Katsuya Hirano

Profile Information

Affiliation: Faculty of Medicine, Kagawa University

Degree: M. D., Ph.D.(Jul, 1991, Kyushu University)

Researcher number: 80291516
ORCID ID: https://orcid.org/0000-0003-0164-1283
J-GLOBAL ID: 200901033023282325
Researcher ID: B-2785-2008
researchmap Member ID: 5000007391

External link: http://www.med.kagawa-u.ac.jp/~cardiovasc-physiol

My research intersts focus on physiology and pathophysiology of cardiovascular system in terms of intracellular signaling, especically calcium signaling and protein phosphorylation, thereby proposing novel strategies to combat cardiovascular diseases, which is collectively the main cause of death in Japan.

Research Interests

Research Areas

Research History

Apr, 2014

Professor, Department of Cardiovascular Physiology, Kagawa University, Faculty of Medicine
Aug, 2006 - Mar, 2014

Associate Professor, Department of Molecular Cardiology, Kyushu University, Graduate School of Medicine
Apr, 2000 - Jul, 2006

Assistant professor, Lecturer, Department of Molecular Cardiology, Kyushu University, Graduate School of Medicine
Apr, 1999 - Mar, 2000

Assistant professor, Lecturer, Department of Molecular Cardiology, Kyushu University, Graduate School of Medicine
Nov, 1996 - Mar, 1999

Assistant professor, Lecturer, Department of Molecular Cardiology, Kyushu University, Faculty of Medicine
Sep, 1993 - Nov, 1996

Assistant Research Scientist, Department of Physiology, Biochemistry, Animal Sciences; Muscle Biology Group, University of Arizona, Tucson, AZ, USA
Oct, 1990 - Aug, 1993

Research Associate, Department of Physiology, Biochemistry, Animal Sciences; Muscle Biology Group, University of Arizona, Tucson, AZ, USA
Jun, 1987 - Oct, 1990

Research fellow (thesis work), Department of Molecular Cardiology, Kyushu University, Graduate School of Medicine
Jun, 1985 - May, 1987

Resident, Department of Cardiovascular Medicine, Kyushu University Hosptical

Education

Jul, 1991

Kyushu University
Apr, 1979 - Mar, 1985

School of Medicine, Facultyof Medicine, Kyushu University

Committee Memberships

Jul, 2022 - Present

Awards committee, chairperson, Physiological Society of Japan
Mar, 2020 - Present

Vice President, Physiological Society of Japan
Nov, 2019 - Present

member of the committee for meetings, Physiological Society of Japan
Mar, 2018 - Present

理事, 日本生理学会
Mar, 2018 - Present

Member of the committee for Awards, Physiological Society of Japan
Aug, 2016 - Present

Board member, Japan Society of Smooth Muscle Research
Aug, 2016 - Present

Member of the committee for Academic Program, Japan Society of Smooth Muscle Research
Aug, 2016 - Present

Member of the committee for Publications, Japan Society of Smooth Muscle Research
Aug, 2016 - Present

Member of the committee for Future planning, Japan Society of Smooth Muscle Research
Apr, 2016 - Present

香川大学医師会, 香川大学医師会理事, 理事
Feb, 2015 - Present

Board member, Japanese Society of Circulation Research
Nov, 2014 - Present

Frontiers in Cardiovascular Medicine, Review editor, Review editor, Frontiers in Cardiovascular Medicine
Jun, 2014 - Present

Editorial adviser of Journal of Pharmacological Sciences, Japanese Pharmacological Society
2014 - Present

評議員, 日本病態生理学会
Oct, 2013 - Present

Fellow of American Heart Association (FAHA), American Heart Association (米国心臓協会)
Jul, 2013 - Present

Council member, International Society of Heart Research, Japan Section
Apr, 2013 - Present

評議員, 日本生理学会
2013 - Present

Council member, Japan Society of Smooth Muscle Research
Apr, 2012 - Present

Member of the committee for Publications and Public Relations, Physiological Society of Japan
Nov, 2010 - Present

Frontiers in Integrative and Regenerative Pharmacology, Review editor, Frontiers in Integrative and Regenerative Pharmacology

Awards

Papers

193

Critical role of Rho proteins in myosin light chain di-phosphorylation during early phase of endothelial barrier disruption

Mayumi Hirano, Katsuya Hirano

The Journal of Physiological Sciences, Dec, 2022
Lactulose Modulates the Structure of Gut Microbiota and Alleviates Colitis-Associated Tumorigenesis

Keizo Hiraishi, Feiyan Zhao, Lin Hai Kurahara, Xiaodong Li, Tetsuo Yamashita, Takeshi Hashimoto, Yoko Matsuda, Zhihong Sun, Heping Zhang, Katsuya Hirano

Nutrients, 14(3), Feb 1, 2022
Potential of the TRPM7 channel as a novel therapeutic target for pulmonary arterial hypertension.

Keizo Hiraishi, Lin Hai Kurahara, Kaori Ishikawa, Tetsuhiko Go, Naoya Yokota, Yaopeng Hu, Takayuki Fujita, Ryuji Inoue, Katsuya Hirano

Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 58 50-62, 2022
Increased lung uric acid deteriorates pulmonary arterial hypertension

Takanori Watanabe, Mariko Ishikawa, Kohtaro Abe, Tomohito Ishikawa, Satomi Imakiire, Kohei Masaki, Kazuya Hosokawa, Tomoko Fukuuchi, Kiyoko Kaneko, Toshio Ohtsubo, Mayumi Hirano, Katsuya Hirano, Hiroyuki Tsutsui

Journal of the American Heart Association, 10(23), Dec 7, 2021
Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension.

Keizo Hiraishi, Lin Hai Kurahara, Jianlin Feng, Aya Yamamura, Yuanyuan Cui, Eiji Yahiro, Hiroyasu Yokomise, Tetsuhiko Go, Kaori Ishikawa, Naoya Yokota, Atsushi Fujiwara, Miki Onitsuka, Kohtaro Abe, Shoji Ohga, Toru Satoh, Yasumasa Okada, Lixia Yue, Ryuji Inoue, Katsuya Hirano

Translational research : the journal of laboratory and clinical medicine, 233 127-143, Jul, 2021
Chronic Inhibition of Toll-Like Receptor 9 Ameliorates Pulmonary Hypertension in Rats.

Tomohito Ishikawa, Kohtaro Abe, Mariko Takana-Ishikawa, Keimei Yoshida, Takanori Watanabe, Satomi Imakiire, Kazuya Hosokawa, Mayumi Hirano, Katsuya Hirano, Hiroyuki Tsutsui

Journal of the American Heart Association, 10(7) e019247, Apr 6, 2021
Inhibitory Effects of Breast Milk-Derived Lactobacillus rhamnosus Probio-M9 on Colitis-Associated Carcinogenesis by Restoration of the Gut Microbiota in a Mouse Model

Haiyan Xu, Keizo Hiraishi, Lin-Hai Kurahara, Yuko Nakano-Narusawa, Xiaodong Li, Yaopeng Hu, Yoko Matsuda, Heping Zhang, Katsuya Hirano

NUTRIENTS, 13(4), Apr, 2021
Eicosapentaenoic acid ameliorates pulmonary hypertension via inhibition of tyrosine kinase Fyn.

Lin Hai Kurahara, Keizo Hiraishi, Aya Yamamura, Ying Zhang, Kohtaro Abe, Eiji Yahiro, Mikiko Aoki, Kaori Koga, Hiroyasu Yokomise, Tetsuhiko Go, Kaori Ishikawa, Zhang Bo, Hiroko Kishi, Sei Kobayashi, Narumi Aoki-Shoi, Satoh Toru, Ryuji Inoue, Katsuya Hirano

Journal of molecular and cellular cardiology, 148 50-62, Sep 2, 2020 Peer-reviewed
Pro-arrhythmic signaling of thyroid hormones and its relevance in subclinical hyperthyroidism

Tribulova N, Kurahara LH, Hlivak P, Hirano K, Bacova BS

Int J Mol Sci, 21(8) 2844, Apr, 2020 Peer-reviewed
Proteinase-activated receptor 1 antagonism ameliorates experimental pulmonary hypertension

Kuwabara Y, Tanaka M, Abe K, Hirano M, Hirooka Y, Tsutsui H, Sunagawa K, Hirano K

Cadiovasc Res, 115(8) 1357-1368, Jul, 2019 Peer-reviewedLast authorCorresponding author
血液凝固第XI因子の血管機能調節因子としての新たな機能の発見

劉文華, 橋本剛, 山下哲生, 平野勝也

日本生理学雑誌, 81(2) 35-35, May, 2019
Involvement of different receptor subtypes in prostaglandin E2-induced contractionand relaxation in the lower esophageal sphincter and esophageal body

Bai X, Ihara E, Otsuka Y, Tsuruta S, Hirano K, Tanaka Y, Ogino H, Hirano M, Chinen T, Akiho H, Nakamura K, Oda Y, Ogawa Y

Eur J Pharmacol, 857 172405, May, 2019 Peer-reviewed
COA-Cl prevented TGF-beta1-induced CTGF expression by Akt dephosphorylation in normal human dermal fibroblasts, and it attenuated skin fibrosis in mice models of systemic sclerosis

Nakai K, Karita S, Igarashi J, Tsukamoto I, Hirano K, Kubota Y

J Dermatol Sci, 94(1) 205-212, Apr, 2019 Peer-reviewed
Coagulation factor XI induces Ca2+ response and accelerates cell migration in vascular smooth muscle cells via proteinase-activated receptor 1

Liu W, Hashimoto T, Yamashita T, Hirano K

Am J Physiol Cell Physiol, 316(3) C377-C392, Mar, 2019 Peer-reviewed
血管平滑筋細胞において凝固第XI因子はトロンビン受容体PAR1を活性化し、細胞内Ca2+シグナルを発生させ、細胞遊走を促進する

平野勝也, 劉文華, 橋本剛, 山下哲生

血管, 42(1) 54-54, Jan, 2019
Proteinase-activated receptor 1 (PAR₁)-mediated cellular effects of coagulation factor XI in vascular smooth muscle cells

Hirano Katsuya, Liu Wenhua, Hiashimoto Takeshi, Yamashita Tetsuo

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 92 2-O-30, 2019
Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors

Tetsuo Yamashita, Daniel Ken Inaoka, Tomoo Shiba, Takumi Oohashi, So Iwata, Takao Yagi, Hiroaki Kosaka, Hideto Miyoshi, Shigeharu Harada, Kiyoshi Kita, Katsuya Hirano

Scientific Reports, 8(1) 2427, Dec 1, 2018 Peer-reviewed
新規競合阻害剤および混合型阻害剤との共結晶構造解析による酵母Type II NADH脱水素酵素Ndi1におけるユビキノン結合部位の同定

山下哲生, 稲岡健ダニエル, 志波智生, 大橋拓未, 岩田想, 矢木隆雄, 小坂博昭, 三芳秀人, 原田繁春, 北潔, 平野勝也

日本生化学会大会プログラム・講演要旨集, 91回 [1P-115], Sep, 2018
嫌気条件とNAD(P)HはApoptosis-inducing factorの大腸菌膜からの解離を抑制する

山下哲生, 松本感, 橋本剛, 五十嵐淳介, 小坂博昭, 平野勝也

日本生理学雑誌, 80(3) 36-36, Aug, 2018
血液凝固第XI因子が引き起こす血管平滑筋細胞のCa2+シグナルの発生メカニズムの解明

劉文華, 橋本剛, 山下哲生, 平野勝也

日本生理学雑誌, 80(3) 37-37, Aug, 2018

Misc.

210

N-terminal region of apoptosis-inducing factor facilitates dimer formation by stabilizing the charge transfer complex

Tetsuo Yamashita, Takeshi Hashimoto, Junsuke Igarashi, Hiroaki Kosaka, Katsuya Hirano

The Journal of Physiological Science, 70(Supplement 1) S137-S137, Mar, 2020 Peer-reviewed
血液凝固第XI因子の血管機能調節因子としての新たな機能の発見

劉文華, 橋本剛, 山下哲生, 平野勝也

日本生理学雑誌(Web), 81(2), 2019
血管平滑筋細胞において凝固第XI因子はトロンビン受容体PAR₁を活性化し,細胞内Ca²⁺シグナルを発生させ,細胞遊走を促進する

平野勝也, 劉文華, 橋本剛, 山下哲生

血管, 42(1), 2019
競合および混合阻害剤との共結晶構造解析により明らかとなった酵母由来Type II NADH脱水素酵素のユビキノン結合部位

山下哲生, 稲岡健ダニエル, 志波智生, 三芳秀人, 原田繁春, 北潔, 平野勝也

日本農芸化学会中四国支部講演会講演要旨集(Web), 51st, 2018
血液凝固第XI因子が引き起こす血管平滑筋細胞のCa²⁺シグナルの発生メカニズムの解明

劉文華, 橋本剛, 山下哲生, 平野勝也

日本生理学雑誌(Web), 80(3), 2018
嫌気条件とNAD(P)HはApoptosis-inducing factorの大腸菌膜からの解離を抑制する

山下哲生, 松本感, 橋本剛, 五十嵐淳介, 小坂博昭, 平野勝也

日本生理学雑誌(Web), 80(3), 2018
血液凝固第XI因子は電位作動性Ca²⁺チャネルを介して血管平滑筋細胞にCa²⁺シグナルを発生させる

平野勝也, 劉文華, 橋本剛, 山下哲生

血管, 41(1), 2018
ポドサイト障害進展におけるProteinase‐activated receptor‐1の関与

中野大介, GUAN Yu, 人見浩史, 平野勝也, 桑原孝成, 森潔, 向山政志, 西山成

日本腎臓学会誌, 59(6) 703-703, Sep 5, 2017
Proteinase‐activated receptor‐1はポドサイト障害によるアルブミン尿の病態に関与する

管有, 中野大介, 人見浩史, 平野勝也, 西山成

日本NO学会学術集会プログラム抄録集, 17th 57, May 1, 2017
Apoptosis-inducing factorと大腸菌膜との相互作用の解析

松本感, 山下哲生, 橋本剛, 五十嵐淳介, 小坂博昭, 平野勝也

日本生理学雑誌(Web), 79(1), 2017
凝固第XI因子が引き起こす血管平滑筋細胞のカルシウムシグナル伝達

平野勝也, 劉文華, 橋本剛, 山下哲生, 五十嵐淳介

血管, 40(1), 2017
凝固第XI因子の血管平滑筋作用

平野勝也, 劉文華, 橋本剛, 山下哲生

日本循環薬理学会口演要旨集, 27th, 2017
Contribution of proteinase-activated receptor 1 on the development of podocyte injury

NAKANO Daisuke, GUAN Yu, LIU Wenhua, ZHANG Yifan, LI Lei, HITOMI Hirofumi, HIRANO Katsuya, NISHIYAMA Akira

Annual Meeting of the Japanese Society of Toxicology, 44 O-53, 2017
Endogenous H2S maintains myogenic tone in lower esophageal sphincter: A possible target for treatment of lower esophageal sphincter dysfunction

Xiaopeng Bai, Eikichi Ihara, Yoshimasa Tanaka, Katsuya Hirano, Mayumi Hirano, Kazuhiko Nakamura

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 31 11-11, Nov, 2016
Trypsin Induced a Transient Contraction via a PAR2/TRPV1/Neurokinin Receptors Pathway in Circular Smooth Muscle of Porcine Esophageal Body

Xiaopeng Bai, Eikichi Ihara, Yoshimasa Tanaka, Katsuya Hirano, Mayumi Hirano, Hirotada Akiho, Kazuhiko Nakamura

GASTROENTEROLOGY, 150(4) S458-S458, Apr, 2016
Involvement of Different Subtypes of Receptor in Prostaglandin E2-Induced Motile Function in Lower Esophageal Sphincter and Esophageal Body Smooth Muscle

Xiaopeng Bai, Eikichi Ihara, Yoshimasa Tanaka, Katsuya Hirano, Mayumi Hirano, Kazuhiko Nakamura

GASTROENTEROLOGY, 150(4) S458-S458, Apr, 2016
新規アデノシン類似化合物COA-Cl(コアクロル)はcAMP/CREB/PGC-1αの経路を介して血管内皮成長因子(VEGF)の産生を促進する

岡本隆司, 五十嵐淳介, 橋本剛, 山下哲生, 苅田咲子, 窪田泰夫, 高田麻紀, 小西良士, 塚本郁子, 平野勝也

日本生理学雑誌(Web), 78(1), 2016
Activation of cAMP/CREB/PGC-1 alpha Pathway Plays a Key Role for a Novel Adenosine-like Angiogenic Agent COA-CI to Induce Production of Vascular Endothelial Growth Factor (VEGF) in Cultured Human Fibroblasts

Ryuji Okamoto, Junsuke Igarashi, Takeshi Hashimoto, Tetsuo Yamashita, Kazuyo Shoji, Yasuo Kubota, Norikazu Sakakibara, Ikuko Tsukamoto, Ryoji Konishi, Katsuya Hirano

CIRCULATION, 132, Nov, 2015
Proteinase-activated Receptor 1 Antagonist Inhibited the Progression of Monocrotaline Induced Pulmonary Hypertension in Rats

Yukimitsu Kuwabara, Kohtaro Abe, Mayumi Hirano, Yoshitaka Hirooka, Kenji Sunagawa, Katsuya Hirano

CIRCULATION, 132, Nov, 2015
A Key Role of PGC-1 alpha Co-transcription Factor, but not HIF1 alpha Transcription Factor, in Production of Vascular Endothelial Growth Factor (VEGF) by a Novel Angiogenic Agent COA-CI in Cultured Human Fibroblasts

Ryuji Okamoto, Junsuke Igarashi, Tetsuo Yamashita, Takeshi Hashimoto, Sakiko Karita, Kazuyo Shoji, Yasuo Kubota, Maki Takata, Fuminori Yamaguchi, Masaaki Tokuda, Norikazu Sakakibara, Ikuko Tsukamoto, Ryoji Konishi, Katsuya Hirano

CIRCULATION, 132, Nov, 2015

Books and Other Publications

The unique property of the pulmonary artery regarding the smooth muscle effects of proteinase-activated receptor 1: The possible contribution to the pathogenesis of pulmonary hypertension.

Springer, Tokyo, Japan, 2017
The unique property of the pulmonary artery regarding the smooth muscle effects of proteinase-activated receptor 1: The possible contribution to the pathogenesis of pulmonary hypertension.

Springer, Tokyo, Japan, 2017
Measurement of [Ca2+]i in smooth muscle strips using front-surface fluorimetry.

Humana Press, New York,, 2013 (ISBN: 9781627030854)
Measurement of [Ca2+]i in smooth muscle strips using front-surface fluorimetry.

Humana Press, New York,, 2013 (ISBN: 9781627030854)
Idendification of hydrogen peroxide as an endothelium-derived hyperpolarization factor in mice.

Taylor & Francis, London, UK, 2001
Cytosolic calcium transients in vascular smooth muscle.

in Ion Channels of Vascular Smooth Muscle Cells and Endothelial Cells, eds Sperelakis N and Kuriyama H., Elsivier, New York,, 1991
Effects of okadaic acid on cytosolic calcium concentration and contraction of porcine coronary artery.

in Advances in Second Messenger and Phosphoprotein Research vol.24, ed. Nishizuka Y., Raven Press, New York,, 1990
Effecs of okadaic acid on cytosolic calcium concentration and contraction of porcine coronary arter

Raven Press, New York, 1990

Presentations

120

Novel role of coagulation factor XI as a regulator of vascular smooth muscle function.

HIRANO Katsuya

The 9th Federation of the Asian and Oceanian Physiological Society Congress (FAOPS2019), Mar 29, 2019
Proteinase-activated receptor 1 (PAR1)-mediated cellular effects of coagulation factor XI in vascular smooth muscle cells

HIRANO Katsuya

Mar 16, 2019
血管平滑筋細胞において凝固第XI因子はトロンビン受容体PAR1を活性化し、細胞内Ca2+シグナルを発生させ、細胞遊走を促進する

平野勝也

第48回日本心脈管作動物質学会総会, Feb 8, 2019
トロンビンによる内皮バリアー機能障害の初期事象におけるRho-Rhoキナーゼの役割

平野勝也

第59回日本脈管学会総会, Oct 25, 2018
Novel function of coagulation factor XI as a regulator of vascular smooth muscle

Hirano K, Liu W, Hashimoto T, Yamashita T

The 7th Chiang Mai University-Kagawa University Joint Symposium 2018, Aug 29, 2018
凝固第XI因子の血管平滑筋作用

平野勝也

第３回日本肺高血圧・肺循環学会学術集会, Jun 22, 2018
血液凝固第XI因子は電位作動性Ca2+チャネルを介して血管平滑筋細胞にCa2+シグナルを発生させる

第47回日本心脈管作動物質学会年会, 2018
血液凝固第XI因子は電位作動性Ca2+チャネルを介して血管平滑筋細胞にCa2+シグナルを発生させる

第47回日本心脈管作動物質学会年会, 2018
Coagulaton factor XI induced Ca2+ response and cell migration in vascular smooth muscle cells

第95回日本生理学会大会, 2018
Novel strategy for treatment of pulmonary hypertension based on the unique property of pulmonary circulation regarding smooth muscle effect of proteinase-activated receptor 1

第95回日本生理学会大会, 2018
血管収縮の生理学‐平滑筋収縮装置のカルシウム感受性制御機構を中心に

第95回日本生理学会大会, 2018
Coagulaton factor XI induced Ca2+ response and cell migration in vascular smooth muscle cells

第95回日本生理学会大会, 2018
Novel strategy for treatment of pulmonary hypertension based on the unique property of pulmonary circulation regarding smooth muscle effect of proteinase-activated receptor 1

第95回日本生理学会大会, 2018
Physiology of vasoconstriction with a focus on the regulation of Ca2+ sensitivity of the contractile apparatus of smooth muscle

第95回日本生理学会大会, 2018
トロンビン受容体を標的とする新規肺高血圧治療の提案

第46回日本心脈管作動物質学会, 2017
A novel angiogenic agent COA-Cl promotes VEGF secretion from mouse C2C12 skeletal myocytes via the activation of cAMP/PKA/CREB/PGC-1alpha signaling axis

第94回日本生理学会大会, 2017
循環生理学教育における個人的悩み：医学生理学でどこまで教えると良いのか？

第94回日本生理学会大会シンポジウム「生理学から薬理学への医学教育キャリーオーバー：何をどこまで教えればよいのか？」, 2017
Involvement of Rho-Rho kinase pathway in peripheral actin filament formation, an initial event during thrombin-induced endothelial barrier disruption

第94回日本生理学会大会, 2017
Mifepristone, a steroid receptor antagonist, induces hepatic steatosis in association with upregulation of resistin expression in liver

第94回日本生理学会大会, 2017
Coagulation factor XIa induces Ca2+ influx via L-type Ca2+ channel in vascular smooth muscle cells

第94回日本生理学会大会, 2017

Teaching Experience

Professional Memberships

Works

日本平滑筋学会ロゴマークデザイン

Aug, 2014 - Present Other

Research Projects

血液凝固系の老化促進因子としての機能解明とその制御

科学研究費助成事業基盤研究(B), 日本学術振興会, Apr, 2022 - Mar, 2027

平野勝也
凝固系を標的とした高齢者のインスリン抵抗性改善策の開発

科学研究費助成事業挑戦的研究(萌芽), 日本学術振興会, Jul, 2020 - Mar, 2023

平野勝也
トロンビン受容体を標的とする新規肺高血圧治療法の開発

科学研究費補助金(基盤研究(C)), 日本学術振興会, Apr, 2016 - Mar, 2019

平野勝也
プロテイナーゼ活性化型受容体１を介する血管機能障害の分子機構解明

科学研究費補助金(基盤研究(C)), 日本学術振興会, Apr, 2015 - Mar, 2018

平野真弓
トロンビン受容体を標的とする核心的脳血管攣縮治療法の開発

科学研究費補助金挑戦的萌芽研究, 日本学術振興会, Apr, 2014 - Mar, 2016

平野勝也
トロンビン受容体の活性制御異常の分子機構解明と新たな動脈硬化治療戦略の開発

科学研究費補助金(基盤研究(C)), 日本学術振興会, Apr, 2012 - Mar, 2015

平野真弓
肺高血圧症におけるプロテイナーゼ活性化型受容体の役割解明と治療応用

科学研究費補助金(基盤研究(C)), 文部科学省, Apr, 2011 - Mar, 2013

平野勝也
Role of endothelial proteinase-activated receptors in the early phase of the development of vascular lesions.

Grants-in-Aid for Scientific Research(基盤研究(C)), Ministry of Education, Culture, Sports, Science and Technology, 2008 - 2010

Mayumi HIRANO, Katsuya HIRANO
Role of proteinase-activated receptors in the dysregulation of vascular tone and the enhancement of the proliferative state in vascular lesions

Grants-in-Aid for Scientific Research(基盤研究(C)), Ministry of Education, Culture, Sports, Science and Technology, 2005 - 2006

Katsuya HIRANO, 平野真弓
Elucidation of the Intracellular Signaling Networks Involved in the Proliferation and Functional Differentiation Induced by Cell-cell Contact in Vascular Endothelial Cells.

Grants-in-Aid for Scientific Research(基盤研究(C)), Ministry of Education, Culture, Sports, Science and Technology, 2004 - 2005

Mayumi HIRANO, 平野勝也
Elucidation of the mechanisms regulating the vascular tone and proliferation : Development of a novel technique to introduce protein into the intact cells and its applications

Grants-in-Aid for Scientific Research(基盤研究(C)), Ministry of Education, Culture, Sports, Science and Technology, 2003 - 2004

Katsuya HIRANO
内皮・平滑筋・繊維芽細胞の三次元共培養による血管構築を摸した血管モデルの作製

科学研究費補助金(萌芽研究), 文部科学省, 2002 - 2003

金出英夫, 平野勝也, 西村淳二
Elucidation of the Intracellular Signal Networks Involved in the Growth Arrest induced by Cell-cell Contact in Vascular Endothelial Cells

Grants-in-Aid for Scientific Research(基盤研究(C)), Ministry of Education, Culture, Sports, Science and Technology, 2002 - 2003

Mayumi HIRANO, 平野勝也
Molecular mechanisms of vasospasm : Intracellular signaling network underlying the Ca^<2+> of smooth muscle cells.

Grants-in-Aid for Scientific Research(基盤研究(B)), Ministry of Education, Culture, Sports, Science and Technology, 2001 - 2003

Hideo KANAIDE, 平野勝也, 西村淳二
p27^<Kip1>新規分子種の同定とがん抑制因子としての機能解明

科学研究費補助金(特定領域研究), 文部科学省, 2002 - 2002

平野勝也
The assessment of the contractility of the proliferating vascular smooth muscle

Grants-in-Aid for Scientific Research(基盤研究(C)), Ministry of Education, Culture, Sports, Science and Technology, 2001 - 2002

Junji NISHIMURA, 平野勝也
The assessment of the contractility of the proliferating airway smooth muscle.

Grants-in-Aid for Scientific Research(基盤研究(C)), Ministry of Education, Culture, Sports, Science and Technology, 2001 - 2002

Hidekazu SETOGUCHI, 平野勝也, 西村淳二
Development of a system for the continuous and simultaneous measurement of vascular intracellular signalings and metabolism

Grants-in-Aid for Scientific Research(基盤研究(B)), Ministry of Education, Culture, Sports, Science and Technology, 2001 - 2002

Hideo KANAIDE, 平野勝也, 西村淳二
Elucidation of the Mechanism for the cell cycle regulation by a novel isoform of p27^<Kip1> in the vascular cells

Grants-in-Aid for Scientific Research(基盤研究(C)), Ministry of Education, Culture, Sports, Science and Technology, 2001 - 2002

Katsuya HIRANO
p27^<kip1>新規分子種の同定とがん抑制因子としての機能解明

科学研究費補助金(特定領域研究(C)), 文部科学省, 2001 - 2001

平野勝也