論文

査読有り 筆頭著者 最終著者
2020年1月

Long-term treatment with clarithromycin and carbocisteine improves lung function in chronic cough patients with chronic rhinosinusitis

American Journal of Otolaryngology
  • Shin Kariya
  • ,
  • Mitsuhiro Okano
  • ,
  • Takaya Higaki
  • ,
  • Seiichiro Makihara
  • ,
  • Tomoyasu Tachibana
  • ,
  • Kazunori Nishizaki

41
1
開始ページ
102315
終了ページ
102315
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.amjoto.2019.102315
出版者・発行元
Elsevier BV

Purpose: Chronic cough is a common complaint. Because the pathophysiology of chronic cough is complicated, the management of chronic cough is challenging. To the best of our knowledge, no previous study has examined the effect of macrolide antibiotics in chronic cough patients with chronic rhinosinusitis. The purpose of this study is to determine the changes in lung function for chronic cough patients with chronic rhinosinusitis who are treated by clarithromycin and carbocisteine.Materials and methods: Thirty-two chronic cough patients with chronic rhinosinusitis were recruited. Patients using inhaled corticosteroids and/or a bronchodilator, asthmatic patients, and patients with abnormal findings on auscultation and/or chest X-ray examination were excluded from this study. The patients received low-dose clarithromycin treatment for 3 months. Both before and after the treatment, a computed tomography (CT) scan of the paranasal sinuses, lung function test, peripheral blood test, and sino-nasal outcome test (SNOT-20) were applied.Results: Both the lung function and Lund-MacKay CT scores were improved by the long-duration therapy with macrolide antibiotics. The change in obstructive pulmonary function and the improvement of the CT score in each subject were significantly correlated. SNOT scores also improved after the treatment.Conclusions: The macrolide antibiotics treatment has beneficial effects on lung function in non-asthmatic chronic cough patients with normal chest X-ray findings. The improvement of chronic rhinosinusitis may have some role in the lung condition. Upper respiratory tract examination and treatment may be useful for the management of chronic cough.

リンク情報
DOI
https://doi.org/10.1016/j.amjoto.2019.102315
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000500833900011&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.amjoto.2019.102315
  • ISSN : 0196-0709
  • eISSN : 1532-818X
  • Web of Science ID : WOS:000500833900011

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