論文

査読有り
2016年5月

Effect of a low dose of midazolam on high blood pressure in dental patients: a randomised, double-blind, placebo-controlled, two-centre study

BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
  • Yoshihisa Watanabe
  • ,
  • Hitoshi Higuchi
  • ,
  • Minako Ishii-Maruhama
  • ,
  • Yuka Honda
  • ,
  • Akiko Yabuki-Kawase
  • ,
  • Ayaka Yamane-Hirano
  • ,
  • Yumiko Tomoyasu
  • ,
  • Shigeru Maeda
  • ,
  • Takuya Miyawaki

54
4
開始ページ
443
終了ページ
448
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.bjoms.2016.02.006
出版者・発行元
CHURCHILL LIVINGSTONE

Some patients have transient hypertension before dental treatment as a result of anxiety and stress. Midazolam is an anxiolytic, and thought to be effective for the management of this sort of transient hypertension. We have evaluated in a randomised, controlled trial whether a low dose of midazolam can lower blood pressure in dental patients to an acceptable level without excessive sedation. Suitable patients were randomised to be given midazolam (trial group) or physiological saline (control group) intravenously. Blood pressure, heart rate, degree of anxiety, and amount of sedation were measured before and after injection. After injection, blood pressure in the trial group significantly decreased to clinically acceptable levels compared with controls. The degree of anxiety in the trial group was also significantly less than that in the control group, but there were no significant differences in sedation. These results suggest that injection of a low dose of midazolam stabilises the blood pressure of dental patients with transient hypertension. (C) 2016 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

Web of Science ® 被引用回数 : 7

リンク情報
DOI
https://doi.org/10.1016/j.bjoms.2016.02.006
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27006286
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000375878400019&DestApp=WOS_CPL

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