KIMURA Hiroshi

J-GLOBAL         Last updated: Dec 16, 2019 at 09:18
 
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Name
KIMURA Hiroshi
URL
http://www.advmedpc-nms.com/english/
Affiliation
Nippon Medical School
Degree
Ph. D.(Chiba University)
Other affiliation
Nara Medical University

Research Areas

 
 

Academic & Professional Experience

 
 
   
 
Professor of Medicine, Nippon Medical School
 
Apr 2017
 - 
Today
Professor, Department of Advanced Medicine for Pulmonary Circulation and Respiratory Failure, Nippon Medical School Graduate School of Medicine
 
2001
 - 
2017
Professor, Nara Medical University
 
1997
 - 
2001
Associate Professor, Chiba Univ. School of
 
1992
 - 
1997
Assistant Professor, Chiba Univ. School of
 
1987
 - 
1992
Research Associate, Chiba Univ. School of
 
1988
 - 
1990
Postdoctoral fellow, University of Pennsylvania
 

Education

 
 
 - 
1978
School of Medicine, Kanazawa University
 

Committee Memberships

 
Apr 2014
 - 
Apr 2016
The Japanese Respiratory Society  Lead Managing Director
 
Apr 2014
 - 
Apr 2015
The Japanese Respiratory Socoety  President
 

Misc

 
Overall "gain" of the respiratory control system in normoxic humans awake and asleep
Honda Y, Hayashi F, Yoshida A, Ohyabu Y, Nishibayashi Y, Kimura H.
J. Appl. Physiol.   55 1530-1535   1983
Augmentation of CO2 drives by chlormadinone acetate, a synthetic progesterone.
Kimura H, Hayashi F, Yoshida A, Watanabe S, Hashizume I, Honda Y.
J. Appl. Physiol.   56 1627-1632   1984
Effects of chlormadinone acetate, a synthetic progesterone, on restoring impaired load compensation in chronic obstructive pulmonary disease.
Kimura H, Tatsumi K, Kuriyama T, Sugita T, Watanabe S, Nishibayashi Y, Honda Y.
Tohoku J. Exp. Med.   149 119-132   1986
Control of ventilation in extreme-altitude climbers.
Masuyama S, Kimura H, Sugita T, Kuriyama T, Tatsumi K, Kunitomo F, Okita S, Tojima H, Yuguchi Y, Watanabe S, Honda Y.
J. Appl. Physiol.   61 500-506   1986
Effects of chlormadinone acetate on ventilatory control in patients with chronic obstructive pulmonary disease.
Tatsumi K, Kimura H, Kunitomo F, Okita S, Tojima H, Yuguchi Y, Kuriyama T, Watanabe S, Honda Y.
Am. Rev. Respir. Dis.   133 552-557   1986
Sleep arterial oxygen desaturation and chemical control of breathing during wakefulness in COPD.
Tatsumi K, Kimura H, Kunitomo F, Kuriyama T, Watanabe S, Honda Y.
Chest.   90 68-73   1986
Difference in the effects of acetazolamide and ammonium cloride acidosis on ventilatory responses to CO2 and hypoxia in humans.
Tojima H, Kunitomo F, Okita S, Yuguchi Y, Tatsumi K, Kimura H, Kuriyama T, Watanabe S, Honda Y.
Jpn. J. Physiol.   36 511-521   1986
Differences in ventilatory responses to hypoxia and hypercapnia between normal and judo athletes with moderate obesity.
Nishibayashi Y, Kimura H, Maruyama R, Ohyabu Y, Masuyama H, Honda Y.
Eur. J. Appl. Physiol.   56 144-150   1987
Effects of chlormadinone acetate, a synthetic progesterone, on hypoxic ventilatory response in men.
Okita S, Kimura H, Kunitomo F, Tojima H, Yuguchi Y, Tatsumi K, Kuriyama T, Watanabe S, Honda Y.
Jpn. J. Physiol.   37 137-147   1987
Effects of chlormadinone acetate on sleep arterial oxygen desaturation in patients with chronic obstructive pulmonary disease.
Tatsumi K, Kimura H, Kunitomo F, Kuriyama T, Watanabe S, Honda Y.
Jpn. J. Physiol.   91 688-692   1987
Bilateral carotid body resection in man enhances hypoxic tachycardia.
Honda Y, Hashizume I, Kimura H, Severinghaus JW.
Jpn. J. Physiol.   38 917-928   1988
Influence of controlled breathing with diminished tidal volume on hypoxic heart rate response in man.
Kimura H, Nishibayashi Y, Hayashi F, Yoshida A, Honda Y.
Respiration.   54 103-109   1988
Obese patients with sleep apnea syndrome treated by progesterone.
Kimura H, Tatsumi K, Kunitomo F, Okita S, Tojima H, Kouchiyama S, Masuyama S, Shinozaki T, Mikami M, Watanabe S, Ishikawa I, Honda Y, Kuriyama T.
Tohoku J. Exp. Med.   156 151-157   1988
Sex differences in awake ventilatory drive and abnormal breathing during sleep in eucapnic obesity.
Kunitomo F, Kimura H, Tatsumi K, Kuriyama T, Watanabe S, Honda Y
Chest.   93 968-976   1988
Effects of acetazolamide in patients with sleep apnea syndrome.
Tojima H, Kunitomo F, Kimura H, Tatsumi K, Kuriyama T, Honda Y.
Thorax.   43 113-119   1988
Increased ventilatory response to acute hypoxia with high Hb-O2 affinity by Na-cyanate treatment in the rat.
Fukuda Y, Kobayashi T, Kimura H, Maruyama R.
Adv. Exp. Med. Biol.   222 331-339   1988
Progesterone therapy for sleep apnea syndrome evaluated by occlusion pressure responses to exogenous loading.
Kimura H, Tatsumi K, Kunitomo F, Okita S, Tojima H, Kouchiyama S, Masuyama S, Shinozaki T, Honda Y, Kuriyama T.
Am. Rev. Respir. Dis.   139 1198-1206   1989
Effect of a synthetic progestin on ventilatory response to hypoxia in anesthetized rats. 
Kimura H, Mikami M, Kuriyama T, Fukuda Y.
J. Appl. Physiol.   67 1754-1758   1989
Abnormal breathing during sleep and chemical control of breathing during wakefulness in patients with sleep apnea syndrome.
Kunitomo F, Kimura H, Tatsumi K, Okita S, Tojima H, Kuriyama T. Honda Y.
Am. Rev. Respir. Dis.   139 164-169   1989
Periodic breathing at high altitude and ventilatory responses to O2 and CO2. 
Masuyama S, Kouchiyama S, Shinozaki T, Okita S, Kunitomo F, Tojima H, Kimura H, Kuriyama T, Honda Y.
Jpn. J. Physiol.   39 523-535   1989
Respiration effect of synthetic progestin in small doses in normal men.
Mikami M, Tatsumi K, Kimura H, Honda Y, Kuriyama T.
 Chest.   96 1073-1075   1989
Arterial oxygen desaturation during sleep in interstitial pulmonary disease: correlation with chemical control of breathing during wakefulness. 
Tatsumi K, Kimura H, Kunitomo F, Kuriyama T, Honda Y.
Chest.   95 962-967   1989
holinergic stimulation of the pons depresses respiration in decerebrate cats.
Kimura H, Kubin L, Davies RO, Pack AI.
J. Appl. Physiol.   69 2280-2289   1990
Heart rate depression during sleep apnea depends on hypoxic chemosensitivity: a study at high altitude.
Masuyama S, Shinozaki T, Kouchiyama S, Okita S, Kimura H, Honda Y, Kuriyama T.
Am. Rev. Respir. Dis.   141 39-42   1990
The medullary projections of afferent bronchopulmonary C-fibers in the cat as shown by antidromic mapping.
Kubin L, Kimura H, Davies RO.
J. Physiol. - London   435 207-228   1991
Effect of sustained hypoxia on ventilatory and heart rate responses in carotid body-resected humans.
Tanaka M, Kimura H, Kunitomo F, Sakuma T, Kurono T, Hasako K, Uruma T, Kuriyama T. Honda Y.
Jpn. J. Appl. Physiol.   22 81-87   1992
Behavior of VRG neurons during the atonia of REM sleep induced by pontine carbachol in decerebrate cats.
Kubin L, Kimura H, Tojima H, Pack AI, Davies RO.
Brain Res.   592 91-100   1992
Spontaneous ventilation and respiratory motor output during carbachol-induced atonia of REM sleep in decerebrate cat. 
Tojima H, Kubin L, Kimura H, Davies RO.
Sleep.   15 404-414   1992
The effect of hypoxic depression on genioglossal muscle activity in healthy subjects and obstructive sleep apnea patients.
Kimura H, Niijima M, Edo H, Honda Y, Kuriyama T.
Sleep.   16 135-136   1993
Suppression of hypoglossal motoneurons during the carbachol-induced atonia of REM sleep is not caused by fast synaptic inhibition. 
Kubin L, Kimura H, Tojima H, Davies RO, Pack AI.
611 300-312   1993
Differences in the response of genioglossal muscle activity to sustained hypoxia between healthy subjects and patients with obstructive sleep apnea.
Kimura H, Niijima M, Edo H, Honda Y, Kuriyama T.
Respiration.   61 155-160   1994
Individual differences in ventilatory and HR responses to progressive hypoxia following 100 % O2 exposure in humans.
Honda Y, Masuda A, Kobayashi T, Tanaka M, Masuyama S, Kimura H, Kuriyama T. 
Adv. Exp. Med. Biol.   393 283-286   1995
Effect of prior O2 breathing on ventilatory response to sustained isocapnic hypoxia in adult humans.
Honda Y, Tani H, Masuda A, Kobayashi T, Nishino T, Kimura H, Masuyama S, Kuriyama T.
J. Appl. Physiol.   81 1627-1632   1996
Sleep oxygen desaturation in late sequelae of pulmonary tuberculosis. 
Sakuma T, Tatsumi K, Kimura H, Honda Y, Kuriyama T.
Intern. Med.   35 534-539   1996
Augmented ventilatory response to sustained normocapnic hypoxia following 100% O2 breathing in humans.
Honda Y, Tani H, Masuda A, Kobayashi T, Nishino T, Kimura H, Masuyama S, Kuriyama T.
Adv. Exp. Med. Biol.   410 371-375   1996
Analysis of heart rate profile during obstructive sleep apnea.
Okita S, Shinozaki T, Masuyama S, Kimura H, Honda Y, Kuriyama T.
Jpn. J. Appl. Physiol.   27 235-248   1997
Role of carotid body activity responsible for hypoxic ventilatory decline in awake humans. 
Honda Y, Kimura H, Tanaka M.
J. Appl. Physiol.   82 371-371   1997
Kimura H, Niijima M, Abe Y, Edo H, Sakabe H, Kojima A, Hasako K, Masuyama S, Tatsumi K, Kuriyama T: Compensatory excretion of prostacyclin and thromboxane metabolities in obstructive sleep apnea syndrome.
Intern. Med.   37, 127-133    1998
Kimura H, Kasahara Y, Kurosu K, Sugito K, Takiguchi Y, Terai M, Mikata A, Natsume M, Mukaida N, Matsushima K, Kuriyama T: Alleviation of monocrotaline-induced pulmonary hypertension by antibodies to a monocyte chemotactic and activating factor/monocyte・・・
Lab. Invest.   78, 571-581    1998
Kimura H, Kasahara Y, Kurosu K, Sugito K, Takiguchi Y, Terai M, Mikata A, Natsume M, Mukaida N, Matsushima K, Kuriyama T: Alleviation of monocrotaline-induced pulmonary hypertension by antibodies to a monocyte chemotactic and activating factor/mon...
Edo H, Kimura H, Niijima M, Sakabe H, Shibuya M, Kanamaru A, Homma I, Kuriyama T: Effects of chest wall vibration on breathlessness during hypercapnic ventilatory response.
J. Appl. Physiol.   84, 1487-1491    1998
Kimura H, Suda A, Sakuma T, Tatsumi K, Kawakami Y, Kuriyama T: Institutions participating in the Respiratory Failure Research Group in Japan. Nocturnal oxyhemoglobin desaturation and prognosis in COPD and late sequelae of pulmonary tuberculosis.
Intern. Med.   37, 354-359    1998
Role of EDRF in pulmonary circulation during sustained hypoxia.
Igari H, Tatsumi K, Sugito K, Kasahara Y, Saito M, Tani T, Kimura H, Kuriyama T.
J. Cardiovasc. Pharmacol.   31 299-305   1998
Control of upper airway function in response to hypoxia in patients with obstructive sleep apnea syndrome.
Niijima M, Kimura H, Edo H, Hasako K, Masuyama S, Tatsumi K, Honda Y, Kuriyama T.
Intern. Med.   37 134-140   1998
Role of carotid body in pressure response of pulmonary circulation in rats.
ugito K, Tatsumi K, Igari H, Kasahara Y, Tani T, Kimura H, Hayashi F, Kuriyama T.
Respir. Physiol.   111 283-293   1998
Arterial and mixed venous oxygen desaturation during incremental exercise in patients with chronic pulmonary disease.
Yamamoto T, Kimura H, Okada O, Katoh K, Tanabe N, Yasuda J, Yoshida Y, Kuriyama T.
Intern. Med.   37 280-285   1998
Fluorine-18- fluorodeoxyglucose and carbon-11-methionine evaluation of lymphadenopathy in sarcoidosis.
Yamada Y, Uchida Y, Tatsumi K, Yamaguchi T, Kimura H, Kitahara H, Kuriyama T.
J Nucl Med.   39 1160-1166   1998
A new aspect of the carotid body function controlling hypoxic ventilatory decline in humans.
Kimura H, Tanaka M, Nagao K, Niijima M, Masuyama S, Mizoo A, Uruma T, Tatsumi K, Kuriyama T, Masuda A, Kobayashi T, Honda Y.
Appl Human Sci.   17 131-137   1998
Deterioration of clinical course in patients with advanced primary lung cancer and atelectasis.
Takiguchi Y, Moriya T, Omori S, Suda A, Miyazawa H, Sugimoto T, Iioka Y, Yasuda J, Kimura H, Nagao K, Kuriyama T.
J. Bronchol.   5 293-297   1998
Possible presence of hypoxic ventilatory depression while breathing ambient air at sea level in humans.
Masuda A, Chowdhury MF, Tanaka M, Kobayashi T, Masuyama S, Kimura H, Kuriyama T, Honda Y.
Pathophysiology.   5 149-154   1998
Effect of prior O2 breathing on hypoxic hypercapnic ventilatory responses in humans.
Masuda A, Kobayashi T, Ohyabu Y, Nishino T, Masuyama S, Kimura H, Kuriyama T, Tani H, Komatsu T, Honda Y.
Adv Exp Med Biol.   450 1-6   1998
Nocturnal oxyhemoglobin desaturation and prognosis in COPD and late sequelae of pulmonary tuberculosis.
Intern. Med   37 354-359   1998
Hamada H, Terai M, Kimura H, Hirano K, Oana S, Niimi H: Increased expression of mast cell chymase in the lungs of congenital heart disease associated with early pulmonary vascular disease.
AM J Respir Crit Care Med   160, 1303-1308    1999
Niijima M, Kimura H, Edo H, Shinozaki T, Kang J, Masuyama S, Tatsumi K, Kuriyama T: Manifestation of pulmonary hypertension during REM sleep in obstructive sleep apnea syndrome.
AM J Respir Crit Care Med.   159, 1766-1772    1999
Moriya T, Takiguchi Y, Tabeta H, Watanabe R, Kimura H, Nagao K, Kuriyama T: Controlling malignant pericardial effusion by intrapericardial carboplatin administration in patients with primary non-small-cell lung cancer.
Brit. J. Cancer   83, 858-86    2000
Izumizaki M, Iwase M, Kimura H, Kuriyama T, Homma I: Central histamine contributed to the temperature-induced polypnea in mice.
J Appl Physiol   89, 770-776    2000
Izumizaki M, Iwase M, Kimura H, Yanai K, Watanabe T, Watanabe T, Homma I: Lack of temperature-induced polypnea in histamine H1 recepter-deficient mice.
Neurosci lett   284, 139-142    2000
Tokuda A, Itakura M, Onai N, Kimura H, Kuriyama T, Matsushima K: Pivotal role of CCR1+-positive leukocytes in bleomycin-induced lung fibrosis in mice.
J. Immunol   164, 2745-2751    2000
Uruma T, Kimura H, Kojima A, Hasako K, Masuyama S, Tatsumi K, Kuriyama T: Volume acceleration as an index of respiratory drive during exercise.
Clin. Sci.   98, 91-101    2000
Volume acceleration as an index of respiratory drive during exercise.
Uruma T, Kimura H, Kojima A, Hasako K, Masuyama S, Tatsumi K, Kuriyama T.
Clin. Sci.   98 91-101   2000
Pivotal role of CCR1+-positive leukocytes in bleomycin-induced lung fibrosis in mice.
Tokuda A, Itakura M, Onai N, Kimura H, Kuriyama T, Matsushima K.
J. Immunol.   164 2745-2751   2000
Cardiorespiratory changes in thoracoscopy under local anesthesia.
Cho K, Ozawa S, Kurihara M, Takeno Y, Kimura H, Kuriyama T.
J. Bronchol.   7 215-220   2000
Kimura H, Okada O, Tanabe N, Tanaka Y, Terai M, Takiguchi Y, Masuda M, Nakajima N, Hiroshima K, Inadera H, Matsushima K, Kuriyama T: Plasma monocyte chemoattractant protein-1 and pulmonary vascular resistance in chronic thromboembolic pulmonary hyperte・・・
Am J Respir Crit Care Med   164, 319-324    2001
Kimura H, Okada O, Tanabe N, Tanaka Y, Terai M, Takiguchi Y, Masuda M, Nakajima N, Hiroshima K, Inadera H, Matsushima K, Kuriyama T: Plasma monocyte chemoattractant protein-1 and pulmonary vascular resistance in chronic thromboembolic pulmonary hy...
Itakura M, Tokuda A, Kimura H, Nagai S, Yoneyama H, Onai N, Ishikawa S, Kuriyama T, Matsushima K: Blockade of secondary lymphoid tissue chemokine exacerbates Propionibacterium acnes-induced acute lung inflammation.
J Immunol   166, 2071-2079    2001
Kimura H. Okada O. Tanabe N. Tanaka Y. Terai M. Takiguchi Y. Masuda M. Nakajima N. Hiroshima K. Inadera H. Matsushima K. Kuriyama T. Plasma monocyte chemoattactant protein-1 and pulmonary vascular resistance in chronic thromboembolic pulmonary hyperten・・・
American Joournal of Respiratory & Critical Care Medicine   164(2) 319-24   2001
Kimura H. Okada O. Tanabe N. Tanaka Y. Terai M. Takiguchi Y. Masuda M. Nakajima N. Hiroshima K. Inadera H. Matsushima K. Kuriyama T. Plasma monocyte chemoattactant protein-1 and pulmonary vascular resistance in chronic thromboembolic pulmonary hyp...
Takiguchi Y, Uruma T, Hiroshima K, Motoori K, Watanabe R, Hamaoka T, Okada O, Kimura H, Kuriyama T: Stable pulmonary capillary haemangiomatosis without symptomatic pulmonary hypertension.
Thorax   56, 815-817    2001
Plasma MCP-1 and pulmonary vascular resistance in chronic thromboembolic pulmonary hypertension.
Kimura H, Okada O, Tanabe N, Tanaka Y, Terai M, Takiguchi Y, Masuda M, Nakajima N, Inadera H, Matsushima K, Kuriyama T.
Am J Respir Crit Care Med.   164 319-324   2001
Hontsu S. Konishi M. Takenaka H. Kasahara K. Takahashi K. Yoshimoto E. Murakawa K. Maeda K. Mikasa K. Kimura H. Sano R. Masutani T. Narita N. An elderly case with Listeria monocytogenes sepsis and pulmonary non-tuberculous mycobacterial infection. 'jap・・・
Kansenshogaku Zasshi - Journal of the Japanese Association for Infectious Diseases   76(12) 1025-9   2002
Hontsu S. Konishi M. Takenaka H. Kasahara K. Takahashi K. Yoshimoto E. Murakawa K. Maeda K. Mikasa K. Kimura H. Sano R. Masutani T. Narita N. An elderly case with Listeria monocytogenes sepsis and pulmonary non-tuberculous mycobacterial infection....
Takahashi K. Fukuoka K. Konishi M. Takenaka H. Sakamoto M. Okamoto Y. Yoshikawa M. Nishimoto Y. Kikkawa K. Imai T. Yoneda T. Narita N. Kimura H. A case of pulmonary arteriovenous malformation treated by transcatheter embolization using coils. 'Japanese'
Nihon Kokyuki Gakkai Zasshi   40(11) 900-4   2002
2002. Nov.
Fukuoka K, Arioka H, Iwamoto Y, Fukumoto H, Kurokawa H, Ishida T, Tomonari A, Suzuki T, Usuda J, Kanazawa F, Saijo N, Kimura H, and Nishio K: Mechanism of vinorelbine-induced. radiosensitization of human small cell lung cancer cells.
Cancer Chemother Pharmacol   49, 385-390    2002
Omori S. Takiguchi Y. Hiroshima K. Tanabe N. Tatsumi K. Kimura H. Nagao K. Kuriyama T. Peripheral pulmonary diseases : evaluation with endobronchial US initial experience.
Radiology   224(2) 603-8   2002
2002. Aug.
Watanabe A, Kawabata Y, Okada O, Tanabe N, Kimura H, Hatamochi A, Shinkai H, Sakai N, Shimada T, Hiroshima K, Kuriyama T: Ehlers-danlos syndrome type Ⅳ with few extrathoracic findings: a newly recognized point mutation in the COL3A1 gene.
Eur Respir J.   19, 195-198    2002
Hide W. Okabe S. Tatsumi K. Kimura H. Akasiba T. Chin K. Ohi M. Nakayama H. Satoh M. Kuriyama T. Nasal continuous positive airway pressuure improves quality of life in obesity hypoventilation syndrome. 'comment'
Sleep & Breathing   7(1) 3-12   2003
2003. Mar.
Sada A. Takiguchi Y. Omori S. Miyazawa H. Sugimoto T. Kurosu K. Tatsumi K. Tanabe N. Kuriyama T. Hiroshima K. Kimura H. Gene delivery to the lung by means of syngeneic fibroblasts: an experimental model.
Experimental Lung Research   29(4) 227-41   2003
2003. June
Izumizaki M. Tamaki M. Suzuki Y. Iwase M. Shirasawa T. Kimura H. Homma I. The affinity of hemoglobin for oxygen affects ventilatory responses in mutant mice with Prebyterian hemoglobinopathy.
American Journal of Physiology - Regulatory Integrative & Comparative Physiology   285(4) R747-53   2003
2003. October
Itoh T, Nagaya N, Fujii T, Iwase T, Nakanishi N, Hamada K, Kangawa K, Kimura H.A combination of oral sildenafil and beraprost ameliorates pulmonary hypertension in rats.
Am. J. Respir. Crit. Care Med.      2003
Endobronchial lesions involved in Mycobacterium avium infection.
Fukuoka K, Nakano Y, Nakajima A, Hontsu S, Kimura H.
Respir Med.   97 1261-1264   2003
Visualization of naturally occurring Foxp3+ regulatory T cells in normal and tumor-bearing mice.
Hontsu S, Yoneyama H, Ueha S, Terashima Y, Kitabatake M, Nakano A, Ito T, Kimura H, Matsushima K.
Int Immunopharmacol.   4 1785-1793   2004
Central histamine contributes to the inspiratory off-switch mechanism via H1 receptors in mice.
Miyamoto K, Iwase M, Kimura H, Homma I.
Respir Physiol Neurobiol.   144 25-33   2004
C-type natriuretic peptide attenuates bleomycin-induced pulmonary fibrosis in mice.
Murakami S, Nagaya N, Itoh T, Fujii T, Iwase T, Hamada K, Kimura H, Kangawa K
Am J Physiol Lung CellMol Physiol.   287 1172-1177   2004
C-type natriuretic peptide ameliorates monocrotaline-induced pulmonary hypertension in rats.
Itoh T, Nagaya N, Murakami S, Fujii T, Iwase T, Ishibashi-Ueda H, Yutani C, Yamagishi M, Kimura H, Kangawa K.
Am J Respir Crit Care Med.   170 1204-1211   2004
A potent antiangiogenic factor, endostatin prevents the development of asthma in a murine model.
Suzaki Y, Hamada K, Sho M, Ito T, Miyamoto K, Akashi S, Kashizuka H, Ikeda N, Nakajima Y, Iwase M, Homma I, Kobzik L, Kimura H.
J Allergy Clin Immunol.   116 1220-1227   2005
Adrenomedullin regenerates alveoli and vasculature in elastase-induced pulmonary emphysema in mice.
Murakami S, Nagaya N, Itoh T, Iwase T, Fujisato T, Nishioka K, Hamada K, Kangawa K, Kimura H.
Am J Respir Crit Care Med.   172 581-589   2005
Oxidative stress in obstructive sleep apnea.
Yamauchi M, Nakano H, Maekawa J, Okamoto Y, Ohnishi Y, Suzuki T, Kimura H.
Chest.   127 1674-1679   2005
Macrolide resistance of Streptococcus pneumoniae isolated during long-term macrolide therapy: difference between erythromycin and clarithromycin.
Kasahara K, Kita E, Maeda K, Uno K, Konishi M, Yoshimoto E, Murakawa K, Mikasa K, Kimura H.
J Infect Chemother.   11 112-114   2005
Tuberculous peritonitis developing during chemotherapy for pulmonary and intestinal tuberculosis: a case report.
Kasahara K, Fukuoka A, Murakawa K, Okamura H, Mikasa K, Narita N, Kimura H.
Respirology.   10 257-260   2005
Clonal dissemination of macrolide-resistant and penicillin-susceptible serotype 3 and penicillin-resistant Taiwan 19F-14 and 23F-15 Streptococcus pneumoniae isolates in Japan: a pilot surveillance study.
Kasahara K, Maeda K, Mikasa K, Uno K, Takahashi K, Konishi M, Yoshimoto E, Murakawa K, Kita E, Kimura H.
J Clin Microbiol.   43 1640-1645   2005
The peripheral blood Valpha24+ NKT cell numbers decrease in patients with haematopoietic malignancy.
Yoneda K, Morii T, Nieda M, Tsukaguchi N, Amano I, Tanaka H, Yagi H, Narita N, Kimura H.
Leuk Res   29 147-152   2005
Amphotericin B-induced nephrogenic diabets insipidus in a case of cryptococcemia.
Fujita Y, Kasahara K, Uno K, Konishi M, Maeda K, Yoshimoto E, Murakawa K, Mikasa K, Amano I, Morii T, Kimura H.
Intern Med.   44 458-461   2005
Subcutaneous Vaccination of Mycobacterium bovis Bacillus Calmette-Guerin Attenuates Allergic Inflammation in a Murine Model of Asthma. 
Ito T, Hamada K, Suzaki Y, Matsui N, Kita E, Kimura H.
Allergology International.   54 601-609   2005
Evidence for activation of nuclear factor kappaB in obstructive sleep apnea.
Yamauchi M, Tamaki S, Tomoda K, Yoshikawa M, Fukuoka A, Makinodan K, Koyama N, Suzuki T, Kimura H.
Sleep Breath.   10 189-193   2006
Physiological significance and therapeutic potential of adrenomedullin in pulmonary hypertension.
Murakami S, Kimura H, Kangawa K, Nagaya N.
Cardiovasc Hematol Disord Drug Targets.   6 125-132   2006
Histamine type 1 receptor deficiency reduces airway inflammation in a murine asthma model.
Miyamoto K, Iwase M, Nyui M, Arata S, Sakai Y, Gabazza EC, Kimura H, Homma I.
Int Arch Allergy Immunol.   140 215-222   2006
Increased plasma monocyte chemoattractant protein-1 level in idiopathic pulmonary arterial hypertension.
Itoh T, Nagaya N, Ishibashi-Ueda H, Kyotani S, Oya H, Sakamaki F, Kimura H, Nakanishi N.
Respirology.   11 158-163   2006
Prostacyclin agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice.
Murakami S, Nagaya N, Itoh T, Kataoka M, Iwase T, Horio T, Miyahara Y, Sakai Y, Kangawa K, Kimura H.
Am J Physiol Lung Cell Mol Physiol.   290 59-65   2006
Treatment with chondroitinase ABC alleviates bleomycin-induced pulmonary fibrosis.
Kai Y, Yoneyama H, Koyama J, Hamada K, Kimura H, Matsushima K.
Med Mol Morphol.   40 128-140   2007
Elevated circulating plasma adiponectin in underweight patients with COPD.
Tomoda K, Yoshikawa M, Itoh T, Tamaki S, Fukuoka A, Komeda K, Kimura H.
Chest.   132 135-140   2007
Adrenomedullin ameliorates lipopolysaccharide-induced acute lung injury in rats.
Itoh T, Obata H, Murakami S, Hamada K, Kangawa K, Kimura H, Nagaya N.
Am J Physiol Lung Cell Mol Physiol.   293 446-452   2007

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