上井幸司 (Uwai Koji) - マイポータル

基本情報

所属: 室蘭工業大学しくみ解明系領域化学生物工学ユニット准教授

学位: 博士（薬学）(2000年3月東北大学)

研究者番号: 80347905
J-GLOBAL ID: 200901004353084228
researchmap会員ID: 5000008905

外部リンク: https://u.muroran-it.ac.jp/lifeorg/

研究キーワード

研究分野

経歴

2011年4月 - 2011年4月

室蘭工業大学大学院工学研究科准教授
2006年4月 - 2011年3月

東北薬科大学講師
2002年4月 - 2006年3月

東北薬科大学助手
2000年9月 - 2002年3月

Max-Planck-Institute fur molekulare Physiologie博士研究員
2000年4月 - 2000年8月

金沢大学薬学部教務職員

学歴

委員歴

受賞

2021年12月

超異分野学会北海道フォーラム賞, 株式会社リバネス
2016年9月

Best Presentation Award, EPAM2016
2014年11月

Outstanding Poster Award in The 5th Forum on Studies of the Environmental and Public Health Issues in the Asian Mega-cities (EPAM 2014)
2013年9月

日本医療薬学会論文賞, 日本医療薬学会
2011年12月

第十五回生体触媒化学シンポジウムポスター賞, 第十五回生体触媒化学シンポジウム実行委員会

論文

124

Cross-Category Screening of Food Samples for Amyloid-β42 Aggregation-Inhibitory Activity Using a Microliter-Scale High-Throughput Screening System with Quantum-Dot-Labeled Aβ

Kota Nakamura, Manae Kawamura-Yamagishi, Masahiro Kuragano, Koji Uwai, Kiyotaka Tokuraku

Foods 15(12) 2108-2108 2026年6月11日
A high-throughput conditioned-media-based screening system identifies inhibitors of aggregation induced by iPSC-secreted amyloid β

Masahiro Kuragano, Naoki Nishishita, Koki Araya, Akira Kobayashi, Taro Q. P. Noguchi, Kenichi Watanabe, Shinya Watanabe, Stefan Baar, Koji Uwai, Kiyotaka Tokuraku

Nature Communications 2026年3月24日
Aggregation Characteristics of Tau Phosphorylated by Various Kinases as Observed by Quantum Dot Fluorescence Imaging.

Eisuke Ishibashi, Koki Araya, Kota Nakamura, Keiya Shimamori, Koji Uwai, Masahiro Kuragano, Kiyotaka Tokuraku

International journal of molecular sciences 26(20) 2025年10月17日
Microtubule-associated protein 4 forms aggregates consisting of helical filaments.

Shuto Miura, Eisuke Ishibashi, Takuto Nakamichi, Koji Uwai, Masahiro Kuragano, Kiyotaka Tokuraku

Biochemistry and biophysics reports 43 102118-102118 2025年9月
Using fluorescence spectra to quantitatively evaluate the constituent content and functionality of hydroponically grown Fragaria × Ananassa

Hidemichi Sano, Satoru Kawaguchi, Toshifumi Iimori, Masahiro Kuragano, Kiyotaka Tokuraku, Koji Uwai

European Food Research and Technology 2025年7月4日
Anti-Amyloid Aggregation Effects of Gobaishi (Galla chinensis) and Its Active Constituents.

Sharmin Akter, Takayuki Tohge, Sahithya Hulimane Ananda, Masahiro Kuragano, Kiyotaka Tokuraku, Koji Uwai

Molecules (Basel, Switzerland) 30(13) 2025年6月24日
On-Site Evaluation of Constituent Content and Functionality of Perilla frutescens var. crispa Using Fluorescence Spectra

Hidemichi Sano, Satoru Kawaguchi, Toshifumi Iimori, Masahiro Kuragano, Kiyotaka Tokuraku, Koji Uwai

Molecules 28(20) 7199-7199 2023年10月20日
Thiourea fused γ-amino alcohol organocatalysts for asymmetric Mannich reaction of β-keto active methylene compounds with imines.

Miku Nomura, Zubeda Begum, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano

RSC advances 13(6) 3715-3722 2023年1月24日
Cultivation Factors That Affect Amyloid-β Aggregation Inhibitory Activity in Perilla frutescens var. crispa

Keiya Shimamori, Tomohiko Nambu, Daiki Kawamata, Masahiro Kuragano, Naoki Nishishita, Toshifumi Iimori, Shinya Yamanaka, Koji Uwai, Kiyotaka Tokuraku

Foods 12 486 2023年1月20日査読有り
New boro amino amide organocatalysts for asymmetric cross aldol reaction of ketones with carbonyl compounds.

Zubeda Begum, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano

RSC advances 13(2) 888-894 2023年1月3日
Microwave-assisted synthesis and formation mechanism of fluorescent carbon dots from starch

Hisahiko Shibata, Mina Abe, Kazuya Sato, Koji Uwai, Kiyotaka Tokuraku, Toshifumi Iimori

Carbohydrate Polymer Technologies and Applications 3 100218 2022年6月査読有り
Chemical analysis of amyloid β aggregation inhibitors derived from Geranium thunbergii

Kenji Kubo, Hikaru Watanabe, Hiroyuki Kumeta, Tomoyasu Aizawa, Chigusa Seki, Hiroto Nakano, Kiyotaka Tokuraku, Koji Uwai

Bioorganic & Medicinal Chemistry 68 2022年5月査読有り
New small gamma-turn type N-primary amino terminal tripeptide organocatalyst for solvent-free asymmetric aldol reaction of various ketones with aldehydes

Rajkumar Thiyagarajan, Zubeda Begum, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano

RSC Advances 11(61) 38925-38932 2021年12月査読有り
Farm use of calcium hydroxide as an effective barrier against pathogens

Shinji Matsuzaki, Kento Azuma, Xuguang Lin, Masahiro Kuragano, Koji Uwai, Shinya Yamanaka, Kiyotaka Tokuraku

Scientific Reports 11(1) 2021年12月
Simple amino silyl ether organocatalyst for asymmetric hetero Diels–Alder reaction of isatins with enones

Perumalsamy Parasuraman, Divakar Ganesan, Zubeda Begum, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita …

CHIRALITY 33(8) 454-464 2021年8月査読有り
Simple primary β-amino alcohols as organocatalysts for the asymmetric Michael addition of β-keto esters to nitroalkenes

Zubeda Begum, Haruka Sannabe, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano

RSC Advances 11(1) 203-209 2020年12月査読有り
Daurichromenic Acid from the Chinese Traditional Medicinal Plant Rhododendron dauricum Inhibits Sphingomyelin Synthase and Aβ Aggregation

Hadya Virupaksha Deepak, Mahadeva M. Swamy, Yuta Murai, Yoshiko Suga, Masaki Anetai, Takuro Yo, Masahiro Kuragano, Koji Uwai, Kiyotaka Tokuraku, Kenji Monde

Molecules 25(18) 4077-4077 2020年9月査読有り
Evaluation of Amyloid β42 Aggregation Inhibitory Activity of Commercial Dressings by A Microliter-Scale High-Throughput Screening System Using Quantum-Dot Nanoprobes

Masahiro Kuragano, Wataru Yoshinari, Xuguang Lin, Keiya Shimamori, Koji Uwai, Kiyotaka Tokuraku

Foods 9(6) 825-825 2020年6月24日査読有り
Simple organocatalyst component system for asymmetric hetero Diels–Alder reaction of isatins with enones

Perumalsamy Parasuraman, Zubeda Begum, Madhu Chennapuram, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Suguru Tokiwa, Mitsuhiro Takeshita …

RSC Advances 10(10) 17486-17491 2020年4月査読有り
Design of calcium hydroxide–based granules for livestock sanitation

Shinya Yamanaka, Shuya Hirano, Koji Uwai, Kiyotaka Tokuraku

Case Studies in Chemical and Environmental Engineering 2020年4月査読有り