論文

査読有り
2016年2月

Effect of carbamazepine or phenytoin therapy on blood level of intravenously administered midazolam: a prospective cohort study

JOURNAL OF ANESTHESIA
  • Tomoko Hayashi
  • ,
  • Hitoshi Higuchi
  • ,
  • Yumiko Tomoyasu
  • ,
  • Minako Ishii-Maruhama
  • ,
  • Shigeru Maeda
  • ,
  • Takuya Miyawaki

30
1
開始ページ
166
終了ページ
169
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00540-015-2063-3
出版者・発行元
SPRINGER JAPAN KK

Dental treatment of intellectually disabled patients is frequently performed under general anesthesia or sedation. Many of these patients have epilepsy and are medicated with antiepileptic drugs (AEDs). Carbamazepine (CBZ) and phenytoin (PHT) are known to promote the metabolism of midazolam, and the blood levels of midazolam in patients medicated with CBZ or PHT may be different from those in healthy individuals. In this study, we clarified the influences of CBZ and PHT on the blood level of intravenously administered midazolam in patients medicated with CBZ or PHT. The subjects were divided into the following groups: not medicated with AEDs (control group), medicated with only CBZ or PHT (mono CBZ/PHT group), and medicated with CBZ or PHT or both and other AEDs (poly CBZ/PHT group). General anesthesia was achieved using midazolam, propofol, and remifentanil, and then the blood midazolam level was measured at 10, 30, and 60 min after intravenous midazolam administration. According to the results, the blood midazolam level was significantly lower in the mono and poly CBZ/PHT groups than in the control group. This finding suggests that intravenously administered midazolam may have a weaker effect in patients medicated with CBZ or PHT.

Web of Science ® 被引用回数 : 2

リンク情報
DOI
https://doi.org/10.1007/s00540-015-2063-3
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26272251
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000369545600024&DestApp=WOS_CPL

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