Jul, 2004
Use of artificial dermis and recombinant basic fibroblast growth factor for creating a neovagina in a patient with Mayer-Rokitansky-Kuster-Hauser syndrome
HUMAN REPRODUCTION
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- Volume
- 19
- Number
- 7
- First page
- 1629
- Last page
- 1632
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1093/humrep/deh254
- Publisher
- OXFORD UNIV PRESS
Vaginal agenesis is an uncommon, but not rare, condition. Although there are many methods for creating a neovagina, the optimal treatment is unknown. An 18-year-old woman with Mayer-Rokitansky-Kuster-Hauser syndrome received vaginoplasty with a modified Wharton procedure using an artificial dermis (atelocollagen sponge). From 10 days after the operation, the patient was administered human recombinant basic fibroblast growth factor (bFGF) spray to accelerate epithelialization on the neovagina. At 50 days after the operation, we confirmed histological squamous epithelialization of the vaginal epithelium. At 12 months after the operation, the neovagina was at least 3.5 cm in width and similar to8 cm in length. In this case, use of artificial dermis and recombinant bFGF to create a neovagina was an easy, less invasive and useful method.
- Link information
- ID information
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- DOI : 10.1093/humrep/deh254
- ISSN : 0268-1161
- Web of Science ID : WOS:000222400100025