MISC

2004年8月

Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis speciosa

JOURNAL OF NATURAL PRODUCTS
  • Y Nakao
    • ,
  • WY Yoshida
    • ,
  • Y Takada
    • ,
  • J Kimura
    • ,
  • L Yang
    • ,
  • SL Mooberry
    • ,
  • PJ Scheuer
巻
67
号
8
開始ページ
1332
終了ページ
1340
記述言語
英語
掲載種別
DOI
10.1021/np049949f
出版者・発行元
AMER CHEMICAL SOC
A cytotoxic depsipeptide, kulokekahilide-2 (1), was isolated from a cephalaspidean mollusk, Philinopsis speciosa. The structure elucidation of kulokekahilide-2 was carried out by spectroscopic analysis and chemical degradation. Kulokekahilide-2 showed potent cytotoxicity against several cell lines (P388, SKOV-3, MDA-MB-435, and A-10 with IC50 values ranging from 4.2 to 59.1 nM) indicating cancer cell selectivity.
リンク情報
DOI
https://doi.org/10.1021/np049949f
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000223600200022&DestApp=WOS_CPL
ID情報
  • DOI : 10.1021/np049949f
  • ISSN : 0163-3864
  • Web of Science ID : WOS:000223600200022
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