanos2-mediated mechanism. [Invited]
SAGA Yumiko
Stem cells seminar series, Cornell University   6 Oct 2014   
A revised model of gonocytes-to-spermatogonia transition in the mouse testis.
Pui Han Pin, SAGA Yumiko
27 May 2014   
Germ cell sexual differentiation requires Nanos2-mediated dosage control of Dazl in mice
Yuzuru Kato,SAGA Yumiko
27 May 2014   
Smad2 and p38 signaling orchestrate the male fate decision of mouse PGC.
Quan Wu, SAGA Yumiko
27 May 2014   
Suppression of pluripofency gene together with NANOS2 is essential for male sexual differentiation in mouse germ cells.
Hiroko Koike,SAGA Yumiko
27 May 2014   

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(特定領域研究)
Project Year: 2005 - 2009    Investigator(s): Yumiko SAGA
Somites provide bases of segmental structure such as vertebra and rimb of our body. Somites are generated periodically every 2 hours in mouse embryos. The periodicity is known to be regulated by so-called molecular clock which is regulated by an o...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(S))
Project Year: 2002 - 2006    Investigator(s): Yumiko SAGA
We tackled two major objectives concerning mouse organogenesis derived from mesodermal cells. One is heart morphogenesis and the other is somitogenesis.1.Heart morphogenesis1)We generated Mesp1, Mesp2 double-knockout ES cells and found that the ES...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(A))
Project Year: 1999 - 2001    Investigator(s): Yumiko SAGA
Elaborate metamerism in vertebrate somitogenesis is based on precise stripe pattern of gene expression, representing establishment of rostro-caudal polarity in the presomitic rnesoderm (PSM). Previously we have reported that expression pattern of ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1998 - 2000    Investigator(s): Yumiko SAGA
The somites are the first morphologically distinct segmental units which are formed in pairs on either side of the axial organs in a cranio-caudal order by the successive segmentation of the paraxial mesoderm. Segmented somites are known to be sub...
Generation and segmentation of mesodermal tissues